iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000183763.8	ENST00000331456.6	ENSP00000328203.2
ENSG00000183763.8	ENST00000473195.5	ENSP00000419556.1
ENSG00000183763.8	ENST00000469027.5	ENSP00000420085.1
ENSG00000183763.8	ENST00000482582.5	ENSP00000418544.1
ENSG00000183763.8	ENST00000482243.1	ENSP00000419350.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17544371; 21068752

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.10e-06	27.8	7	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC + f   +d +    CgH+fh++Cl +w     ++ ++ +CP Cr
   Q: 7    CTICSDFFdhsRD-VAAIHCGHTFHLQCLIQW----FETAPSRTCPQCR 50
           9***776655344.88999*************....9***********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).

Protein Sequence
(Fasta)

MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN 60
KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTCCAGG AAGTCGTGCT GCGGAGCCAA ATTTGAAGCA AGCGGAGGCG CGGGGGCGCG 60
TCTACGAAGC CGGACCTGTA GCAGTTTCTT TGGCTGCCTG GGCCCCTTGA GTCCAGCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0242--Dwarfism
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0008283--P:cell proliferation
GO:0032688--P:negative regulation of interferon-beta production
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165--P:signal transduction

KEGG

hsa:10293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001411	Ailuropoda melanoleuca	81.78	0.00e+00	733.00
IUUC-Atr-002646	Amborella trichopoda	28.93	9.00e-08	52.00
IUUC-Apl-003777	Anas platyrhynchos	57.57	3.00e-109	388.00
IUUC-Aca-004476	Anolis carolinensis	57.32	2.00e-143	502.00
IUUC-Ame-011706	Astyanax mexicanus	49.30	2.00e-08	50.10
IUUC-Bta-013084	Bos taurus	81.53	0.00e+00	754.00
IUUC-Cel-018227	Caenorhabditis elegans	39.06	2.00e-11	63.50
IUUC-Cja-019856	Callithrix jacchus	94.24	0.00e+00	884.00
IUUC-Cfa-020075	Canis familiaris	84.65	0.00e+00	808.00
IUUC-Cpo-022481	Cavia porcellus	81.91	0.00e+00	772.00
IUUC-Csa-023793	Chlorocebus sabaeus	95.74	0.00e+00	918.00
IUUC-Csv-026190	Ciona savignyi	32.09	8.00e-42	164.00
IUUC-Dre-027984	Danio rerio	48.55	6.00e-121	427.00
IUUC-Dno-029478	Dasypus novemcinctus	83.55	0.00e+00	788.00
IUUC-Dor-030526	Dipodomys ordii	62.05	4.00e-162	564.00
IUUC-Dme-032130	Drosophila melanogaster	28.36	7.00e-22	98.60
IUUC-Ete-033012	Echinops telfairi	74.10	0.00e+00	664.00
IUUC-Eca-034084	Equus caballus	86.78	0.00e+00	832.00
IUUC-Eeu-034579	Erinaceus europaeus	76.05	2.00e-178	618.00
IUUC-Fca-035772	Felis catus	86.35	0.00e+00	801.00
IUUC-Fal-037098	Ficedula albicollis	59.51	2.00e-140	492.00
IUUC-Gmo-038704	Gadus morhua	46.88	5.00e-111	394.00
IUUC-Gga-041109	Gallus gallus	54.08	2.00e-136	479.00
IUUC-Gac-042636	Gasterosteus aculeatus	45.24	2.00e-114	405.00
IUUC-Ggo-045184	Gorilla gorilla	98.51	0.00e+00	945.00
IUUC-Itr-048550	Ictidomys tridecemlineatus	85.71	0.00e+00	830.00
IUUC-Lch-049575	Latimeria chalumnae	55.72	1.00e-127	449.00
IUUC-Loc-051999	Lepisosteus oculatus	49.33	2.00e-117	416.00
IUUC-Lma-053133	Leptosphaeria maculans	41.07	6.00e-08	51.20
IUUC-Laf-053347	Loxodonta africana	86.54	0.00e+00	818.00
IUUC-Mcc-054668	Macaca mulatta	94.39	3.00e-105	374.00
IUUC-Meu-056862	Macropus eugenii	63.03	8.00e-163	566.00
IUUC-Mga-059443	Meleagris gallopavo	55.04	2.00e-112	399.00
IUUC-Mmr-061219	Microcebus murinus	84.47	0.00e+00	790.00
IUUC-Mdo-062103	Monodelphis domestica	70.94	0.00e+00	649.00
IUUC-Mmu-064005	Mus musculus	79.70	0.00e+00	760.00
IUUC-Mac-064444	Musa acuminata	22.87	1.00e-06	47.80
IUUC-Mpu-066570	Mustela putorius furo	84.01	0.00e+00	781.00
IUUC-Mlu-067806	Myotis lucifugus	83.65	0.00e+00	785.00
IUUC-Nle-069123	Nomascus leucogenys	97.87	0.00e+00	920.00
IUUC-Opr-071063	Ochotona princeps	84.43	0.00e+00	808.00
IUUC-Ont-071973	Oreochromis niloticus	49.57	2.00e-120	425.00
IUUC-Oan-073278	Ornithorhynchus anatinus	69.86	6.00e-103	367.00
IUUC-Ocu-074582	Oryctolagus cuniculus	79.41	0.00e+00	729.00
IUUC-Oin-079866	Oryza indica	22.93	3.00e-07	50.40
IUUC-Osa-085981	Oryza sativa	23.84	3.00e-07	50.40
IUUC-Ola-086959	Oryzias latipes	47.83	1.00e-107	382.00
IUUC-Oga-088807	Otolemur garnettii	85.56	0.00e+00	776.00
IUUC-Oar-089273	Ovis aries	78.60	0.00e+00	736.00
IUUC-Ptr-090768	Pan troglodytes	98.93	0.00e+00	953.00
IUUC-Pan-091880	Papio anubis	95.95	0.00e+00	920.00
IUUC-Psi-093782	Pelodiscus sinensis	64.00	4.00e-137	481.00
IUUC-Pma-094365	Petromyzon marinus	38.90	3.00e-65	242.00
IUUC-Ppa-095896	Physcomitrella patens	25.12	2.00e-07	50.80
IUUC-Pfo-096068	Poecilia formosa	48.94	3.00e-110	391.00
IUUC-Pab-098063	Pongo abelii	95.32	0.00e+00	903.00
IUUC-Pca-100327	Procavia capensis	89.31	5.00e-180	623.00
IUUC-Pva-102924	Pteropus vampyrus	84.86	0.00e+00	794.00
IUUC-Pgr-103587	Puccinia graminis	42.86	5.00e-06	45.80
IUUC-Pte-104366	Pyrenophora teres	39.44	6.00e-07	48.10
IUUC-Rno-105799	Rattus norvegicus	81.41	0.00e+00	771.00
IUUC-Sha-107643	Sarcophilus harrisii	67.13	1.00e-160	559.00
IUUC-Sit-109687	Setaria italica	36.23	1.00e-06	48.10
IUUC-Sar-113187	Sorex araneus	78.09	0.00e+00	676.00
IUUC-Sbi-114760	Sorghum bicolor	36.23	1.00e-06	48.50
IUUC-Ssc-115838	Sus scrofa	89.79	8.00e-147	512.00
IUUC-Tgu-116674	Taeniopygia guttata	58.18	3.00e-128	451.00
IUUC-Tru-117753	Takifugu rubripes	45.42	5.00e-109	388.00
IUUC-Tsy-119416	Tarsius syrichta	72.83	1.00e-67	250.00
IUUC-Tni-120767	Tetraodon nigroviridis	47.43	2.00e-107	382.00
IUUC-Tur-126115	Triticum urartu	24.14	7.00e-07	50.10
IUUC-Tbe-128001	Tupaia belangeri	52.66	1.00e-85	310.00
IUUC-Ttr-128687	Tursiops truncatus	85.14	0.00e+00	811.00
IUUC-Xtr-131905	Xenopus tropicalis	53.72	1.00e-138	486.00
IUUC-Xma-133304	Xiphophorus maculatus	48.40	5.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence