iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	34.12	8.00e-146	516.00	IUUC-Hsa-046635

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Required for the biogenesis of eye pigment granules (PubMed:10549280). Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:9065698, PubMed:10549280). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599).

Protein Sequence
(Fasta)

MDTSMPNQPK FLPRIEHNSS GATANSYVAT ASGNPFETDD EDEIFSRHKM VLRVPSNCTG 60
DLMHLAVSRN WLVCLLGTPE RTTLLRFFLP RAIPPGEAVL EKYLSGSGYK ITRMFLDPTG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCCATCA CTTCTCAGAT TGGGGCGTTT TGGTAGAACT AATTGTAAAC AGCGGAGGAA 60
AAGGCAGCAG AATGGACACG TCTATGCCTA ACCAGCCCAA GTTCCTGCCC CGCATTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50236--CHCR

Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18

Gene Ontology

GO:0033263--C:CORVET complex
GO:0005768--C:endosome
GO:0030897--C:HOPS complex
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0045202--C:synapse
GO:0030674--F:protein binding, bridging
GO:0008270--F:zinc ion binding
GO:0097352--P:autophagosome maturation
GO:0007298--P:border follicle cell migration
GO:0051301--P:cell division
GO:0009267--P:cellular response to starvation
GO:0048072--P:compound eye pigmentation
GO:0008340--P:determination of adult lifespan
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0007032--P:endosome organization
GO:0008333--P:endosome to lysosome transport
GO:0006726--P:eye pigment biosynthetic process
GO:0008057--P:eye pigment granule organization
GO:0007041--P:lysosomal transport
GO:0007040--P:lysosome organization
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007220--P:Notch receptor processing
GO:0006727--P:ommochrome biosynthetic process
GO:0006622--P:protein targeting to lysosome
GO:0006728--P:pteridine biosynthetic process
GO:0035542--P:regulation of SNARE complex assembly
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

dme:Dmel_CG3093

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000419	Aegilops tauschii	26.60	2.00e-71	263.00
IUUC-Aml-001240	Ailuropoda melanoleuca	34.01	2.00e-146	512.00
IUUC-Atr-003125	Amborella trichopoda	27.04	2.00e-83	303.00
IUUC-Apl-004181	Anas platyrhynchos	33.33	4.00e-148	518.00
IUUC-Aca-004437	Anolis carolinensis	33.03	4.00e-142	498.00
IUUC-Aly-006046	Arabidopsis lyrata	28.56	2.00e-88	319.00
IUUC-Ath-006932	Arabidopsis thaliana	28.21	3.00e-88	318.00
IUUC-Ago-007800	Ashbya gossypii	21.87	1.00e-38	154.00
IUUC-Acl-008035	Aspergillus clavatus	27.69	3.00e-79	289.00
IUUC-Afl-008714	Aspergillus flavus	27.67	2.00e-77	283.00
IUUC-Afu-009063	Aspergillus fumigatus	27.86	3.00e-76	279.00
IUUC-Ani-009384	Aspergillus nidulans	27.37	3.00e-78	285.00
IUUC-Ang-009507	Aspergillus niger	27.93	2.00e-75	276.00
IUUC-Aor-010094	Aspergillus oryzae	27.67	6.00e-77	281.00
IUUC-Ate-010421	Aspergillus terreus	27.42	6.00e-69	254.00
IUUC-Ame-011797	Astyanax mexicanus	32.36	6.00e-148	517.00
IUUC-Bgr-012107	Blumeria graminis	27.24	6.00e-73	268.00
IUUC-Bta-012339	Bos taurus	34.49	4.00e-152	531.00
IUUC-Bci-013895	Botrytis cinerea	27.98	5.00e-86	311.00
IUUC-Bdi-014554	Brachypodium distachyon	27.87	3.00e-87	315.00
IUUC-Bol-015270	Brassica oleracea	28.76	8.00e-89	321.00
IUUC-Bra-017424	Brassica rapa	28.30	2.00e-84	306.00
IUUC-Cel-018455	Caenorhabditis elegans	27.59	6.00e-84	305.00
IUUC-Cja-019629	Callithrix jacchus	34.30	2.00e-147	516.00
IUUC-Cfa-020425	Canis familiaris	33.91	5.00e-145	508.00
IUUC-Cpo-021349	Cavia porcellus	33.94	7.00e-146	510.00
IUUC-Cre-022799	Chlamydomonas reinhardtii	27.41	5.00e-25	109.00
IUUC-Csa-023559	Chlorocebus sabaeus	33.91	1.00e-146	513.00
IUUC-Cho-024862	Choloepus hoffmanni	28.10	9.00e-57	214.00
IUUC-Cin-025599	Ciona intestinalis	30.12	2.00e-109	389.00
IUUC-Csv-026152	Ciona savignyi	30.26	7.00e-127	447.00
IUUC-Cgl-026551	Colletotrichum gloeosporioides	27.70	3.00e-78	285.00
IUUC-Cne-026907	Cryptococcus neoformans	26.91	5.00e-68	252.00
IUUC-Dre-027747	Danio rerio	33.13	2.00e-154	538.00
IUUC-Dno-029668	Dasypus novemcinctus	33.67	5.00e-145	507.00
IUUC-Dor-030404	Dipodomys ordii	35.27	1.00e-147	516.00
IUUC-Dse-031345	Dothistroma septosporum	28.05	6.00e-79	288.00
IUUC-Ete-032308	Echinops telfairi	39.10	5.00e-95	342.00
IUUC-Eca-033637	Equus caballus	33.91	1.00e-145	509.00
IUUC-Eeu-035151	Erinaceus europaeus	36.01	2.00e-126	446.00
IUUC-Fca-035585	Felis catus	33.91	3.00e-145	508.00
IUUC-Fal-037122	Ficedula albicollis	33.33	4.00e-146	511.00
IUUC-Fox-038030	Fusarium oxysporum	28.22	2.00e-78	286.00
IUUC-Fso-038426	Fusarium solani	27.58	3.00e-79	289.00
IUUC-Gmo-038784	Gadus morhua	33.06	1.00e-146	513.00
IUUC-Ggr-039973	Gaeumannomyces graminis	28.98	5.00e-67	248.00
IUUC-Gga-040692	Gallus gallus	33.37	2.00e-147	516.00
IUUC-Gac-041868	Gasterosteus aculeatus	33.83	2.00e-155	542.00
IUUC-Gma-044274	Glycine max	28.24	9.00e-93	334.00
IUUC-Ggo-045053	Gorilla gorilla	34.12	2.00e-146	512.00
IUUC-Hsa-046635	Homo sapiens	34.12	9.00e-147	513.00
IUUC-Hvu-047361	Hordeum vulgare	28.02	2.00e-87	316.00
IUUC-Itr-048868	Ictidomys tridecemlineatus	34.11	4.00e-146	511.00
IUUC-Kpa-049270	Komagataella pastoris	25.66	8.00e-55	207.00
IUUC-Lch-050188	Latimeria chalumnae	33.99	1.00e-139	489.00
IUUC-Lpe-051026	Leersia perrieri	29.04	2.00e-93	336.00
IUUC-Loc-051821	Lepisosteus oculatus	32.93	6.00e-150	524.00
IUUC-Lma-053178	Leptosphaeria maculans	29.91	2.00e-71	263.00
IUUC-Laf-053552	Loxodonta africana	33.91	2.00e-146	512.00
IUUC-Mcc-054667	Macaca mulatta	34.01	5.00e-146	511.00
IUUC-Meu-056422	Macropus eugenii	41.01	5.00e-91	328.00
IUUC-Mor-056981	Magnaporthe oryzae	28.18	1.00e-78	286.00
IUUC-Mtr-058703	Medicago truncatula	28.57	5.00e-91	328.00
IUUC-Mla-059088	Melampsora laricipopulina	31.01	2.00e-78	285.00
IUUC-Mga-059798	Meleagris gallopavo	33.57	5.00e-148	518.00
IUUC-Mvi-060404	Microbotryum violaceum	29.08	3.00e-95	343.00
IUUC-Mmr-061630	Microcebus murinus	34.49	3.00e-147	515.00
IUUC-Mdo-062354	Monodelphis domestica	33.84	4.00e-146	511.00
IUUC-Mmu-063199	Mus musculus	34.00	3.00e-148	518.00
IUUC-Mac-065595	Musa acuminata	29.29	4.00e-80	291.00
IUUC-Mpu-066596	Mustela putorius furo	34.01	1.00e-146	513.00
IUUC-Mlu-067455	Myotis lucifugus	34.05	1.00e-146	513.00
IUUC-Nfi-068565	Neosartorya fischeri	28.24	1.00e-78	286.00
IUUC-Ncr-068748	Neurospora crassa	27.43	9.00e-80	291.00
IUUC-Nle-068979	Nomascus leucogenys	33.99	5.00e-126	444.00
IUUC-Opr-070711	Ochotona princeps	33.70	1.00e-145	510.00
IUUC-Ont-072603	Oreochromis niloticus	33.57	1.00e-155	543.00
IUUC-Oan-073136	Ornithorhynchus anatinus	37.57	9.00e-88	316.00
IUUC-Ocu-074496	Oryctolagus cuniculus	34.22	4.00e-148	518.00
IUUC-Oba-075933	Oryza barthii	26.85	6.00e-75	275.00
IUUC-Obr-076290	Oryza brachyantha	29.04	5.00e-94	338.00
IUUC-Ogu-078728	Oryza glumaepatula	26.85	6.00e-75	275.00
IUUC-Oin-079954	Oryza indica	28.09	9.00e-82	297.00
IUUC-Olo-081033	Oryza longistaminata	26.43	3.00e-67	249.00
IUUC-Ome-081797	Oryza meridionalis	27.63	4.00e-81	295.00
IUUC-Oni-082802	Oryza nivara	26.85	6.00e-75	275.00
IUUC-Opu-083595	Oryza punctata	28.56	2.00e-90	326.00
IUUC-Oru-084199	Oryza rufipogon	26.85	6.00e-75	275.00
IUUC-Osa-085349	Oryza sativa	28.78	8.00e-91	327.00
IUUC-Ola-087482	Oryzias latipes	32.71	4.00e-149	521.00
IUUC-Olu-087797	Ostreococcus lucimarinus	24.24	5.00e-52	198.00
IUUC-Oga-088817	Otolemur garnettii	34.15	2.00e-147	515.00
IUUC-Oar-090350	Ovis aries	31.95	2.00e-97	349.00
IUUC-Ptr-090999	Pan troglodytes	34.32	8.00e-147	513.00
IUUC-Pan-092704	Papio anubis	34.01	5.00e-146	511.00
IUUC-Psi-093529	Pelodiscus sinensis	33.23	6.00e-148	517.00
IUUC-Pma-094400	Petromyzon marinus	32.99	9.00e-146	510.00
IUUC-Pno-094875	Phaeosphaeria nodorum	27.42	1.00e-81	297.00
IUUC-Ppa-095231	Physcomitrella patens	28.28	3.00e-92	332.00
IUUC-Pfo-096967	Poecilia formosa	33.13	9.00e-153	533.00
IUUC-Pab-098300	Pongo abelii	34.12	9.00e-147	513.00
IUUC-Pop-098966	Populus trichocarpa	28.30	5.00e-91	328.00
IUUC-Pca-100643	Procavia capensis	33.94	2.00e-133	469.00
IUUC-Ppe-101589	Prunus persica	28.61	1.00e-91	330.00
IUUC-Pva-102766	Pteropus vampyrus	33.37	3.00e-137	481.00
IUUC-Pgr-103330	Puccinia graminis	27.78	1.00e-79	291.00
IUUC-Ptt-103809	Puccinia triticina	30.38	3.00e-71	263.00
IUUC-Pte-104319	Pyrenophora teres	27.85	5.00e-80	291.00
IUUC-Pyt-104798	Pyrenophora triticirepentis	26.37	3.00e-67	249.00
IUUC-Rno-105817	Rattus norvegicus	34.45	2.00e-146	512.00
IUUC-Sce-106255	Saccharomyces cerevisiae	21.81	5.00e-33	135.00
IUUC-Sha-107479	Sarcophilus harrisii	34.28	9.00e-148	516.00
IUUC-Sja-107976	Schizosaccharomyces japonicus	23.14	4.00e-52	199.00
IUUC-Spo-108146	Schizosaccharomyces pombe	24.41	3.00e-47	183.00
IUUC-Ssl-108663	Sclerotinia sclerotiorum	27.91	1.00e-77	283.00
IUUC-Smo-109585	Selaginella moellendorffii	29.63	1.00e-85	310.00
IUUC-Sit-110275	Setaria italica	28.56	2.00e-90	326.00
IUUC-Sly-111073	Solanum lycopersicum	29.44	3.00e-93	336.00
IUUC-Stu-112392	Solanum tuberosum	28.97	5.00e-09	53.50
IUUC-Sar-113718	Sorex araneus	33.16	7.00e-137	481.00
IUUC-Sbi-114080	Sorghum bicolor	28.81	5.00e-96	345.00
IUUC-Sre-115160	Sporisorium reilianum	26.61	3.00e-79	290.00
IUUC-Ssc-115997	Sus scrofa	34.01	1.00e-145	509.00
IUUC-Tgu-116904	Taeniopygia guttata	33.67	2.00e-140	492.00
IUUC-Tru-117946	Takifugu rubripes	34.08	3.00e-154	538.00
IUUC-Tni-119692	Tetraodon nigroviridis	33.73	1.00e-151	530.00
IUUC-Tca-121455	Theobroma cacao	28.92	2.00e-94	340.00
IUUC-Tre-122128	Trichoderma reesei	28.45	7.00e-74	271.00
IUUC-Tvi-122657	Trichoderma virens	27.52	6.00e-76	278.00
IUUC-Tae-125953	Triticum aestivum	28.06	2.00e-87	317.00
IUUC-Tur-126110	Triticum urartu	25.41	1.00e-62	233.00
IUUC-Tme-127173	Tuber melanosporum	29.29	3.00e-56	212.00
IUUC-Ttr-128420	Tursiops truncatus	35.03	3.00e-154	538.00
IUUC-Uma-129580	Ustilago maydis	26.98	1.00e-80	294.00
IUUC-Vda-129790	Verticillium dahliae	27.15	2.00e-73	270.00
IUUC-Vvi-131095	Vitis vinifera	27.66	3.00e-87	316.00
IUUC-Xtr-131906	Xenopus tropicalis	33.37	5.00e-150	524.00
IUUC-Xma-134197	Xiphophorus maculatus	32.67	9.00e-152	530.00
IUUC-Yli-134617	Yarrowia lipolytica	23.98	8.00e-54	204.00
IUUC-Zma-134979	Zea mays	26.84	2.00e-78	286.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence