iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064325

UUCD1 version

UUC-MuM-01031

Ensembl Protein ID

ENSMUSP00000105473.2

UniProt Accession

Q9WUB0; A2ANR4; Q3TM86; Q8C2I0; HOIL1_MOUSE

Genbank Protein ID

BAC40440.1; BAE38556.1; CAM24727.1; CAM24727.1; CAM23203.1; CAM23203.1; AAH34555.1; AAD24572.1

Protein Name

RanBP-type and C3HC4-type zinc finger-containing protein 1; Heme-oxidized IRP2 ubiquitin ligase 1 homolog; RING-type E3 ubiquitin transferase HOIL-1; UbcM4-interacting protein 28; Ubiquitin-conjugating enzyme 7-interacting protein 3

Genbank Nucleotide ID

AK088591; AK166075; AL831735; AL928568; AL928568; AL831735; BC034555; AF124663

Gene Name

Rbck1; Rbck; Ubce7ip3; Uip28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027466.15	ENSMUST00000109847.8	ENSMUSP00000105473.2
ENSMUSG00000027466.15	ENSMUST00000144865.1	ENSMUSP00000118592.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	6.30e-11	42.7	193	219
ULD/UDP/UBQ/UBQ_Other	1.10e-06	29.5	70	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C+ CTf+N+P +++CemC+r R+
   Q: 193  VGWQCPGCTFINKPTRPGCEMCCRARP 219
           68************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 14   tlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           t++  v p++tVa LK++++   g+pp  q++++ G+ L +d  tL ++g++
   Q: 70   TIWltVRPDMTVASLKDMVFLDYGFPPSLQQWVV-GQRLaRDQETLHSHGIR 120
           445559****************************.55555**********96 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (By similarity).

Protein Sequence
(Fasta)

MDEKTKKAEE MALSLARAVA GGDEQAAIKY ATWLAEQRVP LRVQVKPEVS PTQDIRLCVS 60
VEDAYMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPSLQQ WVVGQRLARD QETLHSHGIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGCTAGG CGCTGCCTGG AGTCGGCCGG GTGGGGGAGA GGGGGGGGAT CATGGGTCCC 60
TAGACCAAGT GACTCTGGTC CGCCCAACCA AGTGTGGCGC GAAAGTGCCA GGAGCAGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0043065--P:positive regulation of apoptotic process
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

KEGG

mmu:24105

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	88.63	0.00e+00	828.00
IUUC-Apl-003627	Anas platyrhynchos	58.11	5.00e-17	78.60
IUUC-Aca-004507	Anolis carolinensis	64.54	9.00e-154	536.00
IUUC-Ame-011008	Astyanax mexicanus	51.48	1.00e-142	499.00
IUUC-Bta-013247	Bos taurus	89.02	0.00e+00	850.00
IUUC-Bci-013637	Botrytis cinerea	26.34	2.00e-12	67.80
IUUC-Cja-018880	Callithrix jacchus	90.00	0.00e+00	863.00
IUUC-Cfa-020477	Canis familiaris	90.39	0.00e+00	861.00
IUUC-Cpo-021558	Cavia porcellus	89.02	0.00e+00	846.00
IUUC-Csa-024129	Chlorocebus sabaeus	90.59	0.00e+00	838.00
IUUC-Cin-025630	Ciona intestinalis	40.29	4.00e-82	298.00
IUUC-Csv-026069	Ciona savignyi	52.40	9.00e-75	273.00
IUUC-Dre-027591	Danio rerio	51.76	8.00e-141	493.00
IUUC-Dno-029015	Dasypus novemcinctus	88.24	0.00e+00	828.00
IUUC-Dor-030313	Dipodomys ordii	83.20	0.00e+00	742.00
IUUC-Ete-032908	Echinops telfairi	77.40	0.00e+00	714.00
IUUC-Eca-034295	Equus caballus	76.05	0.00e+00	712.00
IUUC-Eeu-034454	Erinaceus europaeus	83.39	6.00e-112	397.00
IUUC-Fca-036380	Felis catus	90.39	0.00e+00	857.00
IUUC-Fal-037440	Ficedula albicollis	56.60	3.00e-14	69.30
IUUC-Gmo-038561	Gadus morhua	54.11	4.00e-119	421.00
IUUC-Gga-040198	Gallus gallus	38.78	3.00e-28	119.00
IUUC-Gac-041319	Gasterosteus aculeatus	52.35	1.00e-138	486.00
IUUC-Ggo-044456	Gorilla gorilla	62.81	6.00e-147	514.00
IUUC-Hsa-045738	Homo sapiens	91.18	0.00e+00	838.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	90.77	0.00e+00	844.00
IUUC-Lch-050269	Latimeria chalumnae	45.76	1.00e-115	410.00
IUUC-Loc-052776	Lepisosteus oculatus	51.13	4.00e-136	478.00
IUUC-Laf-054269	Loxodonta africana	87.65	0.00e+00	841.00
IUUC-Mcc-055669	Macaca mulatta	91.18	0.00e+00	847.00
IUUC-Mga-059615	Meleagris gallopavo	53.12	9.00e-17	77.80
IUUC-Mmr-061562	Microcebus murinus	89.58	0.00e+00	746.00
IUUC-Mdo-062263	Monodelphis domestica	77.13	0.00e+00	744.00
IUUC-Mpu-066385	Mustela putorius furo	90.20	0.00e+00	857.00
IUUC-Mlu-067000	Myotis lucifugus	89.39	0.00e+00	835.00
IUUC-Nle-069812	Nomascus leucogenys	90.78	0.00e+00	840.00
IUUC-Opr-070575	Ochotona princeps	93.14	2.00e-105	375.00
IUUC-Ont-072405	Oreochromis niloticus	49.80	5.00e-134	471.00
IUUC-Ocu-074358	Oryctolagus cuniculus	80.35	0.00e+00	759.00
IUUC-Ola-086403	Oryzias latipes	52.19	5.00e-137	481.00
IUUC-Oga-087986	Otolemur garnettii	89.02	0.00e+00	821.00
IUUC-Oar-089600	Ovis aries	86.86	0.00e+00	848.00
IUUC-Ptr-091224	Pan troglodytes	90.98	0.00e+00	837.00
IUUC-Pan-092739	Papio anubis	91.37	0.00e+00	849.00
IUUC-Pma-094407	Petromyzon marinus	47.85	8.00e-127	447.00
IUUC-Pfo-097161	Poecilia formosa	51.26	8.00e-132	463.00
IUUC-Pab-098627	Pongo abelii	90.98	0.00e+00	832.00
IUUC-Pca-100641	Procavia capensis	86.79	0.00e+00	769.00
IUUC-Pva-102670	Pteropus vampyrus	88.82	0.00e+00	838.00
IUUC-Pte-104234	Pyrenophora teres	24.86	3.00e-11	63.20
IUUC-Rno-105504	Rattus norvegicus	96.85	0.00e+00	902.00
IUUC-Sha-107342	Sarcophilus harrisii	76.55	0.00e+00	757.00
IUUC-Sar-113425	Sorex araneus	87.21	5.00e-111	394.00
IUUC-Ssc-115904	Sus scrofa	90.17	4.00e-87	313.00
IUUC-Tru-118096	Takifugu rubripes	50.97	2.00e-138	486.00
IUUC-Tni-119873	Tetraodon nigroviridis	49.32	1.00e-138	486.00
IUUC-Tbe-127578	Tupaia belangeri	88.60	0.00e+00	672.00
IUUC-Ttr-129107	Tursiops truncatus	89.80	0.00e+00	822.00
IUUC-Vpa-130353	Vicugna pacos	90.69	3.00e-114	405.00
IUUC-Xtr-132168	Xenopus tropicalis	41.65	8.00e-92	330.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence