iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-104943

Ensembl Protein ID

ENSRNOP00000032429.3

UniProt Accession

Q6XVN8; MLP3A_RAT

Genbank Protein ID

AAP42560.1; AAH86389.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha

Genbank Nucleotide ID

AY206668; BC086389

Gene Name

Map1lc3a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000025443.4	ENSRNOT00000035060.4	ENSRNOP00000032429.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	1.70e-50	169.9	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeek 87
           +r++ev++ird++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++lvkiir+rlql++++a+fllvn+ s+vsvs+++a+iye+ek
   Q: 15   DRCKEVQQIRDQHPSKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQhSMVSVSTPIADIYEQEK 103
           69**************************99*********************************************************** PP
   S: 88   dedgflyvayaseetfG 104
           dedgfly++yas+etfG
   Q: 104  DEDGFLYMVYASQETFG 120
           ****************9 PP

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Protein Sequence
(Fasta)

MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGACCTGA CGTCACCCAG GCGAGTTACC TCCCGCAGCC GCCACCGCCG GGCTCAGCGC 60
GAGCCCCGCA GCCCTTGAGC TCGAGCCCCG GAGCCCCCGG CGCGCCGAAC CGCAGCCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005770--C:late endosome
GO:0005874--C:microtubule
GO:0031090--C:organelle membrane
GO:0008429--F:phosphatidylethanolamine binding
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0034198--P:cellular response to amino acid starvation
GO:0071280--P:cellular response to copper ion
GO:0070301--P:cellular response to hydrogen peroxide
GO:0000422--P:mitophagy
GO:0010040--P:response to iron(II) ion
GO:0010288--P:response to lead ion
GO:0043278--P:response to morphine
GO:0031667--P:response to nutrient levels

KEGG

rno:362245

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001444	Ailuropoda melanoleuca	98.18	1.00e-60	223.00
IUUC-Apl-003457	Anas platyrhynchos	87.50	3.00e-59	219.00
IUUC-Aca-004647	Anolis carolinensis	95.04	4.00e-66	242.00
IUUC-Ame-010918	Astyanax mexicanus	95.83	1.00e-65	241.00
IUUC-Bta-012939	Bos taurus	99.17	5.00e-68	248.00
IUUC-Cel-018533	Caenorhabditis elegans	59.65	2.00e-35	140.00
IUUC-Cja-018774	Callithrix jacchus	99.07	4.00e-60	222.00
IUUC-Cfa-020676	Canis familiaris	98.33	6.00e-67	246.00
IUUC-Cpo-022407	Cavia porcellus	100.00	2.00e-68	250.00
IUUC-Csa-023226	Chlorocebus sabaeus	100.00	2.00e-68	250.00
IUUC-Csv-026146	Ciona savignyi	50.00	6.00e-31	125.00
IUUC-Dre-027607	Danio rerio	95.83	1.00e-65	241.00
IUUC-Dno-029031	Dasypus novemcinctus	100.00	2.00e-68	250.00
IUUC-Ete-032915	Echinops telfairi	100.00	6.00e-60	221.00
IUUC-Eca-033844	Equus caballus	98.18	1.00e-60	223.00
IUUC-Eeu-034695	Erinaceus europaeus	99.07	2.00e-59	220.00
IUUC-Fca-035743	Felis catus	95.97	6.00e-66	242.00
IUUC-Fal-036789	Ficedula albicollis	96.30	1.00e-58	218.00
IUUC-Gmo-039473	Gadus morhua	95.00	2.00e-65	240.00
IUUC-Gga-040489	Gallus gallus	95.04	3.00e-66	242.00
IUUC-Gac-041849	Gasterosteus aculeatus	95.00	3.00e-65	239.00
IUUC-Ggo-044780	Gorilla gorilla	100.00	2.00e-60	223.00
IUUC-Hsa-046055	Homo sapiens	100.00	2.00e-68	250.00
IUUC-Itr-048837	Ictidomys tridecemlineatus	100.00	1.00e-68	250.00
IUUC-Lch-050578	Latimeria chalumnae	90.83	2.00e-62	230.00
IUUC-Loc-052008	Lepisosteus oculatus	96.67	3.00e-66	243.00
IUUC-Laf-054392	Loxodonta africana	91.67	3.00e-60	223.00
IUUC-Mcc-055894	Macaca mulatta	100.00	2.00e-60	223.00
IUUC-Mga-059593	Meleagris gallopavo	95.37	1.00e-58	217.00
IUUC-Mmr-061787	Microcebus murinus	100.00	2.00e-68	250.00
IUUC-Mdo-062276	Monodelphis domestica	97.52	3.00e-67	246.00
IUUC-Mmu-063357	Mus musculus	100.00	2.00e-68	250.00
IUUC-Mpu-065740	Mustela putorius furo	98.35	8.00e-68	249.00
IUUC-Mlu-067688	Myotis lucifugus	99.17	4.00e-68	249.00
IUUC-Nle-069441	Nomascus leucogenys	100.00	2.00e-60	223.00
IUUC-Opr-071159	Ochotona princeps	100.00	6.00e-60	221.00
IUUC-Ont-071272	Oreochromis niloticus	95.00	1.00e-65	240.00
IUUC-Oan-073060	Ornithorhynchus anatinus	88.46	4.00e-52	195.00
IUUC-Ola-087353	Oryzias latipes	93.33	2.00e-64	237.00
IUUC-Oga-088213	Otolemur garnettii	100.00	2.00e-68	250.00
IUUC-Oar-089438	Ovis aries	93.28	2.00e-61	226.00
IUUC-Ptr-090906	Pan troglodytes	100.00	2.00e-60	223.00
IUUC-Pan-091989	Papio anubis	100.00	1.00e-60	224.00
IUUC-Psi-093576	Pelodiscus sinensis	90.16	3.00e-59	219.00
IUUC-Pfo-097503	Poecilia formosa	95.00	2.00e-65	240.00
IUUC-Pab-098040	Pongo abelii	100.00	2.00e-68	250.00
IUUC-Ssc-115937	Sus scrofa	99.17	4.00e-67	245.00
IUUC-Tgu-116715	Taeniopygia guttata	95.41	3.00e-58	216.00
IUUC-Tru-117554	Takifugu rubripes	95.33	2.00e-57	213.00
IUUC-Tni-120190	Tetraodon nigroviridis	91.67	3.00e-63	233.00
IUUC-Vpa-130194	Vicugna pacos	97.20	9.00e-58	214.00
IUUC-Xtr-132257	Xenopus tropicalis	92.50	2.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence