iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000071715.11	ENSMUST00000096357.11	ENSMUSP00000094084.5
ENSMUSG00000071715.11	ENSMUST00000133618.1	ENSMUSP00000121191.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-11	43.7	175	228
ULD/UDP/UFD/PB1	1.30e-19	71.3	237	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            ++l+d++++++ eL++k+Gdv++++   + +++Wl+g  + +g  G+fP  Fv+ l+
   Q: 175  AEALFDFTGNSKLELSFKAGDVIFLL--SKINKDWLEG--TSQGATGIFPGSFVKILK 228
           689***********************..8999******..89************9876 PP

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirs......faldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksll..r 78
           t+++++++++++        +++dl+++++f+dLl+++r+  e++++++al Y+D++GDlv+l sDed+  +v++++   s+k+l+  +
   Q: 237  TNWLRCYFYEDTGKtikdiaVEEDLSSTPLFKDLLALMRR--EFQREDIALSYQDAEGDLVRLLSDEDVGLMVKQARglpSQKRLFpwK 323
           589*********9999************************..********************************************999 PP
   S: 79   lliqkk 84
           l++++k
   Q: 324  LHVTQK 329
           *99985 PP

Organism

Mus musculus

Functional Description
(View)

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.

Protein Sequence
(Fasta)

MALAQQLRSE SDFEQLPDDV AVSANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR 60
QFYALQSKLE ERFGPESKNS PFTCSLPTLP AKVYMGAKQE IAETRIPALN AYMKNLLSLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCTCAAC TGCTGTGCAG CTGGGAAGTG GCTGAGAAGA CGTGTGAGGG CCAGGCAGCT 60
CAAAGCCTGA AGGAGGTACT TCAAGGAGGG TCCAGAGAAG CTGGGCAGGG CGGGACCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000919--NCF_P40
IPR000270--PB1_dom
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS51745--PB1
PS50195--PX
PS50002--SH3

Pfam

PF00564--PB1
PF00787--PX
PF00018--SH3_1

PRINTS

PR00497--P40PHOX
PR00452--SH3DOMAIN

SMART

SM00666--PB1
SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0005802--C:trans-Golgi network
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0016192--P:vesicle-mediated transport

KEGG

mmu:17972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001675	Ailuropoda melanoleuca	86.14	1.00e-174	605.00
IUUC-Apl-003431	Anas platyrhynchos	66.67	3.00e-135	474.00
IUUC-Aca-005176	Anolis carolinensis	70.83	6.00e-136	476.00
IUUC-Ame-011492	Astyanax mexicanus	58.59	5.00e-116	410.00
IUUC-Bta-013434	Bos taurus	87.02	9.00e-162	562.00
IUUC-Cja-019788	Callithrix jacchus	85.84	2.00e-174	604.00
IUUC-Cfa-021039	Canis familiaris	86.14	7.00e-169	586.00
IUUC-Cpo-021848	Cavia porcellus	85.25	8.00e-168	582.00
IUUC-Csa-023733	Chlorocebus sabaeus	85.71	7.00e-151	526.00
IUUC-Dre-027732	Danio rerio	53.09	8.00e-100	357.00
IUUC-Dno-029154	Dasypus novemcinctus	78.07	3.00e-152	530.00
IUUC-Eca-034062	Equus caballus	86.14	2.00e-168	584.00
IUUC-Eeu-035129	Erinaceus europaeus	72.48	1.00e-59	223.00
IUUC-Fca-036402	Felis catus	87.32	3.00e-177	614.00
IUUC-Fal-037105	Ficedula albicollis	68.14	1.00e-136	479.00
IUUC-Gmo-039144	Gadus morhua	53.75	5.00e-36	143.00
IUUC-Gga-040526	Gallus gallus	67.26	2.00e-134	472.00
IUUC-Ggo-044667	Gorilla gorilla	85.27	2.00e-130	458.00
IUUC-Hsa-045779	Homo sapiens	86.73	7.00e-177	612.00
IUUC-Itr-048385	Ictidomys tridecemlineatus	73.10	6.00e-135	473.00
IUUC-Lch-050264	Latimeria chalumnae	52.41	6.00e-113	400.00
IUUC-Loc-051887	Lepisosteus oculatus	55.08	1.00e-106	379.00
IUUC-Laf-054411	Loxodonta africana	79.52	9.00e-150	522.00
IUUC-Mcc-055835	Macaca mulatta	86.59	5.00e-171	593.00
IUUC-Meu-056875	Macropus eugenii	79.29	2.00e-92	331.00
IUUC-Mga-059737	Meleagris gallopavo	66.67	5.00e-134	470.00
IUUC-Mmr-061065	Microcebus murinus	83.68	2.00e-118	418.00
IUUC-Mdo-062598	Monodelphis domestica	78.82	1.00e-154	539.00
IUUC-Mpu-066142	Mustela putorius furo	87.91	4.00e-179	620.00
IUUC-Mlu-067898	Myotis lucifugus	87.78	4.00e-45	172.00
IUUC-Nle-069935	Nomascus leucogenys	74.19	8.00e-140	489.00
IUUC-Opr-070204	Ochotona princeps	83.46	1.00e-129	456.00
IUUC-Ont-072261	Oreochromis niloticus	54.29	4.00e-106	377.00
IUUC-Oan-072846	Ornithorhynchus anatinus	79.62	1.00e-73	268.00
IUUC-Ocu-074683	Oryctolagus cuniculus	87.65	3.00e-177	613.00
IUUC-Ogu-079036	Oryza glumaepatula	40.00	5.50e-01	26.60
IUUC-Ola-086700	Oryzias latipes	53.58	7.00e-97	347.00
IUUC-Oga-087992	Otolemur garnettii	87.09	4.00e-171	593.00
IUUC-Oar-089828	Ovis aries	86.22	2.00e-159	554.00
IUUC-Pan-092264	Papio anubis	86.73	8.00e-177	612.00
IUUC-Psi-093800	Pelodiscus sinensis	66.08	1.00e-129	456.00
IUUC-Pfo-096677	Poecilia formosa	51.12	2.00e-88	319.00
IUUC-Pab-097920	Pongo abelii	86.43	7.00e-177	612.00
IUUC-Pca-100312	Procavia capensis	69.23	7.00e-96	343.00
IUUC-Pva-102113	Pteropus vampyrus	84.94	1.00e-130	459.00
IUUC-Rno-105777	Rattus norvegicus	97.35	0.00e+00	684.00
IUUC-Sha-106666	Sarcophilus harrisii	78.53	1.00e-161	561.00
IUUC-Ssc-116056	Sus scrofa	86.43	3.00e-178	617.00
IUUC-Tgu-116797	Taeniopygia guttata	68.44	2.00e-138	485.00
IUUC-Tru-117860	Takifugu rubripes	53.89	1.00e-97	350.00
IUUC-Tsy-119537	Tarsius syrichta	84.24	5.00e-80	291.00
IUUC-Tni-119946	Tetraodon nigroviridis	55.68	1.00e-99	356.00
IUUC-Tbe-127274	Tupaia belangeri	75.00	1.00e-107	382.00
IUUC-Ttr-129026	Tursiops truncatus	87.08	3.00e-107	381.00
IUUC-Xtr-131910	Xenopus tropicalis	52.21	8.00e-107	380.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence