iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-38	131.3	680	733

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++y+y +qn+deL+l++Gd v+v+  ++ d gW +gv+  ++k G fP n+v+ +
   Q: 680  RAMYQYRPQNEDELELREGDRVDVM--QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 733
           699*********************9..88999*********************875 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity).

Protein Sequence
(Fasta)

MARILGVGRS SASSLNNKED NESDVALLSP KDPNRVHTKE QLAHPASSNL DPSMQGLPAG 60
LSLDDFIPGH LRTHIGSSSR GTRVPVIRNG GSNTLNFQFH DPAPRTVCNG CPPPRRDGSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGGGGG ATGGCCAGGA TTCTTGGAGT GGGAAGATCT TCAGCTTCGT CTTTGAACAA 60
CAAAGAAGAC AATGAAAGTG ATGTAGCCCT TCTTAGTCCC AAGGACCCTA ACAGGTGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR001452--SH3_domain
IPR003127--SoHo_dom
IPR028510--Vinexin

PROSITE

PS50002--SH3
PS50831--SOHO

Pfam

PF00018--SH3_1
PF14604--SH3_9
PF02208--Sorb

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3
SM00459--Sorb

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0008134--F:transcription factor binding
GO:0017166--F:vinculin binding
GO:0007015--P:actin filament organization
GO:0031589--P:cell-substrate adhesion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043410--P:positive regulation of MAPK cascade
GO:0051496--P:positive regulation of stress fiber assembly

KEGG

mmu:20410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001334	Ailuropoda melanoleuca	77.33	0.00e+00	1044.00
IUUC-Aca-004742	Anolis carolinensis	62.72	9.00e-91	326.00
IUUC-Ame-011484	Astyanax mexicanus	65.03	2.00e-54	206.00
IUUC-Bta-013006	Bos taurus	74.22	0.00e+00	960.00
IUUC-Cja-018889	Callithrix jacchus	77.91	0.00e+00	994.00
IUUC-Cfa-020116	Canis familiaris	72.04	0.00e+00	967.00
IUUC-Cpo-022410	Cavia porcellus	74.15	0.00e+00	962.00
IUUC-Csa-023880	Chlorocebus sabaeus	78.14	0.00e+00	1046.00
IUUC-Dre-027897	Danio rerio	42.31	7.00e-68	251.00
IUUC-Dor-031099	Dipodomys ordii	76.56	0.00e+00	976.00
IUUC-Ete-033119	Echinops telfairi	72.15	2.00e-95	343.00
IUUC-Eca-033308	Equus caballus	77.39	0.00e+00	1059.00
IUUC-Eeu-034908	Erinaceus europaeus	65.53	6.00e-169	587.00
IUUC-Fca-035613	Felis catus	73.67	0.00e+00	975.00
IUUC-Fal-036732	Ficedula albicollis	60.27	7.00e-94	338.00
IUUC-Gmo-039474	Gadus morhua	66.67	1.00e-52	201.00
IUUC-Ggo-045404	Gorilla gorilla	78.20	0.00e+00	1088.00
IUUC-Hsa-046435	Homo sapiens	78.92	0.00e+00	976.00
IUUC-Itr-048874	Ictidomys tridecemlineatus	77.21	0.00e+00	1050.00
IUUC-Lch-049463	Latimeria chalumnae	56.49	3.00e-87	314.00
IUUC-Loc-052576	Lepisosteus oculatus	41.19	1.00e-70	260.00
IUUC-Laf-053952	Loxodonta africana	75.64	0.00e+00	1026.00
IUUC-Mcc-055482	Macaca mulatta	79.36	0.00e+00	1016.00
IUUC-Meu-056517	Macropus eugenii	63.68	5.00e-122	431.00
IUUC-Mvi-060304	Microbotryum violaceum	35.81	6.00e-20	92.40
IUUC-Mmr-061231	Microcebus murinus	77.65	0.00e+00	1008.00
IUUC-Mdo-061965	Monodelphis domestica	58.20	0.00e+00	654.00
IUUC-Mpu-066398	Mustela putorius furo	77.49	0.00e+00	1069.00
IUUC-Mlu-067369	Myotis lucifugus	66.13	0.00e+00	852.00
IUUC-Nle-069995	Nomascus leucogenys	78.63	0.00e+00	999.00
IUUC-Opr-070845	Ochotona princeps	76.53	1.00e-83	303.00
IUUC-Ont-071643	Oreochromis niloticus	42.50	5.00e-77	282.00
IUUC-Oan-072838	Ornithorhynchus anatinus	66.46	4.00e-111	395.00
IUUC-Ocu-074532	Oryctolagus cuniculus	75.30	0.00e+00	986.00
IUUC-Ola-086962	Oryzias latipes	39.86	1.00e-61	231.00
IUUC-Oga-089133	Otolemur garnettii	75.67	0.00e+00	1035.00
IUUC-Oar-089690	Ovis aries	73.73	0.00e+00	989.00
IUUC-Ptr-091678	Pan troglodytes	79.51	0.00e+00	1024.00
IUUC-Pan-091746	Papio anubis	78.63	0.00e+00	1076.00
IUUC-Pfo-096778	Poecilia formosa	42.52	3.00e-74	273.00
IUUC-Pab-098678	Pongo abelii	79.22	0.00e+00	1006.00
IUUC-Pca-100286	Procavia capensis	73.44	0.00e+00	934.00
IUUC-Pva-102673	Pteropus vampyrus	76.89	0.00e+00	738.00
IUUC-Rno-105212	Rattus norvegicus	93.32	0.00e+00	1345.00
IUUC-Sha-107072	Sarcophilus harrisii	58.13	0.00e+00	690.00
IUUC-Ssc-116138	Sus scrofa	77.42	0.00e+00	1058.00
IUUC-Tsy-118791	Tarsius syrichta	82.47	9.00e-139	487.00
IUUC-Tbe-127945	Tupaia belangeri	80.99	2.00e-101	363.00
IUUC-Ttr-128675	Tursiops truncatus	83.28	4.00e-141	494.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence