iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045849

UUCD1 version

UUC-HoS-01178

Ensembl Protein ID

ENSP00000354340.4

UniProt Accession

Q8TBC4; A6NLB5; A8K027; O76088; Q9NTU3; UBA3_HUMAN

Genbank Protein ID

CAB55996.2; BAG51021.1; BAF82081.1; EAW65470.1; AAH22853.1; AAC27648.1; BAA33144.1

Protein Name

NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3

Genbank Nucleotide ID

AL117566; AK002159; AK289392; AC092060; BC022853; AF046024; AB012190

Gene Name

UBA3; UBE1C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000144744.16	ENST00000415609.6	ENSP00000400294.2
ENSG00000144744.16	ENST00000361055.8	ENSP00000354340.4
ENSG00000144744.16	ENST00000349511.8	ENSP00000340041.4
ENSG00000144744.16	ENST00000461934.5	ENSP00000417547.1
ENSG00000144744.16	ENST00000465627.5	ENSP00000419077.1
ENSG00000144744.16	ENST00000631029.1	ENSP00000486366.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	16275315

Classification

Family	E-value	Score	Start	End
E1	1.10e-98	332.9	66	256

Active Site

Position(s)	Description	Evidence
237	Glycyl thioester intermediate	N/A

Domain Profile

   S: 15   klksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeeivF 106
            l+++kvl++GagglGcEllKnL+l+G+++i+v+Dmdt++vsnlnrqFLfr++d+g++KAevaae+l++++p++nv++h ++i++ +++  F
   Q: 66   LLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDT--F 155
           589***********************************************************************************999..* PP
   S: 107  fkkfdvVvlaldnrearrkvnrlclna............rvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpnaae 184
           +++f+++v++ld++ arr++n +++++             vpli++gt+G++G++rvi++g+t+c++c+   +ppq+++P+ct++++p+ +e
   Q: 156  YRQFHIIVCGLDSIIARRWINGMLISLlnyedgvldpssIVPLIDGGTEGFKGNARVILPGMTACIECTLelYPPQVNFPMCTIASMPRLPE 247
           **************************9***************************************************************** PP
   S: 185  htiewavlf 193
           h+ie+++++
   Q: 248  HCIEYVRML 256
           *****9443 PP

Organism

Homo sapiens

Functional Description
(View)

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Protein Sequence
(Fasta)

MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST 60
ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCTCCTC CCCGCCCTGC CGCGCGTGGG CACCTGGGAA GAGGCGGAGA ACAATATGGC 60
GGATGGCGAG GAGCCGTAAG TACCGGGGCT CTGCAGACGC GCCGGGCTGG GCTGGGTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014929--E2_binding
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR030468--Uba3
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF08825--E2_bind
PF00899--ThiF

SMART

SM01181--E2_bind

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016881--F:acid-amino acid ligase activity
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0046982--F:protein heterodimerization activity
GO:0006464--P:cellular protein modification process
GO:0007113--P:endomitotic cell cycle
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0045116--P:protein neddylation
GO:0006508--P:proteolysis
GO:0051726--P:regulation of cell cycle

KEGG

hsa:9039

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001124	Aegilops tauschii	47.73	4.00e-81	295.00
IUUC-Aml-001578	Ailuropoda melanoleuca	98.68	0.00e+00	942.00
IUUC-Atr-002591	Amborella trichopoda	50.37	2.00e-91	329.00
IUUC-Apl-003671	Anas platyrhynchos	90.34	0.00e+00	863.00
IUUC-Aca-004749	Anolis carolinensis	90.87	0.00e+00	827.00
IUUC-Aly-005747	Arabidopsis lyrata	47.64	3.00e-97	348.00
IUUC-Ath-006623	Arabidopsis thaliana	47.89	4.00e-97	348.00
IUUC-Ago-007934	Ashbya gossypii	45.28	4.00e-73	268.00
IUUC-Acl-008047	Aspergillus clavatus	50.12	3.00e-122	431.00
IUUC-Afl-008615	Aspergillus flavus	43.81	5.00e-79	288.00
IUUC-Afu-008996	Aspergillus fumigatus	50.94	1.00e-115	409.00
IUUC-Ani-009281	Aspergillus nidulans	43.76	1.00e-84	306.00
IUUC-Ang-009539	Aspergillus niger	51.06	1.00e-112	399.00
IUUC-Aor-010151	Aspergillus oryzae	48.44	6.00e-110	390.00
IUUC-Ate-010502	Aspergillus terreus	51.29	3.00e-114	405.00
IUUC-Ame-011837	Astyanax mexicanus	86.55	0.00e+00	791.00
IUUC-Bgr-012068	Blumeria graminis	50.71	9.00e-114	403.00
IUUC-Bta-013003	Bos taurus	98.92	0.00e+00	918.00
IUUC-Bci-013983	Botrytis cinerea	53.52	4.00e-124	437.00
IUUC-Bdi-014429	Brachypodium distachyon	49.00	1.00e-88	320.00
IUUC-Bol-015813	Brassica oleracea	48.64	2.00e-89	322.00
IUUC-Bra-018023	Brassica rapa	47.89	1.00e-86	313.00
IUUC-Cel-018684	Caenorhabditis elegans	53.27	2.00e-128	452.00
IUUC-Cja-019200	Callithrix jacchus	98.92	0.00e+00	913.00
IUUC-Cfa-021038	Canis familiaris	99.32	0.00e+00	919.00
IUUC-Cre-022778	Chlamydomonas reinhardtii	49.27	8.00e-108	384.00
IUUC-Csa-024079	Chlorocebus sabaeus	99.57	0.00e+00	923.00
IUUC-Cho-025052	Choloepus hoffmanni	90.50	0.00e+00	821.00
IUUC-Cin-025113	Ciona intestinalis	68.33	1.00e-180	625.00
IUUC-Csv-026231	Ciona savignyi	67.44	0.00e+00	629.00
IUUC-Cgl-026535	Colletotrichum gloeosporioides	50.92	2.00e-124	439.00
IUUC-Cne-026850	Cryptococcus neoformans	48.24	4.00e-108	384.00
IUUC-Cme-027275	Cyanidioschyzon merolae	36.22	2.00e-68	253.00
IUUC-Dre-028751	Danio rerio	86.55	0.00e+00	804.00
IUUC-Dno-029571	Dasypus novemcinctus	98.19	0.00e+00	911.00
IUUC-Dor-030395	Dipodomys ordii	97.62	0.00e+00	888.00
IUUC-Dse-031329	Dothistroma septosporum	45.52	5.00e-104	371.00
IUUC-Dme-031776	Drosophila melanogaster	64.27	3.00e-161	561.00
IUUC-Ete-032894	Echinops telfairi	77.65	2.00e-70	259.00
IUUC-Eca-034389	Equus caballus	95.90	0.00e+00	920.00
IUUC-Eeu-035152	Erinaceus europaeus	86.07	0.00e+00	691.00
IUUC-Fca-036032	Felis catus	99.10	0.00e+00	924.00
IUUC-Fal-037506	Ficedula albicollis	89.63	0.00e+00	859.00
IUUC-Fox-037871	Fusarium oxysporum	53.85	2.00e-110	392.00
IUUC-Fso-038350	Fusarium solani	52.08	2.00e-122	432.00
IUUC-Gmo-039246	Gadus morhua	84.02	0.00e+00	793.00
IUUC-Ggr-039859	Gaeumannomyces graminis	53.13	3.00e-120	425.00
IUUC-Gga-040843	Gallus gallus	87.89	0.00e+00	824.00
IUUC-Gac-042601	Gasterosteus aculeatus	84.23	0.00e+00	807.00
IUUC-Gma-042744	Glycine max	50.39	2.00e-88	319.00
IUUC-Ggo-044788	Gorilla gorilla	99.57	0.00e+00	916.00
IUUC-Hvu-047819	Hordeum vulgare	51.00	2.00e-82	299.00
IUUC-Itr-047863	Ictidomys tridecemlineatus	98.65	0.00e+00	915.00
IUUC-Kpa-049393	Komagataella pastoris	54.71	1.00e-103	369.00
IUUC-Lch-049471	Latimeria chalumnae	90.58	0.00e+00	837.00
IUUC-Lpe-051297	Leersia perrieri	48.32	9.00e-98	350.00
IUUC-Loc-052910	Lepisosteus oculatus	88.09	0.00e+00	814.00
IUUC-Lma-053181	Leptosphaeria maculans	49.66	9.00e-121	426.00
IUUC-Laf-054314	Loxodonta africana	97.86	0.00e+00	910.00
IUUC-Mcc-054870	Macaca mulatta	100.00	0.00e+00	921.00
IUUC-Meu-056574	Macropus eugenii	78.69	7.00e-131	460.00
IUUC-Mor-056919	Magnaporthe oryzae	53.95	5.00e-124	437.00
IUUC-Mpo-057614	Magnaporthe poae	54.44	9.00e-115	407.00
IUUC-Mtr-058110	Medicago truncatula	50.13	3.00e-89	322.00
IUUC-Mla-058949	Melampsora laricipopulina	52.81	9.00e-117	413.00
IUUC-Mga-059455	Meleagris gallopavo	90.28	0.00e+00	859.00
IUUC-Mvi-060270	Microbotryum violaceum	50.68	4.00e-119	421.00
IUUC-Mmr-061155	Microcebus murinus	93.38	0.00e+00	886.00
IUUC-Mdo-062037	Monodelphis domestica	95.46	0.00e+00	860.00
IUUC-Mmu-063670	Mus musculus	99.35	0.00e+00	920.00
IUUC-Mac-064711	Musa acuminata	48.39	3.00e-87	315.00
IUUC-Mpu-066734	Mustela putorius furo	98.65	0.00e+00	914.00
IUUC-Mlu-067068	Myotis lucifugus	98.49	0.00e+00	880.00
IUUC-Nfi-068349	Neosartorya fischeri	50.70	6.00e-115	407.00
IUUC-Ncr-068626	Neurospora crassa	52.75	3.00e-107	382.00
IUUC-Nle-069366	Nomascus leucogenys	91.88	0.00e+00	829.00
IUUC-Opr-070993	Ochotona princeps	93.85	4.00e-69	255.00
IUUC-Ont-072196	Oreochromis niloticus	85.56	0.00e+00	802.00
IUUC-Oan-073511	Ornithorhynchus anatinus	93.30	0.00e+00	880.00
IUUC-Ocu-073773	Oryctolagus cuniculus	99.14	0.00e+00	921.00
IUUC-Oba-075726	Oryza barthii	44.55	2.00e-85	309.00
IUUC-Obr-076286	Oryza brachyantha	47.36	2.00e-94	339.00
IUUC-Ogu-078473	Oryza glumaepatula	44.55	2.00e-85	310.00
IUUC-Oin-079393	Oryza indica	49.50	5.00e-100	358.00
IUUC-Olo-080446	Oryza longistaminata	46.15	4.00e-89	322.00
IUUC-Ome-081737	Oryza meridionalis	46.77	6.00e-89	321.00
IUUC-Oni-082853	Oryza nivara	44.55	2.00e-85	309.00
IUUC-Opu-083590	Oryza punctata	48.56	2.00e-99	356.00
IUUC-Oru-084184	Oryza rufipogon	44.55	2.00e-85	309.00
IUUC-Osa-085402	Oryza sativa	49.50	5.00e-100	358.00
IUUC-Ola-086615	Oryzias latipes	77.97	0.00e+00	736.00
IUUC-Olu-087738	Ostreococcus lucimarinus	48.40	3.00e-93	335.00
IUUC-Oga-088101	Otolemur garnettii	98.92	0.00e+00	918.00
IUUC-Oar-090293	Ovis aries	97.54	0.00e+00	909.00
IUUC-Ptr-090503	Pan troglodytes	100.00	0.00e+00	924.00
IUUC-Pan-092477	Papio anubis	97.64	0.00e+00	894.00
IUUC-Psi-093442	Pelodiscus sinensis	91.16	0.00e+00	857.00
IUUC-Pma-094247	Petromyzon marinus	80.58	0.00e+00	769.00
IUUC-Pno-094780	Phaeosphaeria nodorum	49.11	3.00e-114	405.00
IUUC-Ppa-095338	Physcomitrella patens	49.88	4.00e-116	411.00
IUUC-Pfo-097137	Poecilia formosa	85.13	0.00e+00	806.00
IUUC-Pab-098060	Pongo abelii	99.57	0.00e+00	884.00
IUUC-Pop-099470	Populus trichocarpa	47.44	4.00e-94	338.00
IUUC-Pca-100500	Procavia capensis	80.13	0.00e+00	739.00
IUUC-Ppe-102008	Prunus persica	48.44	1.00e-85	310.00
IUUC-Pva-103095	Pteropus vampyrus	99.57	1.00e-128	453.00
IUUC-Pgr-103666	Puccinia graminis	50.81	3.00e-115	409.00
IUUC-Ptt-103901	Puccinia triticina	51.29	1.00e-117	416.00
IUUC-Pte-104198	Pyrenophora teres	48.53	3.00e-119	421.00
IUUC-Pyt-104792	Pyrenophora triticirepentis	47.85	4.00e-117	414.00
IUUC-Rno-105446	Rattus norvegicus	99.35	0.00e+00	920.00
IUUC-Sce-106355	Saccharomyces cerevisiae	42.99	2.00e-71	262.00
IUUC-Sha-106664	Sarcophilus harrisii	95.27	0.00e+00	860.00
IUUC-Sja-107982	Schizosaccharomyces japonicus	43.02	4.00e-99	355.00
IUUC-Spo-108345	Schizosaccharomyces pombe	43.54	2.00e-98	352.00
IUUC-Ssl-108540	Sclerotinia sclerotiorum	48.94	9.00e-107	380.00
IUUC-Smo-109098	Selaginella moellendorffii	49.29	2.00e-115	409.00
IUUC-Sit-109724	Setaria italica	49.26	5.00e-91	328.00
IUUC-Sly-110916	Solanum lycopersicum	48.59	6.00e-95	341.00
IUUC-Stu-112236	Solanum tuberosum	48.33	1.00e-94	340.00
IUUC-Sar-113044	Sorex araneus	98.01	0.00e+00	818.00
IUUC-Sbi-114276	Sorghum bicolor	49.38	3.00e-91	328.00
IUUC-Sre-114963	Sporisorium reilianum	51.52	1.00e-117	416.00
IUUC-Ssc-116301	Sus scrofa	98.08	0.00e+00	912.00
IUUC-Tgu-117265	Taeniopygia guttata	89.42	0.00e+00	857.00
IUUC-Tru-117526	Takifugu rubripes	83.66	0.00e+00	787.00
IUUC-Tsy-119483	Tarsius syrichta	98.55	0.00e+00	850.00
IUUC-Tni-120363	Tetraodon nigroviridis	84.27	0.00e+00	782.00
IUUC-Tca-121731	Theobroma cacao	48.61	8.00e-88	317.00
IUUC-Tre-122221	Trichoderma reesei	53.32	2.00e-111	395.00
IUUC-Tvi-122352	Trichoderma virens	51.51	2.00e-123	435.00
IUUC-Tae-123864	Triticum aestivum	48.32	3.00e-90	325.00
IUUC-Tur-126070	Triticum urartu	45.82	6.00e-71	261.00
IUUC-Tme-127199	Tuber melanosporum	50.39	4.00e-109	388.00
IUUC-Tbe-128076	Tupaia belangeri	99.10	0.00e+00	918.00
IUUC-Ttr-128695	Tursiops truncatus	82.81	0.00e+00	747.00
IUUC-Uma-129638	Ustilago maydis	50.82	2.00e-117	415.00
IUUC-Vda-129963	Verticillium dahliae	51.96	9.00e-115	407.00
IUUC-Vpa-130637	Vicugna pacos	91.40	0.00e+00	825.00
IUUC-Vvi-131613	Vitis vinifera	48.46	7.00e-85	307.00
IUUC-Xtr-132924	Xenopus tropicalis	89.26	0.00e+00	818.00
IUUC-Xma-133356	Xiphophorus maculatus	85.13	0.00e+00	805.00
IUUC-Yli-134365	Yarrowia lipolytica	52.17	8.00e-111	394.00
IUUC-Zma-135941	Zea mays	44.90	8.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence