iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000034403.16	ENSMUST00000113792.1	ENSMUSP00000109423.1
ENSMUSG00000034403.16	ENSMUST00000113797.3	ENSMUSP00000109428.3
ENSMUSG00000034403.16	ENSMUST00000113790.7	ENSMUSP00000109421.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.00e-06	28.1	530	571

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++ +g     lpC H fh+ C+  w       +k+ +CP+Cr
   Q: 530  CPICCSEYVKGevATELPCHHYFHKPCVSIW------LQKSGTCPVCR 571
           ********4443233499*************......**********8 PP

Organism

Mus musculus

Functional Description
(View)

Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.

Protein Sequence
(Fasta)

MSHQERIASQ RRTTAEVPMH RSTANQSKRS RSPFASTRRR WDDSESSGAS LAVESEDYSR 60
YPPREYRASG SRRGLAYGHI DTVVARDSEE EGAGPVDRLP VRGKAGKFKD DPEKGARSSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGAACCT GTGCTGCCTG TAATGAACGA TCATCTCTTG CATAGACAAG CCTGGTTTTG 60
TGAGGAACAG CACCAGATTT CACTGTAAAC ACCTTCTGTT TGCCTCAAAC ACCAGGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031227--PJA1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030163--P:protein catabolic process

KEGG

mmu:18744

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002058	Ailuropoda melanoleuca	73.31	0.00e+00	738.00
IUUC-Apl-003808	Anas platyrhynchos	67.21	7.00e-60	223.00
IUUC-Aly-006436	Arabidopsis lyrata	45.21	2.00e-15	75.50
IUUC-Bdi-014634	Brachypodium distachyon	33.08	8.00e-15	73.60
IUUC-Bra-017306	Brassica rapa	45.21	1.00e-15	76.30
IUUC-Cja-019832	Callithrix jacchus	85.00	4.00e-109	388.00
IUUC-Cfa-020124	Canis familiaris	76.92	8.00e-131	459.00
IUUC-Csa-023998	Chlorocebus sabaeus	75.37	0.00e+00	746.00
IUUC-Cho-024393	Choloepus hoffmanni	62.15	5.00e-103	367.00
IUUC-Dno-029806	Dasypus novemcinctus	70.97	4.00e-162	564.00
IUUC-Ete-032338	Echinops telfairi	69.32	4.00e-169	587.00
IUUC-Eca-034421	Equus caballus	76.14	9.00e-132	462.00
IUUC-Fca-035465	Felis catus	75.17	0.00e+00	725.00
IUUC-Gma-042873	Glycine max	35.48	5.00e-18	84.30
IUUC-Ggo-044735	Gorilla gorilla	75.70	0.00e+00	759.00
IUUC-Hsa-046304	Homo sapiens	75.21	0.00e+00	756.00
IUUC-Itr-048973	Ictidomys tridecemlineatus	75.37	0.00e+00	772.00
IUUC-Laf-054182	Loxodonta africana	68.95	2.00e-172	598.00
IUUC-Mcc-055292	Macaca mulatta	75.51	0.00e+00	724.00
IUUC-Mmr-061024	Microcebus murinus	75.21	0.00e+00	720.00
IUUC-Mpu-066644	Mustela putorius furo	73.44	0.00e+00	758.00
IUUC-Mlu-067639	Myotis lucifugus	70.15	0.00e+00	710.00
IUUC-Ocu-073783	Oryctolagus cuniculus	78.55	1.00e-133	469.00
IUUC-Oga-088286	Otolemur garnettii	73.73	0.00e+00	762.00
IUUC-Oar-089497	Ovis aries	75.38	0.00e+00	753.00
IUUC-Pan-092534	Papio anubis	75.74	0.00e+00	717.00
IUUC-Rno-105580	Rattus norvegicus	91.93	1.00e-123	436.00
IUUC-Sbi-114059	Sorghum bicolor	43.42	4.00e-14	71.20
IUUC-Ssc-116194	Sus scrofa	74.79	0.00e+00	755.00
IUUC-Tsy-118954	Tarsius syrichta	67.70	3.00e-122	432.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence