iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045680

UUCD1 version

UUC-HoS-00095

Ensembl Protein ID

ENSP00000412190.2

UniProt Accession

Q06587; A8JZZ0; Q5JP96; Q5SQW2; Q86V19; RING1_HUMAN

Genbank Protein ID

CAA78389.1; AAP36016.1; BAF82044.1; CAA20235.1; CAI95620.1; CAI17650.1; CAI18069.1; CAI41841.1; CAQ08246.1; CAQ10303.1; CAQ10314.1; CAQ10314.1; CAQ10355.1; CAQ10355.1; AAH02922.2; AAH51866.1

Protein Name

E3 ubiquitin-protein ligase RING1; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; Really interesting new gene 1 protein

Genbank Nucleotide ID

Z14000; BT007352; AK289355; AL031228; AL031228; AL713971; AL645940; AL844527; CR759786; CR759733; CR847841; CR547129; CR547129; CR847841; BC002922; BC051866

Gene Name

RING1; RNF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000226788.3	ENST00000415941.2	ENSP00000412190.2

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	CircNet	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18643987; 19956605

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.70e-06	30.1	48	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+ dC+  ++       s++  CP+Cr
   Q: 48   CPICLDMLKNTMTTKECLHRFCSDCIvTAL------RSGNKECPTCR 88
           **********555555**********7777......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Protein Sequence
(Fasta)

MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT 60
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGTAGGGC CCCAGCGCCC GGGCCATGGC GGCGGCGGTG GCGGGAGCTG CTGTCTGAGC 60
AGCGGTTGCG GACCGAGCGA ACTTGGCCCA GGAGCCCGGG CCTAGGGAGA GGCGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0016740--F:transferase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0048593--P:camera-type eye morphogenesis
GO:0035518--P:histone H2A monoubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:6015

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001831	Ailuropoda melanoleuca	99.41	9.00e-99	353.00
IUUC-Aca-005261	Anolis carolinensis	59.31	1.00e-119	422.00
IUUC-Bta-012493	Bos taurus	99.31	4.00e-83	301.00
IUUC-Cel-018573	Caenorhabditis elegans	50.00	4.00e-15	78.60
IUUC-Cja-019447	Callithrix jacchus	100.00	3.00e-99	355.00
IUUC-Cfa-020721	Canis familiaris	99.41	8.00e-99	353.00
IUUC-Cpo-022273	Cavia porcellus	98.82	2.00e-98	352.00
IUUC-Csa-023422	Chlorocebus sabaeus	100.00	4.00e-99	355.00
IUUC-Dno-028911	Dasypus novemcinctus	99.41	8.00e-99	353.00
IUUC-Dor-030457	Dipodomys ordii	82.35	7.00e-76	277.00
IUUC-Eca-033576	Equus caballus	99.41	9.00e-99	353.00
IUUC-Eeu-034880	Erinaceus europaeus	99.34	4.00e-87	315.00
IUUC-Fca-035789	Felis catus	99.41	9.00e-99	353.00
IUUC-Gma-044107	Glycine max	44.26	1.00e-23	104.00
IUUC-Ggo-045070	Gorilla gorilla	100.00	4.00e-99	355.00
IUUC-Itr-048166	Ictidomys tridecemlineatus	99.41	9.00e-99	353.00
IUUC-Laf-054431	Loxodonta africana	99.41	7.00e-99	353.00
IUUC-Mcc-055268	Macaca mulatta	100.00	4.00e-99	355.00
IUUC-Meu-056000	Macropus eugenii	91.18	1.00e-153	536.00
IUUC-Mmr-061509	Microcebus murinus	98.82	4.00e-98	351.00
IUUC-Mdo-063069	Monodelphis domestica	91.39	4.00e-147	514.00
IUUC-Mmu-063462	Mus musculus	96.55	1.00e-150	526.00
IUUC-Mac-064893	Musa acuminata	46.94	3.00e-24	106.00
IUUC-Mpu-066818	Mustela putorius furo	99.41	9.00e-99	353.00
IUUC-Mlu-067266	Myotis lucifugus	99.28	1.00e-78	286.00
IUUC-Nle-069778	Nomascus leucogenys	100.00	4.00e-99	355.00
IUUC-Opr-070456	Ochotona princeps	90.94	4.00e-56	212.00
IUUC-Oga-088881	Otolemur garnettii	99.41	9.00e-99	353.00
IUUC-Oar-089484	Ovis aries	99.41	8.00e-99	353.00
IUUC-Ptr-091151	Pan troglodytes	100.00	4.00e-81	295.00
IUUC-Pan-092254	Papio anubis	100.00	4.00e-99	355.00
IUUC-Pab-098086	Pongo abelii	99.41	1.00e-98	353.00
IUUC-Pca-100649	Procavia capensis	97.06	3.00e-92	332.00
IUUC-Pte-104165	Pyrenophora teres	39.29	7.00e-06	45.10
IUUC-Rno-105941	Rattus norvegicus	96.80	4.00e-151	527.00
IUUC-Sha-106734	Sarcophilus harrisii	91.18	8.00e-166	576.00
IUUC-Smo-108741	Selaginella moellendorffii	51.95	7.00e-21	91.70
IUUC-Stu-112805	Solanum tuberosum	51.28	5.00e-20	92.80
IUUC-Ssc-116072	Sus scrofa	99.41	9.00e-99	353.00
IUUC-Ttr-128591	Tursiops truncatus	99.31	8.00e-83	300.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence