iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064422

UUCD1 version

UUC-MuM-00724

Ensembl Protein ID

ENSMUSP00000062344.7

UniProt Accession

Q8CCE9; Q05BH7; Q3UNJ9; Q62065; Q6IR08; Q6PGI1; Q9QY56; E4F1_MOUSE

Genbank Protein ID

AAF22563.1; BAC28222.1; BAE25748.1; AAH46459.1; AAH57011.1; AAH71228.1; CAA54188.1

Protein Name

Transcription factor E4F1; E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; Transcription factor phi AP3; p120E4F

Genbank Nucleotide ID

AF126967; AK033285; AK144176; BC046459; BC057011; BC071228; X76858

Gene Name

E4f1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024137.8	ENSMUST00000056032.7	ENSMUSP00000062344.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	87.73	0.00e+00	1177.00	IUUC-Hsa-046947

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.

Protein Sequence
(Fasta)

MEGAMAVRVT AAHTAEARAE AGREAGEGGV AAAAALSSGG FLGLPAPFSE EDEDDVHRCG 60
RCQVEFTALE DFVQHKIQKT CHRAPQEALP TTPAATALLD QEVVPTAAEG GPDEPITVAH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTTCCTGT GGCGCGTTGC GACATGGAGG GCGCGATGGC AGTGCGGGTG ACGGCCGCTC 60
ATACGGCAGA AGCCCGGGCC GAAGCCGGGC GTGAAGCGGG CGAGGGCGGG GTTGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0341--Growth regulation
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004039--Rubredoxin-type_fold
IPR013087--Znf_C2H2_type

PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

SMART

SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0035497--F:cAMP response element binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0016740--F:transferase activity
GO:0051301--P:cell division
GO:0006260--P:DNA replication
GO:0007067--P:mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0010564--P:regulation of cell cycle process
GO:0040008--P:regulation of growth
GO:0009794--P:regulation of mitotic cell cycle, embryonic
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:13560

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001466	Ailuropoda melanoleuca	84.51	0.00e+00	1075.00
IUUC-Apl-004190	Anas platyrhynchos	65.95	0.00e+00	919.00
IUUC-Aca-005100	Anolis carolinensis	59.92	0.00e+00	815.00
IUUC-Ame-010704	Astyanax mexicanus	56.75	2.00e-117	416.00
IUUC-Bta-013540	Bos taurus	87.23	0.00e+00	1165.00
IUUC-Cja-018918	Callithrix jacchus	86.24	0.00e+00	1165.00
IUUC-Cfa-020601	Canis familiaris	88.04	0.00e+00	644.00
IUUC-Cpo-021573	Cavia porcellus	89.37	0.00e+00	1252.00
IUUC-Csa-023729	Chlorocebus sabaeus	87.53	0.00e+00	1126.00
IUUC-Dre-028803	Danio rerio	44.52	4.00e-151	528.00
IUUC-Dno-030072	Dasypus novemcinctus	86.47	6.00e-174	604.00
IUUC-Dor-030640	Dipodomys ordii	84.57	0.00e+00	1068.00
IUUC-Eca-034223	Equus caballus	89.65	0.00e+00	1135.00
IUUC-Fca-036268	Felis catus	83.29	0.00e+00	1069.00
IUUC-Fal-037359	Ficedula albicollis	64.25	0.00e+00	791.00
IUUC-Gmo-039016	Gadus morhua	41.53	5.00e-118	418.00
IUUC-Gga-040305	Gallus gallus	65.38	0.00e+00	902.00
IUUC-Gac-042016	Gasterosteus aculeatus	45.31	1.00e-161	563.00
IUUC-Ggo-044459	Gorilla gorilla	87.52	0.00e+00	1097.00
IUUC-Hsa-046947	Homo sapiens	86.90	0.00e+00	1079.00
IUUC-Itr-048641	Ictidomys tridecemlineatus	90.64	0.00e+00	1149.00
IUUC-Lch-049557	Latimeria chalumnae	44.13	5.00e-156	545.00
IUUC-Loc-052894	Lepisosteus oculatus	50.13	0.00e+00	634.00
IUUC-Laf-053791	Loxodonta africana	82.52	0.00e+00	1110.00
IUUC-Mcc-054901	Macaca mulatta	87.15	0.00e+00	1113.00
IUUC-Meu-056299	Macropus eugenii	70.39	0.00e+00	944.00
IUUC-Mga-059323	Meleagris gallopavo	65.23	0.00e+00	924.00
IUUC-Mmr-061422	Microcebus murinus	89.54	0.00e+00	1152.00
IUUC-Mdo-061906	Monodelphis domestica	69.59	0.00e+00	949.00
IUUC-Mpu-066440	Mustela putorius furo	87.14	0.00e+00	1079.00
IUUC-Mlu-067352	Myotis lucifugus	87.25	0.00e+00	1132.00
IUUC-Nle-069201	Nomascus leucogenys	90.96	8.00e-179	620.00
IUUC-Opr-071166	Ochotona princeps	84.72	0.00e+00	1070.00
IUUC-Ont-071370	Oreochromis niloticus	45.96	2.00e-153	535.00
IUUC-Oan-072749	Ornithorhynchus anatinus	56.71	0.00e+00	672.00
IUUC-Ocu-074254	Oryctolagus cuniculus	87.57	0.00e+00	1145.00
IUUC-Ola-086897	Oryzias latipes	46.14	8.00e-164	570.00
IUUC-Oga-089179	Otolemur garnettii	88.21	0.00e+00	963.00
IUUC-Oar-090290	Ovis aries	74.73	0.00e+00	1061.00
IUUC-Ptr-091531	Pan troglodytes	85.01	0.00e+00	1025.00
IUUC-Pan-091839	Papio anubis	87.15	0.00e+00	1113.00
IUUC-Psi-093276	Pelodiscus sinensis	66.67	0.00e+00	746.00
IUUC-Pfo-096039	Poecilia formosa	49.30	3.00e-156	545.00
IUUC-Pca-100262	Procavia capensis	80.19	0.00e+00	1011.00
IUUC-Pva-102678	Pteropus vampyrus	84.95	0.00e+00	1097.00
IUUC-Rno-106036	Rattus norvegicus	96.50	0.00e+00	1276.00
IUUC-Sha-107571	Sarcophilus harrisii	70.08	0.00e+00	935.00
IUUC-Ssc-115849	Sus scrofa	88.44	0.00e+00	1099.00
IUUC-Tgu-117296	Taeniopygia guttata	65.35	0.00e+00	843.00
IUUC-Tru-118085	Takifugu rubripes	44.76	2.00e-156	546.00
IUUC-Tni-119719	Tetraodon nigroviridis	46.48	9.00e-168	583.00
IUUC-Ttr-129067	Tursiops truncatus	89.01	0.00e+00	1125.00
IUUC-Xtr-132116	Xenopus tropicalis	49.43	6.00e-174	604.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence