iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.94	0.00e+00	741.00	IUUC-Hsa-046950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).

Protein Sequence
(Fasta)

MTSHSTSAQC SASDSACRIS SEQINQQVRP KLQLLKILQA AGAQGEVFTM KEVMHYLGQY 60
IMVKQLYDQQ EQHLVYCGGD LLGDLLGCQS FSVKDPSPLY DMLRKNLVTS ASVNTDAAQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTGCAGG CCTTAGGACC TTCAACTGCC ACCCCTCCCC CAGCTAGGAG GGGGGAGCGA 60
CTCATGGAGC GGCCGTAAGG TGTGGCGGTG GGGTCTGGTC CGCGGGGTGC GGGGAGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization

KEGG

rno:304798

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001467	Ailuropoda melanoleuca	83.77	0.00e+00	719.00
IUUC-Apl-003800	Anas platyrhynchos	60.85	3.00e-153	535.00
IUUC-Aca-004608	Anolis carolinensis	57.35	2.00e-136	479.00
IUUC-Ame-010869	Astyanax mexicanus	46.67	7.00e-104	370.00
IUUC-Bta-013287	Bos taurus	81.10	0.00e+00	770.00
IUUC-Cja-019305	Callithrix jacchus	82.52	0.00e+00	736.00
IUUC-Cfa-020393	Canis familiaris	83.16	0.00e+00	736.00
IUUC-Cpo-022166	Cavia porcellus	81.97	0.00e+00	688.00
IUUC-Csa-023654	Chlorocebus sabaeus	83.54	0.00e+00	719.00
IUUC-Cho-024403	Choloepus hoffmanni	81.27	1.00e-113	403.00
IUUC-Dre-027754	Danio rerio	46.84	1.00e-111	396.00
IUUC-Dno-029630	Dasypus novemcinctus	80.53	0.00e+00	745.00
IUUC-Dor-031064	Dipodomys ordii	65.17	1.00e-177	615.00
IUUC-Ete-032901	Echinops telfairi	72.82	0.00e+00	689.00
IUUC-Eca-034234	Equus caballus	84.35	0.00e+00	828.00
IUUC-Eeu-035015	Erinaceus europaeus	75.53	2.00e-80	293.00
IUUC-Fca-036587	Felis catus	83.54	0.00e+00	760.00
IUUC-Fal-036906	Ficedula albicollis	52.75	2.00e-131	462.00
IUUC-Gmo-038646	Gadus morhua	44.94	7.00e-100	357.00
IUUC-Gga-040124	Gallus gallus	58.65	2.00e-113	402.00
IUUC-Gac-042397	Gasterosteus aculeatus	45.90	2.00e-109	389.00
IUUC-Ggo-045505	Gorilla gorilla	83.74	0.00e+00	733.00
IUUC-Hsa-046950	Homo sapiens	83.94	0.00e+00	738.00
IUUC-Itr-048886	Ictidomys tridecemlineatus	81.71	0.00e+00	741.00
IUUC-Lch-050141	Latimeria chalumnae	52.48	2.00e-120	426.00
IUUC-Loc-051921	Lepisosteus oculatus	48.11	4.00e-112	398.00
IUUC-Laf-054281	Loxodonta africana	78.25	0.00e+00	704.00
IUUC-Mcc-055462	Macaca mulatta	80.28	0.00e+00	676.00
IUUC-Meu-056294	Macropus eugenii	70.93	3.00e-145	508.00
IUUC-Mga-059924	Meleagris gallopavo	60.12	2.00e-165	575.00
IUUC-Mmr-061428	Microcebus murinus	83.54	0.00e+00	790.00
IUUC-Mdo-062643	Monodelphis domestica	72.43	0.00e+00	694.00
IUUC-Mmu-063229	Mus musculus	94.90	0.00e+00	909.00
IUUC-Mpu-065782	Mustela putorius furo	82.59	0.00e+00	723.00
IUUC-Mlu-068105	Myotis lucifugus	75.20	0.00e+00	717.00
IUUC-Nle-069549	Nomascus leucogenys	83.94	0.00e+00	736.00
IUUC-Opr-070568	Ochotona princeps	82.37	0.00e+00	707.00
IUUC-Ont-072276	Oreochromis niloticus	47.71	9.00e-120	423.00
IUUC-Oan-072787	Ornithorhynchus anatinus	69.72	0.00e+00	640.00
IUUC-Ocu-074912	Oryctolagus cuniculus	82.93	0.00e+00	749.00
IUUC-Ola-087037	Oryzias latipes	45.34	2.00e-97	349.00
IUUC-Oga-088953	Otolemur garnettii	82.06	0.00e+00	743.00
IUUC-Oar-089202	Ovis aries	81.10	0.00e+00	776.00
IUUC-Ptr-090964	Pan troglodytes	83.74	0.00e+00	735.00
IUUC-Pan-091975	Papio anubis	83.74	0.00e+00	737.00
IUUC-Psi-093558	Pelodiscus sinensis	61.10	6.00e-157	546.00
IUUC-Pfo-096454	Poecilia formosa	48.39	6.00e-114	404.00
IUUC-Pab-098123	Pongo abelii	83.54	0.00e+00	737.00
IUUC-Pca-101112	Procavia capensis	71.95	0.00e+00	655.00
IUUC-Pva-103098	Pteropus vampyrus	75.41	0.00e+00	708.00
IUUC-Sha-107512	Sarcophilus harrisii	71.54	3.00e-179	621.00
IUUC-Sar-113584	Sorex araneus	74.13	0.00e+00	645.00
IUUC-Tgu-116766	Taeniopygia guttata	56.11	3.00e-101	361.00
IUUC-Tru-117829	Takifugu rubripes	47.37	3.00e-114	405.00
IUUC-Tsy-119268	Tarsius syrichta	71.14	3.00e-176	611.00
IUUC-Tni-120204	Tetraodon nigroviridis	47.06	7.00e-109	387.00
IUUC-Tbe-127840	Tupaia belangeri	78.57	3.00e-116	411.00
IUUC-Ttr-128863	Tursiops truncatus	80.89	0.00e+00	744.00
IUUC-Vpa-130718	Vicugna pacos	82.58	0.00e+00	723.00
IUUC-Xtr-132320	Xenopus tropicalis	46.97	2.00e-89	322.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence