iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004247

UUCD1 version

UUC-AnC-00388

Ensembl Protein ID

ENSACAP00000001822.2

UniProt Accession

H9G5Q5; H9G5Q5_ANOCA

Protein Name

Uncharacterized protein

Gene Name

KDM2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000001871.2	ENSACAT00000001866.2	ENSACAP00000001822.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	3.80e-07	30.2	985	1077
E3 activity/RING/PHD	3.40e-14	52.7	624	689

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 52   rrasrrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqela 137
           r +s  tpr  pr p + + pk+         p p +p p   p    d g  + ++ e+++ ++++l+++el+ + rvcr+w++ +
   Q: 985  RSSSTGTPRALPRPPPSLSPPKCMQMERHVIRPPPiSPPPDSLPL---DDGAAHVMQREVWMAVFRYLSHSELCVCMRVCRTWNRWC 1068
           778999***************987666666666551344444443...6677788889**************************555 PP
   S: 138  sqkalwktv 146
            +k+lw ++
   Q: 1069 CDKRLWTRI 1077
           559999876 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.......k...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++       k   +l+eC++C+e++Hp+Clk       v+eelpn+  w+CpkC+++
   Q: 624  AVCLVCGEAGKEDtaeeeggKfnlMLMECSICNEIIHPGCLKVResdgvVNEELPNC--WECPKCNHA 689
           79*********9977665552779*********************************..*******85 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

METGQDSGRR LRSISRRLYD ENEDLSDVEE IVSVRGFSLE EKLRSPGFRG QFVRAMEGKD 60
FTFEYVQREA LRAPLVFRSK AGLGIKMPDP DFTVRDVKLL VGSRRIVDVM DVNTQKGTEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGACAG GGCAAGATTC GGGAAGAAGA CTGGTGGGTA CTCCTTTATG ATTGTTTTTG 60
AACCTCCCCA AGAATTGAGG TTGGGTTTGG GTTCACACGT GCGACCCCTN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	77.71	0.00e+00	1808.00
IUUC-Apl-003787	Anas platyrhynchos	80.73	0.00e+00	1807.00
IUUC-Bta-013531	Bos taurus	78.23	0.00e+00	1849.00
IUUC-Cel-018303	Caenorhabditis elegans	44.55	3.00e-81	296.00
IUUC-Cja-018876	Callithrix jacchus	74.57	0.00e+00	1696.00
IUUC-Cfa-020857	Canis familiaris	78.02	0.00e+00	1838.00
IUUC-Cpo-021967	Cavia porcellus	77.35	0.00e+00	1754.00
IUUC-Cre-022608	Chlamydomonas reinhardtii	29.27	3.20e+00	28.10
IUUC-Csa-023210	Chlorocebus sabaeus	76.70	0.00e+00	1788.00
IUUC-Dre-028272	Danio rerio	62.44	0.00e+00	911.00
IUUC-Dno-030034	Dasypus novemcinctus	76.87	0.00e+00	1792.00
IUUC-Dor-030736	Dipodomys ordii	65.72	0.00e+00	688.00
IUUC-Eca-034255	Equus caballus	78.43	0.00e+00	1773.00
IUUC-Eeu-035038	Erinaceus europaeus	78.82	0.00e+00	936.00
IUUC-Fca-035786	Felis catus	78.00	0.00e+00	1783.00
IUUC-Fal-037589	Ficedula albicollis	78.95	0.00e+00	1886.00
IUUC-Gga-041103	Gallus gallus	82.52	0.00e+00	1049.00
IUUC-Gac-041304	Gasterosteus aculeatus	65.12	0.00e+00	907.00
IUUC-Ggo-044522	Gorilla gorilla	75.55	0.00e+00	1322.00
IUUC-Hsa-045877	Homo sapiens	78.32	0.00e+00	1814.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	76.40	0.00e+00	995.00
IUUC-Lch-049950	Latimeria chalumnae	73.27	0.00e+00	1721.00
IUUC-Loc-051972	Lepisosteus oculatus	67.09	0.00e+00	993.00
IUUC-Laf-053623	Loxodonta africana	76.33	0.00e+00	1781.00
IUUC-Mcc-054943	Macaca mulatta	77.33	0.00e+00	1807.00
IUUC-Meu-056259	Macropus eugenii	77.05	0.00e+00	1815.00
IUUC-Mga-059671	Meleagris gallopavo	80.88	0.00e+00	1850.00
IUUC-Mmr-061003	Microcebus murinus	78.12	0.00e+00	1821.00
IUUC-Mdo-062017	Monodelphis domestica	75.58	6.00e-177	613.00
IUUC-Mmu-063584	Mus musculus	76.59	0.00e+00	1793.00
IUUC-Mpu-066056	Mustela putorius furo	78.02	0.00e+00	1815.00
IUUC-Mlu-067850	Myotis lucifugus	77.93	0.00e+00	1819.00
IUUC-Nle-069837	Nomascus leucogenys	77.21	0.00e+00	1626.00
IUUC-Opr-070943	Ochotona princeps	75.56	0.00e+00	1706.00
IUUC-Ont-071663	Oreochromis niloticus	61.73	0.00e+00	1468.00
IUUC-Oan-072934	Ornithorhynchus anatinus	69.49	0.00e+00	1082.00
IUUC-Ocu-074706	Oryctolagus cuniculus	78.19	0.00e+00	1828.00
IUUC-Ola-086543	Oryzias latipes	59.65	0.00e+00	1431.00
IUUC-Oga-088671	Otolemur garnettii	73.82	0.00e+00	851.00
IUUC-Oar-089560	Ovis aries	73.72	0.00e+00	1766.00
IUUC-Ptr-090875	Pan troglodytes	78.40	0.00e+00	1833.00
IUUC-Pan-091788	Papio anubis	76.04	0.00e+00	1753.00
IUUC-Psi-093382	Pelodiscus sinensis	80.50	0.00e+00	1893.00
IUUC-Pma-094687	Petromyzon marinus	56.11	9.00e-93	334.00
IUUC-Ppa-095609	Physcomitrella patens	43.25	2.00e-58	218.00
IUUC-Pfo-096272	Poecilia formosa	63.22	0.00e+00	922.00
IUUC-Pab-097907	Pongo abelii	74.10	0.00e+00	1663.00
IUUC-Pca-100628	Procavia capensis	71.20	0.00e+00	1509.00
IUUC-Pva-102956	Pteropus vampyrus	69.27	0.00e+00	808.00
IUUC-Rno-105722	Rattus norvegicus	75.11	0.00e+00	1409.00
IUUC-Sce-106445	Saccharomyces cerevisiae	42.80	8.00e-49	187.00
IUUC-Sha-106626	Sarcophilus harrisii	71.69	0.00e+00	1605.00
IUUC-Spo-108120	Schizosaccharomyces pombe	32.26	3.00e-52	200.00
IUUC-Ssc-115918	Sus scrofa	75.40	0.00e+00	1355.00
IUUC-Tru-118638	Takifugu rubripes	64.32	0.00e+00	907.00
IUUC-Tbe-127654	Tupaia belangeri	66.27	0.00e+00	1372.00
IUUC-Ttr-128821	Tursiops truncatus	72.47	0.00e+00	1642.00
IUUC-Xtr-131823	Xenopus tropicalis	71.19	0.00e+00	1644.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence