iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046880

UUCD1 version

UUC-HoS-00048

Ensembl Protein ID

ENSP00000343001.6

UniProt Accession

O95155; A8K8S9; G0ZJH6; O75169; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7; UBE4B_HUMAN

Genbank Protein ID

AAD02233.1; BAB40446.1; AAK69622.1; AEK06331.1; BAA31659.3; BAF85133.1; CAI14687.1; CAI14687.1; CAI14688.1; CAI14688.1; CAI21859.1; CAI21859.1; CAI21860.1; CAI21860.1; AAH93696.1; AAC72962.1

Protein Name

Ubiquitin conjugation factor E4 B; Homozygously deleted in neuroblastoma 1; RING-type E3 ubiquitin transferase E4 B; Ubiquitin fusion degradation protein 2

Genbank Nucleotide ID

AF043117; AB028839; AF331520; JF289274; AB014584; AK292444; AL590639; AL096841; AL590639; AL096841; AL096841; AL590639; AL096841; AL590639; BC093696; AF091093

Gene Name

UBE4B; HDNB1; KIAA0684; UFD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130939.18	ENST00000253251.12	ENSP00000253251.8
ENSG00000130939.18	ENST00000377153.5	ENSP00000366358.1
ENSG00000130939.18	ENST00000343090.10	ENSP00000343001.6
ENSG00000130939.18	ENST00000470736.1	ENSP00000467258.1
ENSG00000130939.18	ENST00000488228.1	ENSP00000468178.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	16484223; 21317885; 20696387

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.40e-21	78.0	1228	1299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
            p+ef++p++ +lM+dPv lpsG  +drs I ++l ++ + +P++rq+lte++l P  +l++ iqaw+ e+++
   Q: 1228 APDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPT-DPFNRQTLTESMLEPVPELKEQIQAWMREKQN 1299
           79**********************************9998.***************************99986 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Protein Sequence
(Fasta)

MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 60
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGGGGTGG GACGGAGGCG GGGAGAGGAC GCAGGCGAGA GGAACTCGGC GGCGCGGCGC 60
CCGCGGCCTA TTGGCTGCCA CGTCCCGGCG CCAGAAGCCC CGCCTCCCTG ACGGGGGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX

Pfam

PF04564--U-box
PF10408--Ufd2P_core

SMART

SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008626--P:granzyme-mediated apoptotic signaling pathway
GO:0031175--P:neuron projection development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0009411--P:response to UV
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0003222--P:ventricular trabecula myocardium morphogenesis

KEGG

hsa:10277

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000585	Aegilops tauschii	33.03	6.00e-95	342.00
IUUC-Aml-002396	Ailuropoda melanoleuca	98.88	0.00e+00	1734.00
IUUC-Atr-002479	Amborella trichopoda	32.02	7.00e-99	355.00
IUUC-Apl-003747	Anas platyrhynchos	94.05	0.00e+00	1671.00
IUUC-Aca-004866	Anolis carolinensis	93.93	0.00e+00	1657.00
IUUC-Aly-006300	Arabidopsis lyrata	30.65	2.00e-89	323.00
IUUC-Ath-006962	Arabidopsis thaliana	30.62	9.00e-87	315.00
IUUC-Ago-007880	Ashbya gossypii	29.30	2.00e-76	281.00
IUUC-Acl-008289	Aspergillus clavatus	30.41	1.00e-97	351.00
IUUC-Afl-008711	Aspergillus flavus	30.49	3.00e-102	367.00
IUUC-Afu-008766	Aspergillus fumigatus	30.87	1.00e-102	368.00
IUUC-Ani-009126	Aspergillus nidulans	30.44	2.00e-99	357.00
IUUC-Ang-009837	Aspergillus niger	30.33	2.00e-97	350.00
IUUC-Aor-009919	Aspergillus oryzae	30.06	7.00e-98	352.00
IUUC-Ate-010300	Aspergillus terreus	31.29	2.00e-104	374.00
IUUC-Ame-011355	Astyanax mexicanus	84.83	0.00e+00	1565.00
IUUC-Bgr-011995	Blumeria graminis	30.44	2.00e-100	360.00
IUUC-Bta-013056	Bos taurus	99.11	0.00e+00	1738.00
IUUC-Bci-013605	Botrytis cinerea	28.38	8.00e-86	312.00
IUUC-Bdi-015032	Brachypodium distachyon	30.52	1.00e-88	321.00
IUUC-Bol-016124	Brassica oleracea	30.75	6.00e-96	345.00
IUUC-Bra-017426	Brassica rapa	30.60	4.00e-96	346.00
IUUC-Cel-018606	Caenorhabditis elegans	30.81	1.00e-98	354.00
IUUC-Cja-018872	Callithrix jacchus	98.92	0.00e+00	2279.00
IUUC-Cfa-020045	Canis familiaris	98.77	0.00e+00	1732.00
IUUC-Cpo-022309	Cavia porcellus	98.21	0.00e+00	1728.00
IUUC-Cre-022726	Chlamydomonas reinhardtii	29.20	4.00e-49	189.00
IUUC-Csa-024003	Chlorocebus sabaeus	98.78	0.00e+00	1115.00
IUUC-Cho-025092	Choloepus hoffmanni	93.58	0.00e+00	1050.00
IUUC-Cin-025533	Ciona intestinalis	47.51	0.00e+00	825.00
IUUC-Csv-026081	Ciona savignyi	63.98	2.00e-60	224.00
IUUC-Cgl-026710	Colletotrichum gloeosporioides	30.98	1.00e-103	371.00
IUUC-Cne-027098	Cryptococcus neoformans	29.61	1.00e-103	372.00
IUUC-Cme-027352	Cyanidioschyzon merolae	32.64	1.00e-86	315.00
IUUC-Dre-027979	Danio rerio	84.25	0.00e+00	1506.00
IUUC-Dno-029282	Dasypus novemcinctus	98.99	0.00e+00	1735.00
IUUC-Dor-030904	Dipodomys ordii	81.36	0.00e+00	1084.00
IUUC-Dse-031393	Dothistroma septosporum	29.20	1.00e-94	341.00
IUUC-Dme-031666	Drosophila melanogaster	41.82	0.00e+00	681.00
IUUC-Ete-032519	Echinops telfairi	87.26	0.00e+00	722.00
IUUC-Eca-033778	Equus caballus	98.44	0.00e+00	1722.00
IUUC-Eeu-035315	Erinaceus europaeus	87.15	0.00e+00	1219.00
IUUC-Fca-035658	Felis catus	98.55	0.00e+00	1725.00
IUUC-Fal-037638	Ficedula albicollis	83.35	0.00e+00	1981.00
IUUC-Fox-037909	Fusarium oxysporum	29.06	6.00e-93	335.00
IUUC-Fso-038406	Fusarium solani	29.92	2.00e-94	341.00
IUUC-Gmo-039379	Gadus morhua	84.22	0.00e+00	1509.00
IUUC-Ggr-039851	Gaeumannomyces graminis	31.76	7.00e-104	372.00
IUUC-Gga-041136	Gallus gallus	94.14	0.00e+00	1674.00
IUUC-Gac-041910	Gasterosteus aculeatus	84.40	0.00e+00	1518.00
IUUC-Gma-043587	Glycine max	31.20	5.00e-92	332.00
IUUC-Ggo-045354	Gorilla gorilla	93.21	0.00e+00	1603.00
IUUC-Hvu-047157	Hordeum vulgare	33.20	1.00e-90	327.00
IUUC-Itr-048213	Ictidomys tridecemlineatus	98.80	0.00e+00	643.00
IUUC-Kpa-049211	Komagataella pastoris	27.80	9.00e-75	275.00
IUUC-Lch-050534	Latimeria chalumnae	87.98	0.00e+00	1607.00
IUUC-Lpe-051022	Leersia perrieri	31.14	2.00e-90	327.00
IUUC-Loc-052622	Lepisosteus oculatus	86.55	0.00e+00	1538.00
IUUC-Lma-053241	Leptosphaeria maculans	29.96	2.00e-94	340.00
IUUC-Laf-053646	Loxodonta africana	95.19	0.00e+00	2180.00
IUUC-Mcc-055588	Macaca mulatta	99.89	0.00e+00	1755.00
IUUC-Meu-055999	Macropus eugenii	74.28	0.00e+00	1627.00
IUUC-Mor-057064	Magnaporthe oryzae	30.68	3.00e-103	370.00
IUUC-Mpo-057452	Magnaporthe poae	31.98	7.00e-106	379.00
IUUC-Mtr-058016	Medicago truncatula	29.67	9.00e-99	355.00
IUUC-Mla-058887	Melampsora laricipopulina	33.05	8.00e-108	385.00
IUUC-Mga-059497	Meleagris gallopavo	93.92	0.00e+00	1667.00
IUUC-Mvi-060343	Microbotryum violaceum	34.39	5.00e-110	392.00
IUUC-Mmr-061173	Microcebus murinus	89.13	0.00e+00	1862.00
IUUC-Mdo-062102	Monodelphis domestica	95.50	0.00e+00	1682.00
IUUC-Mmu-063223	Mus musculus	97.77	0.00e+00	1724.00
IUUC-Mac-065531	Musa acuminata	31.21	3.00e-94	340.00
IUUC-Mpu-066624	Mustela putorius furo	66.78	0.00e+00	1051.00
IUUC-Mlu-068018	Myotis lucifugus	97.88	0.00e+00	1718.00
IUUC-Nfi-068590	Neosartorya fischeri	31.30	8.00e-104	372.00
IUUC-Ncr-068901	Neurospora crassa	32.54	5.00e-100	359.00
IUUC-Nle-069605	Nomascus leucogenys	98.56	0.00e+00	1738.00
IUUC-Opr-071011	Ochotona princeps	84.67	0.00e+00	853.00
IUUC-Ont-072304	Oreochromis niloticus	83.79	0.00e+00	1492.00
IUUC-Oan-073410	Ornithorhynchus anatinus	97.73	0.00e+00	1092.00
IUUC-Ocu-074910	Oryctolagus cuniculus	95.09	0.00e+00	2123.00
IUUC-Oba-075073	Oryza barthii	30.98	2.00e-96	347.00
IUUC-Obr-076452	Oryza brachyantha	31.27	4.00e-95	343.00
IUUC-Ogl-077141	Oryza glaberrima	30.98	9.00e-97	348.00
IUUC-Ogu-078116	Oryza glumaepatula	30.98	6.00e-97	349.00
IUUC-Oin-079066	Oryza indica	31.11	4.00e-97	349.00
IUUC-Olo-080253	Oryza longistaminata	29.02	5.00e-83	302.00
IUUC-Ome-081263	Oryza meridionalis	30.86	7.00e-96	345.00
IUUC-Oni-082019	Oryza nivara	31.11	6.00e-97	349.00
IUUC-Opu-083558	Oryza punctata	31.02	2.00e-97	350.00
IUUC-Oru-085002	Oryza rufipogon	30.98	1.00e-96	348.00
IUUC-Osa-085980	Oryza sativa	31.11	5.00e-97	349.00
IUUC-Ola-086323	Oryzias latipes	80.91	0.00e+00	1439.00
IUUC-Olu-087901	Ostreococcus lucimarinus	31.53	2.00e-97	350.00
IUUC-Oga-087969	Otolemur garnettii	94.74	0.00e+00	1637.00
IUUC-Oar-090020	Ovis aries	88.50	0.00e+00	2013.00
IUUC-Ptr-091589	Pan troglodytes	99.77	0.00e+00	2268.00
IUUC-Pan-091718	Papio anubis	100.00	0.00e+00	868.00
IUUC-Psi-093013	Pelodiscus sinensis	85.18	0.00e+00	2046.00
IUUC-Pma-094627	Petromyzon marinus	74.62	0.00e+00	629.00
IUUC-Pno-094840	Phaeosphaeria nodorum	29.93	8.00e-102	365.00
IUUC-Ppa-095989	Physcomitrella patens	29.34	3.00e-96	346.00
IUUC-Pfo-096436	Poecilia formosa	84.71	0.00e+00	1545.00
IUUC-Pab-098275	Pongo abelii	85.19	0.00e+00	1434.00
IUUC-Pop-098797	Populus trichocarpa	30.19	3.00e-100	360.00
IUUC-Pca-100478	Procavia capensis	80.35	0.00e+00	904.00
IUUC-Ppe-101230	Prunus persica	30.90	3.00e-101	363.00
IUUC-Pva-102459	Pteropus vampyrus	92.78	0.00e+00	2003.00
IUUC-Pgr-103485	Puccinia graminis	32.81	4.00e-108	386.00
IUUC-Ptt-104001	Puccinia triticina	42.17	2.00e-45	177.00
IUUC-Pte-104084	Pyrenophora teres	32.13	1.00e-109	391.00
IUUC-Pyt-104484	Pyrenophora triticirepentis	31.85	8.00e-109	388.00
IUUC-Rno-105719	Rattus norvegicus	97.87	0.00e+00	1721.00
IUUC-Sce-106135	Saccharomyces cerevisiae	36.49	1.00e-72	268.00
IUUC-Sha-106760	Sarcophilus harrisii	95.50	0.00e+00	1676.00
IUUC-Sja-107698	Schizosaccharomyces japonicus	32.66	9.00e-112	398.00
IUUC-Spo-108076	Schizosaccharomyces pombe	33.09	2.00e-106	380.00
IUUC-Ssl-108624	Sclerotinia sclerotiorum	29.19	2.00e-97	351.00
IUUC-Smo-109042	Selaginella moellendorffii	29.00	5.00e-89	322.00
IUUC-Sit-109949	Setaria italica	31.30	2.00e-92	334.00
IUUC-Sly-110973	Solanum lycopersicum	31.06	7.00e-84	305.00
IUUC-Stu-112372	Solanum tuberosum	30.03	2.00e-100	360.00
IUUC-Sar-113469	Sorex araneus	89.77	0.00e+00	1011.00
IUUC-Sbi-113828	Sorghum bicolor	31.47	8.00e-96	345.00
IUUC-Sre-114967	Sporisorium reilianum	32.25	3.00e-101	363.00
IUUC-Ssc-115655	Sus scrofa	97.74	0.00e+00	1107.00
IUUC-Tgu-117290	Taeniopygia guttata	93.60	0.00e+00	1624.00
IUUC-Tru-118193	Takifugu rubripes	74.76	0.00e+00	1768.00
IUUC-Tsy-118926	Tarsius syrichta	94.70	0.00e+00	2177.00
IUUC-Tni-120862	Tetraodon nigroviridis	85.46	0.00e+00	1504.00
IUUC-Tca-121096	Theobroma cacao	31.51	2.00e-100	360.00
IUUC-Tre-122104	Trichoderma reesei	30.47	2.00e-97	351.00
IUUC-Tvi-122345	Trichoderma virens	30.65	6.00e-101	363.00
IUUC-Tae-124607	Triticum aestivum	33.03	3.00e-95	343.00
IUUC-Tur-126056	Triticum urartu	33.03	8.00e-95	341.00
IUUC-Tme-127074	Tuber melanosporum	32.77	3.00e-97	350.00
IUUC-Tbe-127533	Tupaia belangeri	93.77	0.00e+00	1893.00
IUUC-Ttr-128757	Tursiops truncatus	93.25	0.00e+00	2138.00
IUUC-Uma-129550	Ustilago maydis	32.17	2.00e-102	367.00
IUUC-Vda-129901	Verticillium dahliae	30.29	9.00e-100	358.00
IUUC-Vpa-130636	Vicugna pacos	97.48	0.00e+00	1035.00
IUUC-Vvi-130891	Vitis vinifera	31.28	3.00e-100	360.00
IUUC-Xtr-132364	Xenopus tropicalis	87.27	0.00e+00	1576.00
IUUC-Xma-133772	Xiphophorus maculatus	84.60	0.00e+00	1543.00
IUUC-Yli-134506	Yarrowia lipolytica	30.68	1.00e-80	295.00
IUUC-Zma-135695	Zea mays	30.77	4.00e-87	316.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence