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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045882
UUCD1 version UUC-HoS-01133
Ensembl Protein ID ENSP00000417132.1
UniProt Accession Q92560; A8K993; Q6LEM0; Q7Z5E8; BAP1_HUMAN
Genbank Protein ID AAC15970.1; BAB46921.1; BAA13401.2; BAF85297.1; EAW65220.1; AAH01596.1; AAN05092.1
Protein Name Ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; Cerebral protein 6
Genbank Nucleotide ID AF045581; D88812; D87462; AK292608; CH471055; BC001596; AY130008
Gene Name BAP1; KIAA0272; hucep-6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163930.9 ENST00000460680.5 ENSP00000417132.1
ENSG00000163930.9 ENST00000469613.5 ENSP00000418320.1
ENSG00000163930.9 ENST00000296288.9 ENSP00000296288.5
ENSG00000163930.9 ENST00000478368.1 ENSP00000420647.1
ENSG00000163930.9 ENST00000615113.1 ENSP00000482839.1
Annotation
Cancer Mutation
ICGCCOSMIC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
circBaseCircNetmiRTarBasemicroRNA
TRANSFACTargetScan
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/UCH UCH 15314180
Classification
Family E-value Score Start End
DUB/UCH 8.40e-170 566.4 3 729
Active Site
Position(s) Description Evidence
91 Nucleophile ECO:0000305}
169 Proton donor ECO:0000250}
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigN 97
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+i+N
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPN 89
           89***********************.************....************************************************** PP
   S: 98   sCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningr 189
           sCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsyv+i+gr
   Q: 90   SCATHALLSVLLNCSSV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGR 179
           *****************..************************************************************************* PP
   S: 190  lyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid.................. 259
           l+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++                  
   Q: 180  LFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealqqlirvtqpe 269
           *******************************..*********************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 270  liqthksqesqlpeesksasnksplvleanrapaasegnhtdgaeeaagscaqapshsppnkpklvvkppgsslngvhpnptpivqrlpafl 361
           ******************************************************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 362  dnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddeeddvqntnsalrykgkgtgkpgalsgsadgqlsvlqpntinvlaeklk 453
           ******************************************************************************************** PP
   S: 260  ............................................................................................ 259
                                                                                                       
   Q: 454  esqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshiskvlfgeddsllrvdcir 545
           ******************************************************************************************** PP
   S: 260  ....................................................................................keLlkLlk 267
                                                                                               keLl+Llk
   Q: 546  ynravrdlgpvistgllhlaedgvlsplalteggkgsspsirpiqgsqgssspvekevveatdsrektgmvrpgeplsgekyspKELLALLK 637
           ******************************************************************************************** PP
   S: 268  dieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvnegrlakqrkqgrekkirplkrkrk 359
           ++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv++grl+kqrk++r+k++rp+k+kr+
   Q: 638  CVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ 729
           ******************************************************************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045882|DUB,UCH|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTCCGCCC CTCCCCTCGC AGCACCCGGG CCTAGTACTG CCCGTCCCGC CCCTCCTCTC 60
GAGCCTCAGC GCTCAGCATC GCCCGGACCC CCTCTTCCCT TCGCCCGCCT CGTCCCGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045882|DUB,UCH|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006464--P:cellular protein modification process
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0008285--P:negative regulation of cell proliferation
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:8314
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001263 Ailuropoda melanoleuca 93.61 0.00e+00 1206.00
IUUC-Apl-003405 Anas platyrhynchos 69.79 0.00e+00 635.00
IUUC-Aca-004836 Anolis carolinensis 79.67 0.00e+00 1138.00
IUUC-Ame-011946 Astyanax mexicanus 63.20 0.00e+00 888.00
IUUC-Bta-013131 Bos taurus 91.11 0.00e+00 1073.00
IUUC-Cja-019599 Callithrix jacchus 97.53 0.00e+00 1360.00
IUUC-Cfa-021003 Canis familiaris 96.02 0.00e+00 1216.00
IUUC-Cpo-022143 Cavia porcellus 95.47 0.00e+00 1308.00
IUUC-Csa-023477 Chlorocebus sabaeus 98.35 0.00e+00 1339.00
IUUC-Cho-024734 Choloepus hoffmanni 83.20 0.00e+00 778.00
IUUC-Csv-025842 Ciona savignyi 58.95 1.00e-93 337.00
IUUC-Dre-027793 Danio rerio 65.17 0.00e+00 905.00
IUUC-Dno-029253 Dasypus novemcinctus 95.01 0.00e+00 1303.00
IUUC-Dor-030891 Dipodomys ordii 88.61 0.00e+00 1213.00
IUUC-Dme-031796 Drosophila melanogaster 60.82 7.00e-92 331.00
IUUC-Ete-032646 Echinops telfairi 85.71 6.00e-174 604.00
IUUC-Eca-033805 Equus caballus 94.79 0.00e+00 1259.00
IUUC-Eeu-035216 Erinaceus europaeus 93.54 2.00e-152 532.00
IUUC-Fca-035611 Felis catus 95.40 0.00e+00 1158.00
IUUC-Fal-037186 Ficedula albicollis 80.03 0.00e+00 990.00
IUUC-Gmo-038824 Gadus morhua 69.79 0.00e+00 632.00
IUUC-Gga-040875 Gallus gallus 81.64 0.00e+00 1117.00
IUUC-Gac-042226 Gasterosteus aculeatus 68.11 0.00e+00 936.00
IUUC-Ggo-045122 Gorilla gorilla 99.31 0.00e+00 1388.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 96.98 0.00e+00 1326.00
IUUC-Lch-049960 Latimeria chalumnae 72.42 0.00e+00 1004.00
IUUC-Loc-052408 Lepisosteus oculatus 74.68 0.00e+00 651.00
IUUC-Laf-054187 Loxodonta africana 96.02 0.00e+00 1266.00
IUUC-Mcc-055273 Macaca mulatta 97.39 0.00e+00 1336.00
IUUC-Meu-056267 Macropus eugenii 82.44 0.00e+00 1166.00
IUUC-Mga-059958 Meleagris gallopavo 87.25 6.00e-153 533.00
IUUC-Mmr-061280 Microcebus murinus 96.58 0.00e+00 1297.00
IUUC-Mdo-062625 Monodelphis domestica 89.16 0.00e+00 1275.00
IUUC-Mmu-063853 Mus musculus 92.73 0.00e+00 1270.00
IUUC-Mlu-067771 Myotis lucifugus 94.10 0.00e+00 1235.00
IUUC-Opr-070741 Ochotona princeps 93.42 0.00e+00 1284.00
IUUC-Ont-072172 Oreochromis niloticus 66.88 0.00e+00 947.00
IUUC-Oan-073167 Ornithorhynchus anatinus 80.52 0.00e+00 1149.00
IUUC-Ocu-074176 Oryctolagus cuniculus 94.91 0.00e+00 1236.00
IUUC-Ola-087203 Oryzias latipes 85.23 3.00e-135 474.00
IUUC-Oga-089153 Otolemur garnettii 96.26 0.00e+00 1311.00
IUUC-Oar-090008 Ovis aries 91.91 0.00e+00 1234.00
IUUC-Ptr-091234 Pan troglodytes 99.73 0.00e+00 1394.00
IUUC-Pan-092005 Papio anubis 98.35 0.00e+00 1363.00
IUUC-Psi-093995 Pelodiscus sinensis 83.68 0.00e+00 654.00
IUUC-Pma-094110 Petromyzon marinus 48.84 3.00e-119 422.00
IUUC-Pfo-097418 Poecilia formosa 66.05 0.00e+00 934.00
IUUC-Pab-098267 Pongo abelii 99.31 0.00e+00 1363.00
IUUC-Pca-101084 Procavia capensis 94.01 0.00e+00 1214.00
IUUC-Pva-102292 Pteropus vampyrus 95.53 0.00e+00 900.00
IUUC-Rno-105251 Rattus norvegicus 91.37 0.00e+00 1245.00
IUUC-Sha-107100 Sarcophilus harrisii 87.78 0.00e+00 1267.00
IUUC-Sar-113559 Sorex araneus 87.35 0.00e+00 1074.00
IUUC-Ssc-115688 Sus scrofa 94.65 0.00e+00 1295.00
IUUC-Tgu-117424 Taeniopygia guttata 80.58 0.00e+00 1119.00
IUUC-Tru-118585 Takifugu rubripes 66.49 0.00e+00 933.00
IUUC-Tsy-119299 Tarsius syrichta 84.87 0.00e+00 993.00
IUUC-Tni-120808 Tetraodon nigroviridis 66.98 0.00e+00 926.00
IUUC-Tbe-127705 Tupaia belangeri 95.16 0.00e+00 633.00
IUUC-Ttr-128225 Tursiops truncatus 94.51 0.00e+00 1242.00
IUUC-Vpa-130193 Vicugna pacos 94.58 1.00e-130 460.00
IUUC-Xtr-132449 Xenopus tropicalis 71.27 0.00e+00 948.00
Created Date 25-Jun-2017

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