iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/NEDD8	NEDD8	9353319

Classification

Family	E-value	Score	Start	End
ULD/UBL/NEDD8	7.00e-44	149.6	1	76
ULD/UDP/UBQ/UBQ_PIM	4.20e-22	79.5	1	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           mlikvktLtgkeiei+ie++d++erikerveekeGiPP+qqrliy+Gkq++d+ktaady++ +gsvLhLvLaLrGG
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG 76
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++vktl+gke+e+++++ d+ve+ Ke+++++ g+pp+qq+LIy+Gk+++D++t  +++i  gsv+hlv+
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVL 71
           789******************************************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Protein Sequence
(Fasta)

MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK 60
ILGGSVLHLV LALRGGGGLR Q 81

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAACCGAAA CGCGGGAGCA ACCCTGAGCC TTTCCGGAAC CCAGTGGGGG GGGGGGGGGG 60
GGTGGAGCCA GACAGTGACC CGGAAGTAGA AGTGGCCCTT GCAGGCAAGA GTGCTGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0031625--F:ubiquitin protein ligase binding
GO:0009653--P:anatomical structure morphogenesis
GO:0006464--P:cellular protein modification process
GO:0016579--P:protein deubiquitination
GO:0008104--P:protein localization
GO:0045116--P:protein neddylation
GO:0006508--P:proteolysis
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0014070--P:response to organic cyclic compound
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:4738

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001930	Ailuropoda melanoleuca	98.33	6.00e-21	91.70
IUUC-Atr-003172	Amborella trichopoda	83.33	7.00e-33	131.00
IUUC-Ago-008002	Ashbya gossypii	64.47	7.00e-24	101.00
IUUC-Acl-008037	Aspergillus clavatus	78.95	9.00e-30	120.00
IUUC-Afu-008979	Aspergillus fumigatus	73.68	5.00e-28	115.00
IUUC-Ani-009466	Aspergillus nidulans	75.31	1.00e-29	120.00
IUUC-Ang-009839	Aspergillus niger	77.63	2.00e-29	119.00
IUUC-Ame-011045	Astyanax mexicanus	97.44	4.00e-30	122.00
IUUC-Bgr-011975	Blumeria graminis	72.37	1.00e-26	110.00
IUUC-Bta-013565	Bos taurus	95.31	3.00e-22	96.30
IUUC-Bci-013689	Botrytis cinerea	71.05	3.00e-19	86.30
IUUC-Cel-018445	Caenorhabditis elegans	88.16	1.00e-24	103.00
IUUC-Cja-019714	Callithrix jacchus	100.00	5.00e-24	102.00
IUUC-Cfa-020576	Canis familiaris	98.33	6.00e-21	91.70
IUUC-Cpo-022447	Cavia porcellus	93.85	3.00e-22	96.30
IUUC-Csa-023443	Chlorocebus sabaeus	93.83	4.00e-39	152.00
IUUC-Cho-024788	Choloepus hoffmanni	97.50	2.00e-31	126.00
IUUC-Cin-025290	Ciona intestinalis	90.79	6.00e-27	111.00
IUUC-Cgl-026712	Colletotrichum gloeosporioides	72.37	2.00e-26	109.00
IUUC-Cme-027142	Cyanidioschyzon merolae	75.00	6.00e-24	102.00
IUUC-Dre-028273	Danio rerio	95.00	7.00e-30	121.00
IUUC-Dor-030213	Dipodomys ordii	96.30	1.00e-30	124.00
IUUC-Dse-031407	Dothistroma septosporum	77.63	6.00e-29	118.00
IUUC-Dme-031610	Drosophila melanogaster	89.87	6.00e-37	144.00
IUUC-Ete-032442	Echinops telfairi	100.00	2.00e-31	126.00
IUUC-Eca-033619	Equus caballus	100.00	5.00e-24	102.00
IUUC-Eeu-035250	Erinaceus europaeus	100.00	5.00e-24	102.00
IUUC-Fca-036565	Felis catus	96.72	3.00e-21	92.40
IUUC-Fal-036836	Ficedula albicollis	90.91	2.00e-21	93.60
IUUC-Fox-037878	Fusarium oxysporum	73.68	3.00e-27	112.00
IUUC-Fso-038359	Fusarium solani	72.15	2.00e-27	113.00
IUUC-Gmo-038699	Gadus morhua	98.46	3.00e-23	99.40
IUUC-Ggr-039872	Gaeumannomyces graminis	75.00	9.00e-28	114.00
IUUC-Gga-041132	Gallus gallus	98.63	4.00e-28	116.00
IUUC-Gac-042098	Gasterosteus aculeatus	93.83	1.00e-29	120.00
IUUC-Ggo-044777	Gorilla gorilla	100.00	8.00e-21	91.30
IUUC-Hvu-047076	Hordeum vulgare	84.00	2.00e-22	96.70
IUUC-Itr-048900	Ictidomys tridecemlineatus	97.53	5.00e-32	128.00
IUUC-Lch-050564	Latimeria chalumnae	98.68	9.00e-30	120.00
IUUC-Lma-053069	Leptosphaeria maculans	78.95	2.00e-29	119.00
IUUC-Laf-053906	Loxodonta africana	93.83	9.00e-31	124.00
IUUC-Mcc-054619	Macaca mulatta	85.25	9.00e-24	101.00
IUUC-Meu-056784	Macropus eugenii	98.46	3.00e-23	99.40
IUUC-Mor-057128	Magnaporthe oryzae	77.63	1.00e-28	117.00
IUUC-Mpo-057329	Magnaporthe poae	76.32	3.00e-28	115.00
IUUC-Mla-058992	Melampsora laricipopulina	73.68	1.00e-20	90.50
IUUC-Mvi-060369	Microbotryum violaceum	69.74	2.00e-26	109.00
IUUC-Mdo-062773	Monodelphis domestica	95.08	2.00e-20	89.70
IUUC-Mmu-063552	Mus musculus	100.00	2.00e-24	103.00
IUUC-Mpu-065984	Mustela putorius furo	96.10	1.00e-29	120.00
IUUC-Nfi-068282	Neosartorya fischeri	73.68	5.00e-28	115.00
IUUC-Ncr-068922	Neurospora crassa	75.00	7.00e-28	114.00
IUUC-Ocu-074716	Oryctolagus cuniculus	100.00	5.00e-24	102.00
IUUC-Opu-083943	Oryza punctata	61.33	1.00e-21	94.40
IUUC-Olu-087844	Ostreococcus lucimarinus	88.00	1.00e-23	100.00
IUUC-Oar-089805	Ovis aries	96.72	4.00e-21	92.00
IUUC-Pan-092763	Papio anubis	100.00	5.00e-24	102.00
IUUC-Pno-095039	Phaeosphaeria nodorum	80.26	3.00e-30	122.00
IUUC-Pfo-096478	Poecilia formosa	98.68	5.00e-30	121.00
IUUC-Pab-098633	Pongo abelii	98.46	4.00e-23	99.00
IUUC-Pca-100180	Procavia capensis	100.00	5.00e-24	102.00
IUUC-Pva-102640	Pteropus vampyrus	100.00	5.00e-24	102.00
IUUC-Pgr-103621	Puccinia graminis	71.05	1.00e-26	110.00
IUUC-Pte-104313	Pyrenophora teres	78.95	7.00e-30	121.00
IUUC-Pyt-104549	Pyrenophora triticirepentis	77.63	3.00e-29	119.00
IUUC-Rno-105633	Rattus norvegicus	100.00	2.00e-24	103.00
IUUC-Sce-106190	Saccharomyces cerevisiae	58.44	3.00e-21	92.80
IUUC-Sha-107504	Sarcophilus harrisii	88.75	5.00e-28	115.00
IUUC-Sja-107751	Schizosaccharomyces japonicus	80.52	1.00e-31	127.00
IUUC-Spo-108180	Schizosaccharomyces pombe	81.58	3.00e-31	126.00
IUUC-Smo-108916	Selaginella moellendorffii	70.65	1.00e-22	98.20
IUUC-Sar-113327	Sorex araneus	100.00	5.00e-24	102.00
IUUC-Sre-114970	Sporisorium reilianum	82.89	8.00e-32	127.00
IUUC-Ssc-115698	Sus scrofa	93.75	2.00e-21	93.20
IUUC-Tru-118771	Takifugu rubripes	95.00	3.00e-30	122.00
IUUC-Tsy-118907	Tarsius syrichta	100.00	5.00e-24	102.00
IUUC-Tni-120655	Tetraodon nigroviridis	98.68	9.00e-30	120.00
IUUC-Tre-122155	Trichoderma reesei	73.68	4.00e-27	112.00
IUUC-Tvi-122440	Trichoderma virens	73.68	2.00e-27	113.00
IUUC-Tme-126933	Tuber melanosporum	76.32	7.00e-29	118.00
IUUC-Ttr-128587	Tursiops truncatus	92.75	3.00e-22	95.90
IUUC-Uma-129335	Ustilago maydis	82.89	1.00e-31	127.00
IUUC-Vda-129767	Verticillium dahliae	68.35	2.00e-26	109.00
IUUC-Vpa-130121	Vicugna pacos	96.92	9.00e-23	97.80
IUUC-Xtr-132345	Xenopus tropicalis	98.68	1.00e-29	120.00
IUUC-Xma-134074	Xiphophorus maculatus	97.18	1.00e-26	110.00
IUUC-Yli-134497	Yarrowia lipolytica	63.64	1.00e-24	104.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence