iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089549

Ensembl Protein ID

ENSOARP00000016040.1

UniProt Accession

W5Q004; W5Q004_SHEEP

Genbank Protein ID

ENSOARP00000016040

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01110007

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014952.1	ENSOART00000016274.1	ENSOARP00000016040.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	5.50e-13	48.3	339	367
ULD/UDP/UBQ/UBQ_Other	3.70e-10	39.7	220	281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W C++CTf+N+P +++CemCs++R+c
   Q: 339  QPGWPCPSCTFINAPGRPGCEMCSTQRPC 367
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           qvtv+++ +s + +l+v+p++t+  L+e++++++g+pp+ q +++ G +L  + ++La yg++
   Q: 220  QVTVEDAASSaHVSLQVHPHCTIRALQEQVFSEFGFPPAVQCWVI-GSCLcVPEHSLAFYGVR 281
           89*******************************************.99**9*********995 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAPPAGGTAA GSDPGSAAVL LAVHAAVRPL GAGLDVEAQL RRLQLSADPE RPGRFRLEML 60
GAGPGAVSLE WPLESVSYTV RGPCQHELQP PPGGPGTLSL YFANPQEAQR WAALVRDATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGC CGGCGGGCGG CACAGCCGCT GGCTCGGACC CCGGCTCTGC CGCGGTGCTC 60
CTGGCCGTGC ATGCCGCGGT GAGGCCGCTG GGCGCCGGCC TGGACGTGGA GGCCCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

KEGG

oas:101115285

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	82.76	8.00e-136	476.00
IUUC-Apl-004151	Anas platyrhynchos	63.83	4.00e-16	75.50
IUUC-Acl-008308	Aspergillus clavatus	37.21	1.40e-01	30.80
IUUC-Ang-009713	Aspergillus niger	34.43	3.00e-04	39.30
IUUC-Bta-012948	Bos taurus	95.11	0.00e+00	667.00
IUUC-Bol-016604	Brassica oleracea	42.86	2.00e-03	37.00
IUUC-Cja-019031	Callithrix jacchus	79.39	3.00e-128	451.00
IUUC-Cfa-020863	Canis familiaris	76.53	4.00e-127	447.00
IUUC-Cpo-022499	Cavia porcellus	73.18	1.00e-120	426.00
IUUC-Csa-023641	Chlorocebus sabaeus	78.67	3.00e-124	437.00
IUUC-Dre-027612	Danio rerio	34.88	8.00e-45	174.00
IUUC-Dno-029459	Dasypus novemcinctus	59.16	9.00e-63	233.00
IUUC-Dor-030914	Dipodomys ordii	61.46	4.00e-79	288.00
IUUC-Ete-032940	Echinops telfairi	69.18	4.00e-98	351.00
IUUC-Eca-033537	Equus caballus	84.92	2.00e-148	518.00
IUUC-Eeu-035176	Erinaceus europaeus	69.74	3.00e-65	242.00
IUUC-Fca-035971	Felis catus	81.99	3.00e-140	491.00
IUUC-Gmo-039219	Gadus morhua	37.76	2.00e-46	179.00
IUUC-Gga-040198	Gallus gallus	44.30	2.00e-27	115.00
IUUC-Ggo-044678	Gorilla gorilla	78.57	2.00e-127	449.00
IUUC-Hsa-046578	Homo sapiens	79.94	2.00e-131	461.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.70	4.00e-129	454.00
IUUC-Mcc-055686	Macaca mulatta	73.18	9.00e-126	443.00
IUUC-Meu-055912	Macropus eugenii	54.64	5.00e-64	237.00
IUUC-Mmr-060584	Microcebus murinus	77.25	7.00e-136	476.00
IUUC-Mdo-062191	Monodelphis domestica	55.41	2.00e-86	312.00
IUUC-Mmu-063740	Mus musculus	72.75	4.00e-115	407.00
IUUC-Mpu-066878	Mustela putorius furo	77.47	6.00e-125	440.00
IUUC-Mlu-067878	Myotis lucifugus	84.00	3.00e-140	491.00
IUUC-Nle-069748	Nomascus leucogenys	80.19	1.00e-125	442.00
IUUC-Ont-072270	Oreochromis niloticus	38.60	7.00e-46	177.00
IUUC-Oin-079800	Oryza indica	42.55	1.00e-03	37.70
IUUC-Oni-082829	Oryza nivara	42.55	1.00e-03	37.70
IUUC-Oga-088300	Otolemur garnettii	76.82	2.00e-139	488.00
IUUC-Ptr-090961	Pan troglodytes	79.26	5.00e-119	420.00
IUUC-Pan-092687	Papio anubis	80.56	2.00e-128	451.00
IUUC-Pab-097872	Pongo abelii	76.67	4.00e-121	427.00
IUUC-Pca-100363	Procavia capensis	70.83	9.00e-72	263.00
IUUC-Pva-102595	Pteropus vampyrus	69.89	5.00e-123	434.00
IUUC-Pyt-104442	Pyrenophora triticirepentis	26.67	1.80e-01	29.30
IUUC-Rno-105856	Rattus norvegicus	71.79	6.00e-112	397.00
IUUC-Sha-106838	Sarcophilus harrisii	55.52	3.00e-81	295.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	37.21	2.70e-02	33.10
IUUC-Sar-113611	Sorex araneus	63.83	7.00e-23	100.00
IUUC-Ssc-116263	Sus scrofa	82.81	8.00e-160	556.00
IUUC-Tru-118089	Takifugu rubripes	40.24	2.00e-52	199.00
IUUC-Tni-120004	Tetraodon nigroviridis	40.40	5.00e-44	171.00
IUUC-Tbe-127471	Tupaia belangeri	62.53	1.00e-102	366.00
IUUC-Ttr-128534	Tursiops truncatus	71.55	6.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence