iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046968

UUCD1 version

UUC-HoS-00015

Ensembl Protein ID

ENSP00000360407.2

UniProt Accession

O14965; E1P5F9; O60445; O75873; Q9BQD6; Q9UPG5; AURKA_HUMAN

Genbank Protein ID

BAA23592.1; AAC12708.1; AAC23448.1; AAC63902.1; AAF29508.1; AAF29508.1; AAF29508.1; AAF29508.1; AAF29508.1; AAF29508.1; CAC12717.1; EAW75550.1; EAW75551.1; EAW75552.1; EAW75553.1; EAW75554.1; EAW75555.1; EAW75556.1; EAW75557.1; EAW75558.1; EAW75559.1; EAW75561.1; EAW75562.1; AAH01280.1; AAH02499.1; AAH06423.1; AAH27464.1

Protein Name

Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

Genbank Nucleotide ID

D84212; AF008551; AF011467; AF011468; AF195947; AF195942; AF195943; AF195944; AF195945; AF195946; AL121914; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; BC001280; BC002499; BC006423; BC027464

Gene Name

AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000087586.17	ENST00000371356.6	ENSP00000360407.2
ENSG00000087586.17	ENST00000395907.5	ENSP00000379243.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC	PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	17060341

Organism

Homo sapiens

Functional Description
(View)

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Protein Sequence
(Fasta)

MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ 60
AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTAAACGCG ACTCAAGGCG TCGGGTTTGT TGTCAACCAA TCACAAGGCA GCCTCGCTCG 60
AGCGCAGGCC AATCGGCTTT CTAGCTAGAG GGTTTAACTC CTATTTAAAA AGAAGAACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0043203--C:axon hillock
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005829--C:cytosol
GO:0042585--C:germinal vesicle
GO:0072687--C:meiotic spindle
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0072686--C:mitotic spindle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0045120--C:pronucleus
GO:0005819--C:spindle
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0009948--P:anterior/posterior axis specification
GO:0051301--P:cell division
GO:0051642--P:centrosome localization
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0097421--P:liver regeneration
GO:0007100--P:mitotic centrosome separation
GO:0007067--P:mitotic nuclear division
GO:0007052--P:mitotic spindle organization
GO:0043066--P:negative regulation of apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0032091--P:negative regulation of protein binding
GO:1990138--P:neuron projection extension
GO:0045840--P:positive regulation of mitotic nuclear division
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046777--P:protein autophosphorylation
GO:0071539--P:protein localization to centrosome
GO:0006468--P:protein phosphorylation
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0046605--P:regulation of centrosome cycle
GO:0032465--P:regulation of cytokinesis
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0009611--P:response to wounding
GO:0007057--P:spindle assembly involved in female meiosis I
GO:0007051--P:spindle organization

KEGG

hsa:6790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000930	Aegilops tauschii	63.80	1.00e-103	369.00
IUUC-Aml-001426	Ailuropoda melanoleuca	92.25	0.00e+00	737.00
IUUC-Atr-002453	Amborella trichopoda	64.01	8.00e-108	383.00
IUUC-Apl-003626	Anas platyrhynchos	71.25	2.00e-154	538.00
IUUC-Aca-004602	Anolis carolinensis	66.50	2.00e-148	518.00
IUUC-Aly-005878	Arabidopsis lyrata	64.68	6.00e-105	373.00
IUUC-Ath-007117	Arabidopsis thaliana	65.43	2.00e-105	375.00
IUUC-Acl-008199	Aspergillus clavatus	50.62	6.00e-88	317.00
IUUC-Afl-008419	Aspergillus flavus	56.20	1.00e-86	313.00
IUUC-Afu-008751	Aspergillus fumigatus	50.30	2.00e-87	315.00
IUUC-Ani-009181	Aspergillus nidulans	46.05	2.00e-90	325.00
IUUC-Ang-009787	Aspergillus niger	49.55	5.00e-88	317.00
IUUC-Aor-009980	Aspergillus oryzae	56.20	1.00e-86	313.00
IUUC-Ate-010286	Aspergillus terreus	50.00	7.00e-87	314.00
IUUC-Ame-010849	Astyanax mexicanus	70.67	4.00e-128	451.00
IUUC-Bgr-012110	Blumeria graminis	59.15	3.00e-89	322.00
IUUC-Bta-013474	Bos taurus	88.83	0.00e+00	731.00
IUUC-Bci-013756	Botrytis cinerea	53.29	9.00e-95	340.00
IUUC-Bdi-014257	Brachypodium distachyon	63.60	6.00e-105	373.00
IUUC-Bol-016310	Brassica oleracea	61.25	1.00e-102	365.00
IUUC-Bra-017438	Brassica rapa	61.25	5.00e-104	370.00
IUUC-Cel-018157	Caenorhabditis elegans	61.23	5.00e-101	360.00
IUUC-Cja-019282	Callithrix jacchus	96.03	0.00e+00	771.00
IUUC-Cfa-020162	Canis familiaris	90.44	0.00e+00	727.00
IUUC-Cpo-021764	Cavia porcellus	84.28	0.00e+00	676.00
IUUC-Cre-022827	Chlamydomonas reinhardtii	66.92	3.00e-107	381.00
IUUC-Csa-023694	Chlorocebus sabaeus	97.02	0.00e+00	729.00
IUUC-Cho-024350	Choloepus hoffmanni	96.43	4.00e-113	400.00
IUUC-Cin-025542	Ciona intestinalis	70.33	4.00e-117	414.00
IUUC-Csv-025873	Ciona savignyi	69.96	3.00e-117	414.00
IUUC-Cgl-026632	Colletotrichum gloeosporioides	50.47	1.00e-83	303.00
IUUC-Cne-026928	Cryptococcus neoformans	61.09	2.00e-94	339.00
IUUC-Cme-027336	Cyanidioschyzon merolae	60.65	3.00e-119	421.00
IUUC-Dre-028198	Danio rerio	61.48	2.00e-131	462.00
IUUC-Dno-029928	Dasypus novemcinctus	87.86	0.00e+00	655.00
IUUC-Dor-030238	Dipodomys ordii	79.01	0.00e+00	641.00
IUUC-Dse-031266	Dothistroma septosporum	51.02	2.00e-92	332.00
IUUC-Dme-032007	Drosophila melanogaster	61.83	3.00e-100	358.00
IUUC-Ete-032911	Echinops telfairi	68.34	2.00e-134	471.00
IUUC-Eca-033749	Equus caballus	92.25	0.00e+00	729.00
IUUC-Eeu-035170	Erinaceus europaeus	87.90	0.00e+00	721.00
IUUC-Fca-035498	Felis catus	91.30	0.00e+00	727.00
IUUC-Fal-037397	Ficedula albicollis	67.63	1.00e-148	519.00
IUUC-Fox-037747	Fusarium oxysporum	51.03	6.00e-92	330.00
IUUC-Fso-038429	Fusarium solani	52.98	3.00e-91	328.00
IUUC-Gmo-039378	Gadus morhua	58.90	1.00e-124	439.00
IUUC-Ggr-039939	Gaeumannomyces graminis	58.28	1.00e-96	347.00
IUUC-Gga-040187	Gallus gallus	71.08	4.00e-152	531.00
IUUC-Gac-042223	Gasterosteus aculeatus	60.56	5.00e-131	461.00
IUUC-Gma-042870	Glycine max	62.94	4.00e-99	354.00
IUUC-Ggo-045617	Gorilla gorilla	99.26	0.00e+00	832.00
IUUC-Hvu-047072	Hordeum vulgare	53.09	1.00e-81	295.00
IUUC-Itr-048233	Ictidomys tridecemlineatus	78.66	4.00e-180	624.00
IUUC-Kpa-049093	Komagataella pastoris	55.94	2.00e-76	279.00
IUUC-Lch-050346	Latimeria chalumnae	68.01	1.00e-145	509.00
IUUC-Lpe-051466	Leersia perrieri	64.08	2.00e-105	374.00
IUUC-Lma-053006	Leptosphaeria maculans	56.07	2.00e-89	322.00
IUUC-Laf-053422	Loxodonta africana	86.39	0.00e+00	708.00
IUUC-Mcc-055245	Macaca mulatta	97.47	0.00e+00	723.00
IUUC-Mor-056952	Magnaporthe oryzae	56.83	1.00e-91	329.00
IUUC-Mpo-057605	Magnaporthe poae	57.19	3.00e-97	348.00
IUUC-Mtr-057726	Medicago truncatula	64.00	6.00e-105	373.00
IUUC-Mla-059174	Melampsora laricipopulina	62.93	5.00e-98	351.00
IUUC-Mga-059562	Meleagris gallopavo	58.55	2.00e-117	416.00
IUUC-Mvi-060305	Microbotryum violaceum	61.60	1.00e-93	337.00
IUUC-Mmr-061588	Microcebus murinus	90.55	0.00e+00	756.00
IUUC-Mdo-061914	Monodelphis domestica	78.35	2.00e-177	614.00
IUUC-Mmu-063288	Mus musculus	82.18	0.00e+00	654.00
IUUC-Mac-064969	Musa acuminata	63.67	4.00e-106	377.00
IUUC-Mpu-066855	Mustela putorius furo	91.21	0.00e+00	724.00
IUUC-Mlu-068046	Myotis lucifugus	90.18	0.00e+00	716.00
IUUC-Nfi-068527	Neosartorya fischeri	50.30	4.00e-88	318.00
IUUC-Ncr-068678	Neurospora crassa	58.16	6.00e-94	337.00
IUUC-Nle-069848	Nomascus leucogenys	98.01	0.00e+00	822.00
IUUC-Opr-070589	Ochotona princeps	82.13	0.00e+00	647.00
IUUC-Ont-071733	Oreochromis niloticus	61.22	6.00e-125	440.00
IUUC-Oan-073399	Ornithorhynchus anatinus	86.44	2.00e-153	534.00
IUUC-Ocu-074063	Oryctolagus cuniculus	87.38	0.00e+00	722.00
IUUC-Oba-075264	Oryza barthii	64.34	2.00e-105	375.00
IUUC-Obr-076048	Oryza brachyantha	63.64	1.00e-104	372.00
IUUC-Ogl-077637	Oryza glaberrima	66.42	5.00e-104	370.00
IUUC-Ogu-078830	Oryza glumaepatula	63.67	1.00e-105	375.00
IUUC-Oin-079150	Oryza indica	63.67	8.00e-106	376.00
IUUC-Olo-080398	Oryza longistaminata	57.68	2.00e-82	299.00
IUUC-Ome-081544	Oryza meridionalis	54.41	2.00e-90	325.00
IUUC-Oni-082250	Oryza nivara	63.67	8.00e-106	376.00
IUUC-Opu-083638	Oryza punctata	64.69	2.00e-106	378.00
IUUC-Oru-084981	Oryza rufipogon	63.67	5.00e-106	377.00
IUUC-Osa-085961	Oryza sativa	63.67	5.00e-106	377.00
IUUC-Olu-087880	Ostreococcus lucimarinus	69.96	4.00e-112	397.00
IUUC-Oga-088891	Otolemur garnettii	90.91	0.00e+00	726.00
IUUC-Oar-090021	Ovis aries	88.59	0.00e+00	708.00
IUUC-Ptr-091458	Pan troglodytes	99.75	0.00e+00	835.00
IUUC-Pan-092546	Papio anubis	97.02	0.00e+00	732.00
IUUC-Psi-093280	Pelodiscus sinensis	75.07	3.00e-161	561.00
IUUC-Pma-094298	Petromyzon marinus	76.60	7.00e-121	426.00
IUUC-Pno-094847	Phaeosphaeria nodorum	59.40	5.00e-89	321.00
IUUC-Ppa-095855	Physcomitrella patens	65.93	5.00e-108	384.00
IUUC-Pfo-096428	Poecilia formosa	61.08	8.00e-129	453.00
IUUC-Pab-098696	Pongo abelii	97.52	0.00e+00	802.00
IUUC-Pop-099405	Populus trichocarpa	61.59	4.00e-106	377.00
IUUC-Pca-100740	Procavia capensis	81.44	0.00e+00	672.00
IUUC-Ppe-101854	Prunus persica	63.19	1.00e-106	379.00
IUUC-Pva-103212	Pteropus vampyrus	89.15	0.00e+00	703.00
IUUC-Pgr-103474	Puccinia graminis	62.88	5.00e-98	351.00
IUUC-Ptt-103933	Puccinia triticina	49.03	2.00e-61	229.00
IUUC-Pte-104089	Pyrenophora teres	48.00	1.00e-90	327.00
IUUC-Pyt-104555	Pyrenophora triticirepentis	48.00	9.00e-91	327.00
IUUC-Rno-105057	Rattus norvegicus	83.42	0.00e+00	667.00
IUUC-Sha-107137	Sarcophilus harrisii	79.84	5.00e-180	623.00
IUUC-Sja-107767	Schizosaccharomyces japonicus	57.34	1.00e-98	353.00
IUUC-Spo-108078	Schizosaccharomyces pombe	61.09	3.00e-101	361.00
IUUC-Smo-109288	Selaginella moellendorffii	63.67	8.00e-108	383.00
IUUC-Sit-110246	Setaria italica	63.32	5.00e-106	377.00
IUUC-Sly-111379	Solanum lycopersicum	64.73	6.00e-106	377.00
IUUC-Stu-112777	Solanum tuberosum	61.25	3.00e-106	377.00
IUUC-Sbi-114325	Sorghum bicolor	64.52	3.00e-105	374.00
IUUC-Sre-115203	Sporisorium reilianum	58.65	1.00e-80	293.00
IUUC-Ssc-115361	Sus scrofa	88.83	0.00e+00	724.00
IUUC-Tgu-116967	Taeniopygia guttata	72.24	1.00e-147	515.00
IUUC-Tru-117570	Takifugu rubripes	62.32	1.00e-139	489.00
IUUC-Tsy-119280	Tarsius syrichta	70.22	2.00e-150	525.00
IUUC-Tni-120721	Tetraodon nigroviridis	62.44	7.00e-135	473.00
IUUC-Tca-121494	Theobroma cacao	61.67	2.00e-105	375.00
IUUC-Tre-121869	Trichoderma reesei	55.38	8.00e-96	343.00
IUUC-Tvi-122510	Trichoderma virens	56.90	7.00e-94	337.00
IUUC-Tae-123071	Triticum aestivum	63.80	1.00e-103	369.00
IUUC-Tur-126240	Triticum urartu	63.80	5.00e-103	367.00
IUUC-Tme-126921	Tuber melanosporum	60.29	6.00e-96	344.00
IUUC-Tbe-127872	Tupaia belangeri	84.73	0.00e+00	649.00
IUUC-Ttr-129134	Tursiops truncatus	89.41	0.00e+00	683.00
IUUC-Uma-129412	Ustilago maydis	59.25	2.00e-79	289.00
IUUC-Vda-130003	Verticillium dahliae	50.44	2.00e-94	338.00
IUUC-Vvi-131272	Vitis vinifera	63.64	3.00e-106	377.00
IUUC-Xtr-132019	Xenopus tropicalis	65.17	3.00e-148	518.00
IUUC-Xma-134203	Xiphophorus maculatus	61.31	2.00e-134	472.00
IUUC-Yli-134503	Yarrowia lipolytica	53.85	6.00e-86	310.00
IUUC-Zma-135232	Zea mays	61.82	4.00e-106	377.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence