iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012948

Ensembl Protein ID

ENSBTAP00000046530.2

UniProt Accession

E1BDF2; SHRPN_BOVIN

Genbank Protein ID

ENSBTAP00000046530

Protein Name

Sharpin; Shank-associated RH domain-interacting protein

Genbank Nucleotide ID

AAFC03035445

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012235.4	ENSBTAT00000049670.2	ENSBTAP00000046530.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	5.00e-13	48.4	339	367
ULD/UDP/UBQ/UBQ_Other	1.00e-12	47.8	220	284

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W C++CTf+N+P++++CemCs++R+c
   Q: 339  QPGWPCPSCTFINAPSRPGCEMCSTQRPC 367
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk.dg 64
           qvtv+++ +s + +l+v+p++t+  L+e++++++g+pp+ qr+++ G++L  + ++La yg++ dg
   Q: 220  QVTVEDAASSaHVSLQVHPHCTIRALQEQVFSEFGFPPAVQRWVI-GRCLcVPEHSLAFYGVQrDG 284
           89*******************************************.**************885155 PP

Organism

Bos taurus

Functional Description
(View)

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity).

Protein Sequence
(Fasta)

MAPPAGGTAA GSDPGSAAVL LAVHVAVRPL GAGLDVAAQP RRLQLSADPE RPGRFRLEML 60
GAGPGAVILE WPLESVSYTV RGPCQHELQP PPGGPGTLSL HFANPQEAQR WAALVRDATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCTTCCC AGTTCCCCGG AGGGCCTAGT GGACTAGAGA GGCAACCGCG TGAGCGGCGG 60
GAGGTGGGCT GCGGCCCAGA AGGGGCTCCG GAGTAGCGTT CGGCTTGGGA GTTAGATACT 120

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Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0045202--C:synapse
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

KEGG

bta:512499

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	82.49	5.00e-138	483.00
IUUC-Apl-004151	Anas platyrhynchos	41.86	8.00e-17	77.80
IUUC-Ang-009713	Aspergillus niger	34.43	1.00e-03	37.70
IUUC-Cja-019031	Callithrix jacchus	79.39	1.00e-128	452.00
IUUC-Cfa-020863	Canis familiaris	76.77	2.00e-132	465.00
IUUC-Cpo-022499	Cavia porcellus	72.58	3.00e-125	441.00
IUUC-Csa-023641	Chlorocebus sabaeus	80.55	9.00e-131	459.00
IUUC-Dno-029459	Dasypus novemcinctus	59.16	9.00e-64	236.00
IUUC-Dor-030914	Dipodomys ordii	60.95	4.00e-79	288.00
IUUC-Ete-032940	Echinops telfairi	69.30	8.00e-103	367.00
IUUC-Eca-033537	Equus caballus	86.51	3.00e-152	531.00
IUUC-Eeu-035176	Erinaceus europaeus	69.74	9.00e-67	247.00
IUUC-Fca-035971	Felis catus	78.81	3.00e-144	504.00
IUUC-Gmo-039219	Gadus morhua	37.68	9.00e-52	197.00
IUUC-Gac-041562	Gasterosteus aculeatus	37.50	7.00e-37	147.00
IUUC-Ggo-044678	Gorilla gorilla	78.85	7.00e-128	450.00
IUUC-Hsa-046578	Homo sapiens	80.50	2.00e-132	465.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.63	4.00e-130	457.00
IUUC-Mcc-055686	Macaca mulatta	73.83	1.00e-128	452.00
IUUC-Meu-055912	Macropus eugenii	55.00	1.00e-67	249.00
IUUC-Mmr-060584	Microcebus murinus	77.47	1.00e-142	498.00
IUUC-Mdo-062191	Monodelphis domestica	56.46	2.00e-88	319.00
IUUC-Mmu-063740	Mus musculus	72.98	1.00e-118	419.00
IUUC-Mpu-066878	Mustela putorius furo	75.39	2.00e-128	451.00
IUUC-Mlu-067878	Myotis lucifugus	83.43	4.00e-144	503.00
IUUC-Nle-069748	Nomascus leucogenys	81.15	4.00e-127	447.00
IUUC-Ont-072270	Oreochromis niloticus	39.55	4.00e-51	195.00
IUUC-Obr-076087	Oryza brachyantha	58.33	2.00e-04	39.30
IUUC-Oga-088300	Otolemur garnettii	76.30	6.00e-145	506.00
IUUC-Oar-089549	Ovis aries	95.11	0.00e+00	684.00
IUUC-Ptr-090961	Pan troglodytes	80.60	8.00e-121	426.00
IUUC-Pan-092687	Papio anubis	81.59	7.00e-132	463.00
IUUC-Pfo-096865	Poecilia formosa	34.57	3.00e-41	162.00
IUUC-Pab-097872	Pongo abelii	76.97	3.00e-121	428.00
IUUC-Pca-100363	Procavia capensis	70.83	3.00e-72	265.00
IUUC-Pva-102595	Pteropus vampyrus	70.51	5.00e-124	437.00
IUUC-Pyt-104442	Pyrenophora triticirepentis	31.82	2.80e-02	32.00
IUUC-Rno-105856	Rattus norvegicus	71.71	8.00e-113	400.00
IUUC-Sha-106838	Sarcophilus harrisii	55.65	1.00e-81	296.00
IUUC-Sly-111366	Solanum lycopersicum	50.00	4.00e-05	42.00
IUUC-Sar-113611	Sorex araneus	65.96	1.00e-25	110.00
IUUC-Ssc-116263	Sus scrofa	83.46	4.00e-166	577.00
IUUC-Tru-118089	Takifugu rubripes	40.05	3.00e-59	222.00
IUUC-Tni-120004	Tetraodon nigroviridis	42.35	2.00e-50	192.00
IUUC-Tbe-127471	Tupaia belangeri	60.99	3.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence