iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.12	0.00e+00	1950.00	IUUC-Hsa-045964
E3 activity/RING/RING	96.35	0.00e+00	2076.00	IUUC-Mmu-064297

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAVPLPSTLR LSSAPDEIQH PHIKFSEWKF KLFRVRSFEK APEEAQKEKD SSEGKPCLEQ 60
SPVVLDKPGG QNSVLTQRAL KLHPKFSKKF HVDGKSSDKA IHQARLRHFC RICGNHFKSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCTATCTC TGTGGCATCG AATATTAACA ACCAAACTGC AGACATTCTA ACACTCTGGC 60
CGGGAGGCCT GTGGAGCAAG GTAACTCTTG TGCTTTTCAT GCCTTGAGCC AAAATATTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0233--DNA recombination
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024627--RAG1
IPR019485--RAG1_Znf
IPR023336--RAG_nonamer-bd_dom
IPR013087--Znf_C2H2_type
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51487--NBD
PS51765--ZF_RAG1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12940--RAG1
PF00097--zf-C3HC4
PF10426--zf-RAG1

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0004519--F:endonuclease activity
GO:0043565--F:sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0010390--P:histone monoubiquitination
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0045582--P:positive regulation of T cell differentiation
GO:0002331--P:pre-B cell allelic exclusion
GO:0051865--P:protein autoubiquitination
GO:0033077--P:T cell differentiation in thymus
GO:0043029--P:T cell homeostasis
GO:0048538--P:thymus development
GO:0033151--P:V(D)J recombination

KEGG

rno:84600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001206	Ailuropoda melanoleuca	89.26	0.00e+00	1904.00
IUUC-Apl-003271	Anas platyrhynchos	75.61	0.00e+00	1646.00
IUUC-Aca-004400	Anolis carolinensis	73.11	0.00e+00	1618.00
IUUC-Ame-011295	Astyanax mexicanus	59.02	0.00e+00	1216.00
IUUC-Bta-012421	Bos taurus	89.12	0.00e+00	1895.00
IUUC-Cja-019891	Callithrix jacchus	88.88	0.00e+00	1884.00
IUUC-Cfa-020740	Canis familiaris	81.50	0.00e+00	1768.00
IUUC-Cpo-021800	Cavia porcellus	88.91	0.00e+00	1839.00
IUUC-Csa-024203	Chlorocebus sabaeus	88.58	0.00e+00	1681.00
IUUC-Dre-028416	Danio rerio	59.10	0.00e+00	1215.00
IUUC-Dno-029101	Dasypus novemcinctus	87.73	0.00e+00	1862.00
IUUC-Eca-033385	Equus caballus	89.73	0.00e+00	1918.00
IUUC-Fca-036545	Felis catus	88.97	0.00e+00	1894.00
IUUC-Fal-037208	Ficedula albicollis	73.95	0.00e+00	1634.00
IUUC-Gmo-039622	Gadus morhua	55.14	0.00e+00	1177.00
IUUC-Gga-041182	Gallus gallus	74.95	0.00e+00	1595.00
IUUC-Gac-041682	Gasterosteus aculeatus	56.90	0.00e+00	1207.00
IUUC-Ggo-044510	Gorilla gorilla	90.03	0.00e+00	1914.00
IUUC-Hsa-045964	Homo sapiens	89.84	0.00e+00	1912.00
IUUC-Itr-048862	Ictidomys tridecemlineatus	89.45	0.00e+00	1896.00
IUUC-Lch-050041	Latimeria chalumnae	69.40	0.00e+00	1482.00
IUUC-Loc-052464	Lepisosteus oculatus	63.55	0.00e+00	1375.00
IUUC-Laf-053544	Loxodonta africana	88.11	0.00e+00	1884.00
IUUC-Mcc-054867	Macaca mulatta	89.55	0.00e+00	1905.00
IUUC-Meu-055986	Macropus eugenii	79.49	0.00e+00	1556.00
IUUC-Mga-059262	Meleagris gallopavo	75.34	0.00e+00	1610.00
IUUC-Mdo-062686	Monodelphis domestica	79.75	0.00e+00	1754.00
IUUC-Mmu-064297	Mus musculus	96.35	0.00e+00	2076.00
IUUC-Mpu-066027	Mustela putorius furo	88.78	0.00e+00	1866.00
IUUC-Mlu-067885	Myotis lucifugus	89.74	0.00e+00	1910.00
IUUC-Nle-070073	Nomascus leucogenys	89.55	0.00e+00	1906.00
IUUC-Ont-071400	Oreochromis niloticus	61.74	0.00e+00	1274.00
IUUC-Oan-072920	Ornithorhynchus anatinus	93.65	0.00e+00	777.00
IUUC-Ocu-074616	Oryctolagus cuniculus	89.54	0.00e+00	1894.00
IUUC-Ola-086828	Oryzias latipes	59.98	0.00e+00	1254.00
IUUC-Oga-088675	Otolemur garnettii	91.88	1.00e-151	528.00
IUUC-Oar-090380	Ovis aries	88.49	0.00e+00	1907.00
IUUC-Ptr-090648	Pan troglodytes	90.03	0.00e+00	1917.00
IUUC-Pan-092036	Papio anubis	89.36	0.00e+00	1902.00
IUUC-Psi-093130	Pelodiscus sinensis	78.25	0.00e+00	1719.00
IUUC-Pfo-097273	Poecilia formosa	60.04	0.00e+00	1226.00
IUUC-Pca-100134	Procavia capensis	82.85	0.00e+00	1747.00
IUUC-Sha-107238	Sarcophilus harrisii	80.04	0.00e+00	1762.00
IUUC-Sar-113591	Sorex araneus	77.01	0.00e+00	1609.00
IUUC-Ssc-115720	Sus scrofa	88.11	0.00e+00	1882.00
IUUC-Tgu-117030	Taeniopygia guttata	74.37	0.00e+00	1616.00
IUUC-Tru-117669	Takifugu rubripes	57.80	0.00e+00	1149.00
IUUC-Tsy-119578	Tarsius syrichta	85.33	0.00e+00	1836.00
IUUC-Tni-120073	Tetraodon nigroviridis	57.25	0.00e+00	1199.00
IUUC-Tbe-128029	Tupaia belangeri	82.19	0.00e+00	924.00
IUUC-Ttr-128677	Tursiops truncatus	91.57	0.00e+00	801.00
IUUC-Vpa-130346	Vicugna pacos	93.00	0.00e+00	874.00
IUUC-Xtr-132442	Xenopus tropicalis	87.11	7.00e-100	355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence