iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163930.9	ENST00000460680.5	ENSP00000417132.1
ENSG00000163930.9	ENST00000469613.5	ENSP00000418320.1
ENSG00000163930.9	ENST00000296288.9	ENSP00000296288.5
ENSG00000163930.9	ENST00000478368.1	ENSP00000420647.1
ENSG00000163930.9	ENST00000615113.1	ENSP00000482839.1

Annotation

Cancer Mutation
ICGC	COSMIC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
circBase	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	15314180

Classification

Family	E-value	Score	Start	End
DUB/UCH	8.40e-170	566.4	3	729

Active Site

Position(s)	Description	Evidence
91	Nucleophile	ECO:0000305}
169	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigN 97
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+i+N
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPN 89
           89***********************.************....************************************************** PP
   S: 98   sCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningr 189
           sCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsyv+i+gr
   Q: 90   SCATHALLSVLLNCSSV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGR 179
           *****************..************************************************************************* PP
   S: 190  lyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid.................. 259
           l+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++                  
   Q: 180  LFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealqqlirvtqpe 269
           *******************************..*********************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 270  liqthksqesqlpeesksasnksplvleanrapaasegnhtdgaeeaagscaqapshsppnkpklvvkppgsslngvhpnptpivqrlpafl 361
           ******************************************************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 362  dnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddeeddvqntnsalrykgkgtgkpgalsgsadgqlsvlqpntinvlaeklk 453
           ******************************************************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 454  esqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshiskvlfgeddsllrvdcir 545
           ******************************************************************************************** PP
   S: 260  ....................................................................................keLlkLlk 267
                                                                                               keLl+Llk
   Q: 546  ynravrdlgpvistgllhlaedgvlsplalteggkgsspsirpiqgsqgssspvekevveatdsrektgmvrpgeplsgekyspKELLALLK 637
           ******************************************************************************************** PP
   S: 268  dieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvnegrlakqrkqgrekkirplkrkrk 359
           ++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv++grl+kqrk++r+k++rp+k+kr+
   Q: 638  CVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ 729
           ******************************************************************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTCCGCCC CTCCCCTCGC AGCACCCGGG CCTAGTACTG CCCGTCCCGC CCCTCCTCTC 60
GAGCCTCAGC GCTCAGCATC GCCCGGACCC CCTCTTCCCT TCGCCCGCCT CGTCCCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006464--P:cellular protein modification process
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0008285--P:negative regulation of cell proliferation
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:8314

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	93.61	0.00e+00	1206.00
IUUC-Apl-003405	Anas platyrhynchos	69.79	0.00e+00	635.00
IUUC-Aca-004836	Anolis carolinensis	79.67	0.00e+00	1138.00
IUUC-Ame-011946	Astyanax mexicanus	63.20	0.00e+00	888.00
IUUC-Bta-013131	Bos taurus	91.11	0.00e+00	1073.00
IUUC-Cja-019599	Callithrix jacchus	97.53	0.00e+00	1360.00
IUUC-Cfa-021003	Canis familiaris	96.02	0.00e+00	1216.00
IUUC-Cpo-022143	Cavia porcellus	95.47	0.00e+00	1308.00
IUUC-Csa-023477	Chlorocebus sabaeus	98.35	0.00e+00	1339.00
IUUC-Cho-024734	Choloepus hoffmanni	83.20	0.00e+00	778.00
IUUC-Csv-025842	Ciona savignyi	58.95	1.00e-93	337.00
IUUC-Dre-027793	Danio rerio	65.17	0.00e+00	905.00
IUUC-Dno-029253	Dasypus novemcinctus	95.01	0.00e+00	1303.00
IUUC-Dor-030891	Dipodomys ordii	88.61	0.00e+00	1213.00
IUUC-Dme-031796	Drosophila melanogaster	60.82	7.00e-92	331.00
IUUC-Ete-032646	Echinops telfairi	85.71	6.00e-174	604.00
IUUC-Eca-033805	Equus caballus	94.79	0.00e+00	1259.00
IUUC-Eeu-035216	Erinaceus europaeus	93.54	2.00e-152	532.00
IUUC-Fca-035611	Felis catus	95.40	0.00e+00	1158.00
IUUC-Fal-037186	Ficedula albicollis	80.03	0.00e+00	990.00
IUUC-Gmo-038824	Gadus morhua	69.79	0.00e+00	632.00
IUUC-Gga-040875	Gallus gallus	81.64	0.00e+00	1117.00
IUUC-Gac-042226	Gasterosteus aculeatus	68.11	0.00e+00	936.00
IUUC-Ggo-045122	Gorilla gorilla	99.31	0.00e+00	1388.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	96.98	0.00e+00	1326.00
IUUC-Lch-049960	Latimeria chalumnae	72.42	0.00e+00	1004.00
IUUC-Loc-052408	Lepisosteus oculatus	74.68	0.00e+00	651.00
IUUC-Laf-054187	Loxodonta africana	96.02	0.00e+00	1266.00
IUUC-Mcc-055273	Macaca mulatta	97.39	0.00e+00	1336.00
IUUC-Meu-056267	Macropus eugenii	82.44	0.00e+00	1166.00
IUUC-Mga-059958	Meleagris gallopavo	87.25	6.00e-153	533.00
IUUC-Mmr-061280	Microcebus murinus	96.58	0.00e+00	1297.00
IUUC-Mdo-062625	Monodelphis domestica	89.16	0.00e+00	1275.00
IUUC-Mmu-063853	Mus musculus	92.73	0.00e+00	1270.00
IUUC-Mlu-067771	Myotis lucifugus	94.10	0.00e+00	1235.00
IUUC-Opr-070741	Ochotona princeps	93.42	0.00e+00	1284.00
IUUC-Ont-072172	Oreochromis niloticus	66.88	0.00e+00	947.00
IUUC-Oan-073167	Ornithorhynchus anatinus	80.52	0.00e+00	1149.00
IUUC-Ocu-074176	Oryctolagus cuniculus	94.91	0.00e+00	1236.00
IUUC-Ola-087203	Oryzias latipes	85.23	3.00e-135	474.00
IUUC-Oga-089153	Otolemur garnettii	96.26	0.00e+00	1311.00
IUUC-Oar-090008	Ovis aries	91.91	0.00e+00	1234.00
IUUC-Ptr-091234	Pan troglodytes	99.73	0.00e+00	1394.00
IUUC-Pan-092005	Papio anubis	98.35	0.00e+00	1363.00
IUUC-Psi-093995	Pelodiscus sinensis	83.68	0.00e+00	654.00
IUUC-Pma-094110	Petromyzon marinus	48.84	3.00e-119	422.00
IUUC-Pfo-097418	Poecilia formosa	66.05	0.00e+00	934.00
IUUC-Pab-098267	Pongo abelii	99.31	0.00e+00	1363.00
IUUC-Pca-101084	Procavia capensis	94.01	0.00e+00	1214.00
IUUC-Pva-102292	Pteropus vampyrus	95.53	0.00e+00	900.00
IUUC-Rno-105251	Rattus norvegicus	91.37	0.00e+00	1245.00
IUUC-Sha-107100	Sarcophilus harrisii	87.78	0.00e+00	1267.00
IUUC-Sar-113559	Sorex araneus	87.35	0.00e+00	1074.00
IUUC-Ssc-115688	Sus scrofa	94.65	0.00e+00	1295.00
IUUC-Tgu-117424	Taeniopygia guttata	80.58	0.00e+00	1119.00
IUUC-Tru-118585	Takifugu rubripes	66.49	0.00e+00	933.00
IUUC-Tsy-119299	Tarsius syrichta	84.87	0.00e+00	993.00
IUUC-Tni-120808	Tetraodon nigroviridis	66.98	0.00e+00	926.00
IUUC-Tbe-127705	Tupaia belangeri	95.16	0.00e+00	633.00
IUUC-Ttr-128225	Tursiops truncatus	94.51	0.00e+00	1242.00
IUUC-Vpa-130193	Vicugna pacos	94.58	1.00e-130	460.00
IUUC-Xtr-132449	Xenopus tropicalis	71.27	0.00e+00	948.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence