iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029458.14	ENSMUST00000031414.14	ENSMUSP00000031414.8
ENSMUSG00000029458.14	ENSMUST00000140996.5	ENSMUSP00000122536.1
ENSMUSG00000029458.14	ENSMUST00000195952.4	ENSMUSP00000143350.1
ENSMUSG00000029458.14	ENSMUST00000142701.2	ENSMUSP00000143043.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-06	30.1	263	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle++++     l++ C+H fh +Clq+w           +CP+Cr
   Q: 263  CTVCLERMDESvngILTTLCNHSFHSQCLQRW--------DDTTCPVCR 303
           9*******77333366777*************........8889****8 PP

Organism

Mus musculus

Functional Description
(View)

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity).

Protein Sequence
(Fasta)

MSVSLVVIRL ELAGHSPVPT DFGFSAAAGE MSDEEIKKKT LASAVACLEG KSAGEKAAII 60
HQHLGRREMT DVIIETMKAR ADEVRDTVEE KKPSAAPVSA QRSREQSESV NTAPESPSKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTCAGAGA CGGCGGCCGA CAGGCGGAAG CGGAGGTTGT TGTGGCTCGG CAGGCTGCGC 60
GCGACGGGGG CTGCCGCTGC TGAGGCGGCG GCCGCGGCTT CTGAGGCGGT GGCGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011422--BRAP2
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50089--ZF_RING_2
PS50271--ZF_UBP

Pfam

PF07576--BRAP2
PF13639--zf-RING_2
PF02148--zf-UBP

SMART

SM00184--RING
SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0000151--C:ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0008139--F:nuclear localization sequence binding
GO:0003676--F:nucleic acid binding
GO:0000166--F:nucleotide binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000165--P:MAPK cascade
GO:0009968--P:negative regulation of signal transduction
GO:0007265--P:Ras protein signal transduction

KEGG

mmu:72399

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000519	Aegilops tauschii	30.58	2.00e-51	196.00
IUUC-Aml-002229	Ailuropoda melanoleuca	91.33	0.00e+00	1053.00
IUUC-Atr-002785	Amborella trichopoda	38.20	4.00e-89	322.00
IUUC-Apl-004048	Anas platyrhynchos	89.73	0.00e+00	900.00
IUUC-Aca-005133	Anolis carolinensis	84.83	0.00e+00	947.00
IUUC-Aly-006306	Arabidopsis lyrata	35.71	6.00e-78	285.00
IUUC-Ath-007604	Arabidopsis thaliana	35.47	5.00e-80	291.00
IUUC-Ago-007905	Ashbya gossypii	36.49	6.00e-71	261.00
IUUC-Acl-008310	Aspergillus clavatus	32.11	4.00e-66	246.00
IUUC-Afl-008497	Aspergillus flavus	31.39	2.00e-59	223.00
IUUC-Afu-008830	Aspergillus fumigatus	38.35	1.00e-63	238.00
IUUC-Ani-009485	Aspergillus nidulans	31.20	5.00e-67	248.00
IUUC-Ang-009603	Aspergillus niger	37.27	2.00e-64	240.00
IUUC-Aor-009935	Aspergillus oryzae	31.88	7.00e-63	234.00
IUUC-Ate-010485	Aspergillus terreus	30.77	1.00e-67	250.00
IUUC-Ame-011516	Astyanax mexicanus	85.65	0.00e+00	747.00
IUUC-Bgr-011985	Blumeria graminis	30.41	2.00e-44	174.00
IUUC-Bta-013203	Bos taurus	92.40	0.00e+00	1077.00
IUUC-Bci-013788	Botrytis cinerea	33.23	7.00e-53	202.00
IUUC-Bdi-014763	Brachypodium distachyon	35.83	3.00e-80	292.00
IUUC-Bol-015518	Brassica oleracea	33.40	5.00e-77	283.00
IUUC-Bra-017435	Brassica rapa	35.96	4.00e-77	282.00
IUUC-Cel-018194	Caenorhabditis elegans	36.90	2.00e-109	390.00
IUUC-Cja-018948	Callithrix jacchus	89.12	0.00e+00	1053.00
IUUC-Cfa-020377	Canis familiaris	91.22	0.00e+00	1092.00
IUUC-Cpo-021930	Cavia porcellus	92.40	0.00e+00	1067.00
IUUC-Cre-022571	Chlamydomonas reinhardtii	42.35	7.00e-58	217.00
IUUC-Csa-023554	Chlorocebus sabaeus	92.37	0.00e+00	922.00
IUUC-Cho-025045	Choloepus hoffmanni	87.55	8.00e-128	450.00
IUUC-Cin-025326	Ciona intestinalis	42.65	2.00e-111	395.00
IUUC-Csv-026232	Ciona savignyi	42.64	7.00e-112	397.00
IUUC-Cgl-026587	Colletotrichum gloeosporioides	30.10	6.00e-58	219.00
IUUC-Cne-026980	Cryptococcus neoformans	35.36	7.00e-50	192.00
IUUC-Cme-027262	Cyanidioschyzon merolae	35.20	1.00e-60	228.00
IUUC-Dre-028521	Danio rerio	76.56	0.00e+00	907.00
IUUC-Dno-029291	Dasypus novemcinctus	90.22	0.00e+00	1050.00
IUUC-Dor-030231	Dipodomys ordii	84.80	0.00e+00	982.00
IUUC-Dse-031234	Dothistroma septosporum	33.19	3.00e-55	210.00
IUUC-Dme-032095	Drosophila melanogaster	42.86	8.00e-119	420.00
IUUC-Ete-032227	Echinops telfairi	80.00	3.00e-177	615.00
IUUC-Eca-034404	Equus caballus	92.76	0.00e+00	1081.00
IUUC-Eeu-035030	Erinaceus europaeus	73.58	6.00e-125	441.00
IUUC-Fca-035428	Felis catus	92.21	0.00e+00	1072.00
IUUC-Fal-037435	Ficedula albicollis	88.63	0.00e+00	943.00
IUUC-Fox-037733	Fusarium oxysporum	33.02	1.00e-60	228.00
IUUC-Fso-038427	Fusarium solani	35.41	8.00e-60	225.00
IUUC-Gmo-038817	Gadus morhua	74.46	0.00e+00	851.00
IUUC-Ggr-039949	Gaeumannomyces graminis	28.54	3.00e-55	209.00
IUUC-Gga-040929	Gallus gallus	88.48	0.00e+00	956.00
IUUC-Gac-041893	Gasterosteus aculeatus	76.65	0.00e+00	870.00
IUUC-Gma-043119	Glycine max	35.92	1.00e-80	293.00
IUUC-Ggo-045106	Gorilla gorilla	92.94	0.00e+00	865.00
IUUC-Hsa-045685	Homo sapiens	90.88	0.00e+00	1089.00
IUUC-Hvu-047475	Hordeum vulgare	32.97	3.00e-34	138.00
IUUC-Itr-048406	Ictidomys tridecemlineatus	93.13	0.00e+00	1079.00
IUUC-Kpa-049175	Komagataella pastoris	37.72	4.00e-64	239.00
IUUC-Lch-050408	Latimeria chalumnae	80.43	0.00e+00	994.00
IUUC-Lpe-050777	Leersia perrieri	33.82	3.00e-65	243.00
IUUC-Loc-052160	Lepisosteus oculatus	65.92	0.00e+00	729.00
IUUC-Lma-053095	Leptosphaeria maculans	33.66	5.00e-76	279.00
IUUC-Laf-053497	Loxodonta africana	91.25	0.00e+00	1078.00
IUUC-Mcc-055381	Macaca mulatta	91.70	0.00e+00	1075.00
IUUC-Meu-056402	Macropus eugenii	67.95	0.00e+00	645.00
IUUC-Mor-057002	Magnaporthe oryzae	29.94	3.00e-60	226.00
IUUC-Mpo-057508	Magnaporthe poae	31.05	1.00e-53	204.00
IUUC-Mtr-058619	Medicago truncatula	40.12	2.00e-68	253.00
IUUC-Mla-058901	Melampsora laricipopulina	33.46	2.00e-70	260.00
IUUC-Mga-059667	Meleagris gallopavo	87.10	0.00e+00	890.00
IUUC-Mvi-060229	Microbotryum violaceum	29.48	7.00e-63	235.00
IUUC-Mmr-060881	Microcebus murinus	84.68	0.00e+00	948.00
IUUC-Mdo-062573	Monodelphis domestica	88.54	0.00e+00	989.00
IUUC-Mac-065512	Musa acuminata	37.61	3.00e-79	289.00
IUUC-Mpu-065816	Mustela putorius furo	92.09	0.00e+00	1077.00
IUUC-Mlu-067225	Myotis lucifugus	90.85	0.00e+00	1080.00
IUUC-Nfi-068534	Neosartorya fischeri	30.94	1.00e-64	241.00
IUUC-Ncr-068801	Neurospora crassa	28.14	1.00e-58	221.00
IUUC-Nle-069258	Nomascus leucogenys	91.17	0.00e+00	983.00
IUUC-Opr-070877	Ochotona princeps	78.73	0.00e+00	871.00
IUUC-Ont-072141	Oreochromis niloticus	76.76	0.00e+00	875.00
IUUC-Oan-072961	Ornithorhynchus anatinus	87.02	0.00e+00	999.00
IUUC-Ocu-074020	Oryctolagus cuniculus	92.36	0.00e+00	933.00
IUUC-Oba-075084	Oryza barthii	29.96	8.00e-66	244.00
IUUC-Obr-076840	Oryza brachyantha	35.52	2.00e-78	286.00
IUUC-Ogl-077880	Oryza glaberrima	44.98	2.00e-79	289.00
IUUC-Ogu-078968	Oryza glumaepatula	29.96	5.00e-66	245.00
IUUC-Oin-079200	Oryza indica	44.98	3.00e-79	289.00
IUUC-Olo-080753	Oryza longistaminata	33.24	3.00e-58	219.00
IUUC-Ome-081756	Oryza meridionalis	29.96	9.00e-66	244.00
IUUC-Oni-082434	Oryza nivara	30.74	9.00e-66	244.00
IUUC-Opu-083262	Oryza punctata	30.37	3.00e-65	243.00
IUUC-Oru-084381	Oryza rufipogon	29.96	5.00e-66	245.00
IUUC-Osa-085760	Oryza sativa	48.31	2.00e-71	262.00
IUUC-Ola-087390	Oryzias latipes	74.82	0.00e+00	827.00
IUUC-Olu-087694	Ostreococcus lucimarinus	32.54	1.00e-58	220.00
IUUC-Oga-088612	Otolemur garnettii	92.62	0.00e+00	1077.00
IUUC-Oar-089988	Ovis aries	92.04	0.00e+00	1064.00
IUUC-Ptr-090637	Pan troglodytes	91.05	0.00e+00	1092.00
IUUC-Pan-092506	Papio anubis	91.70	0.00e+00	1073.00
IUUC-Psi-093026	Pelodiscus sinensis	86.88	0.00e+00	928.00
IUUC-Pno-094779	Phaeosphaeria nodorum	31.49	3.00e-54	206.00
IUUC-Ppa-095731	Physcomitrella patens	38.37	9.00e-96	343.00
IUUC-Pfo-096725	Poecilia formosa	78.01	0.00e+00	866.00
IUUC-Pab-098413	Pongo abelii	92.27	0.00e+00	724.00
IUUC-Pop-099538	Populus trichocarpa	38.10	2.00e-80	293.00
IUUC-Pca-100130	Procavia capensis	78.91	0.00e+00	900.00
IUUC-Ppe-101843	Prunus persica	37.23	5.00e-85	308.00
IUUC-Pva-102752	Pteropus vampyrus	86.99	0.00e+00	1009.00
IUUC-Pgr-103478	Puccinia graminis	37.07	1.00e-75	277.00
IUUC-Ptt-103921	Puccinia triticina	36.90	6.00e-69	255.00
IUUC-Pte-104032	Pyrenophora teres	33.53	5.00e-73	269.00
IUUC-Pyt-104480	Pyrenophora triticirepentis	31.77	2.00e-71	263.00
IUUC-Rno-106037	Rattus norvegicus	82.37	0.00e+00	928.00
IUUC-Sce-106310	Saccharomyces cerevisiae	32.07	2.00e-58	220.00
IUUC-Sha-106752	Sarcophilus harrisii	86.25	0.00e+00	1010.00
IUUC-Sja-107665	Schizosaccharomyces japonicus	36.44	2.00e-81	296.00
IUUC-Spo-108042	Schizosaccharomyces pombe	34.27	1.00e-71	264.00
IUUC-Ssl-108504	Sclerotinia sclerotiorum	31.89	2.00e-52	200.00
IUUC-Smo-109399	Selaginella moellendorffii	38.28	2.00e-89	323.00
IUUC-Sit-110251	Setaria italica	38.26	7.00e-88	317.00
IUUC-Sly-111563	Solanum lycopersicum	44.14	9.00e-76	277.00
IUUC-Stu-112294	Solanum tuberosum	38.44	4.00e-79	288.00
IUUC-Sar-113080	Sorex araneus	78.03	4.00e-145	507.00
IUUC-Sbi-113915	Sorghum bicolor	36.91	1.00e-85	310.00
IUUC-Sre-114897	Sporisorium reilianum	36.21	3.00e-58	220.00
IUUC-Ssc-115369	Sus scrofa	98.91	4.00e-113	399.00
IUUC-Tgu-116710	Taeniopygia guttata	85.49	0.00e+00	986.00
IUUC-Tru-117941	Takifugu rubripes	76.20	0.00e+00	862.00
IUUC-Tsy-118902	Tarsius syrichta	79.33	2.00e-98	352.00
IUUC-Tni-120587	Tetraodon nigroviridis	75.97	0.00e+00	892.00
IUUC-Tca-121425	Theobroma cacao	38.24	5.00e-88	318.00
IUUC-Tre-121874	Trichoderma reesei	34.96	4.00e-58	219.00
IUUC-Tvi-122266	Trichoderma virens	35.82	4.00e-60	226.00
IUUC-Tae-123517	Triticum aestivum	35.70	2.00e-79	289.00
IUUC-Tur-126467	Triticum urartu	32.62	1.00e-51	197.00
IUUC-Tme-127096	Tuber melanosporum	35.17	1.00e-57	217.00
IUUC-Tbe-128012	Tupaia belangeri	85.95	0.00e+00	849.00
IUUC-Ttr-128388	Tursiops truncatus	92.58	0.00e+00	1081.00
IUUC-Uma-129610	Ustilago maydis	31.37	4.00e-56	213.00
IUUC-Vda-129830	Verticillium dahliae	28.98	1.00e-56	214.00
IUUC-Vpa-130171	Vicugna pacos	92.06	0.00e+00	1088.00
IUUC-Vvi-131063	Vitis vinifera	42.86	6.00e-82	298.00
IUUC-Xtr-132313	Xenopus tropicalis	80.74	0.00e+00	969.00
IUUC-Xma-133303	Xiphophorus maculatus	77.03	0.00e+00	862.00
IUUC-Yli-134669	Yarrowia lipolytica	32.00	6.00e-63	234.00
IUUC-Zma-135783	Zea mays	37.39	2.00e-82	299.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence