iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000015837.15	ENSMUST00000015981.11	ENSMUSP00000015981.5
ENSMUSG00000015837.15	ENSMUST00000102774.10	ENSMUSP00000099835.4
ENSMUSG00000015837.15	ENSMUST00000136936.1	ENSMUSP00000120442.1
ENSMUSG00000015837.15	ENSMUST00000143379.1	ENSMUSP00000118662.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	14960283; 16079148; 16252010; 18382763

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.0011	20.1	398	432
ULD/UDP/UFD/PB1	6.20e-17	62.7	22	102

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAvey 37
           + l q+ +MGF d+  +l+ L+++ n+++ aA++ 
   Q: 398  ESLSQMLSMGFsDEGGWLTRLLQTkNYDIGAALDT 432
           6799*******6666*****************985 PP

ULD/UDP/UFD/PB1

   S: 3    rvkvsykgeirsfaldlekpgkfedLlkavrt.ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           r+ +++++e+++ a ++++pg +e+Ll++v+  ++ l+   ++ +Y+DedGDlv+++sDe+l++a+s+   k++++r++i++k
   Q: 22   RFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVlFPTLRPGGFQAHYRDEDGDLVAFSSDEELTMAMSY--VKDDIFRIYIKEK 102
           899*****************************9999999****************************7..9*********975 PP

Organism

Mus musculus

Functional Description
(View)

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

Protein Sequence
(Fasta)

MASFTVKAYL LGKEEATREI RRFSFCFSPE PEAEAQAAAG PGPCERLLSR VAVLFPTLRP 60
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRREHR PPCAQEAPRN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTCTATA AAAGCTGGGC TCTCGGCGCC GCCGCTGCCC AGCTGTTTCG TCCGTACCTA 60
GACCGCGGTT ATGGCGTCGT TCACGGTGAA GGCCTATCTT CTGGGCAAGG AGGAGGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000270--PB1_dom
IPR033741--SQSTM_UBA
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00564--PB1
PF16577--UBA_5
PF00569--ZZ

SMART

SM00666--PB1
SM00165--UBA
SM00291--ZnF_ZZ

Gene Ontology

GO:0016235--C:aggresome
GO:0044753--C:amphisome
GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0016234--C:inclusion body
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0000932--C:P-body
GO:0016605--C:PML body
GO:0000407--C:pre-autophagosomal structure
GO:0097225--C:sperm midpiece
GO:0042802--F:identical protein binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0019901--F:protein kinase binding
GO:0005080--F:protein kinase C binding
GO:0042169--F:SH2 domain binding
GO:0003712--F:transcription cofactor activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0002376--P:immune system process
GO:0016236--P:macroautophagy
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016239--P:positive regulation of macroautophagy
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051291--P:protein heterooligomerization
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061635--P:regulation of protein complex stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:18412

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001367	Ailuropoda melanoleuca	87.97	9.00e-171	592.00
IUUC-Apl-003897	Anas platyrhynchos	56.12	2.00e-120	425.00
IUUC-Aca-004699	Anolis carolinensis	49.24	4.00e-100	358.00
IUUC-Ame-010982	Astyanax mexicanus	71.30	8.00e-41	161.00
IUUC-Bta-012634	Bos taurus	88.24	0.00e+00	749.00
IUUC-Cel-018540	Caenorhabditis elegans	39.39	8.00e-10	59.30
IUUC-Cja-019684	Callithrix jacchus	88.01	0.00e+00	732.00
IUUC-Cfa-020573	Canis familiaris	81.82	5.00e-136	477.00
IUUC-Cpo-021425	Cavia porcellus	79.60	0.00e+00	629.00
IUUC-Csa-023968	Chlorocebus sabaeus	88.46	0.00e+00	714.00
IUUC-Cho-024596	Choloepus hoffmanni	81.53	2.00e-53	202.00
IUUC-Cin-025557	Ciona intestinalis	27.64	4.00e-14	72.00
IUUC-Csv-025974	Ciona savignyi	25.62	8.00e-14	71.20
IUUC-Dre-028621	Danio rerio	43.51	5.00e-95	341.00
IUUC-Dno-029060	Dasypus novemcinctus	83.86	0.00e+00	713.00
IUUC-Dor-030547	Dipodomys ordii	87.55	3.00e-135	474.00
IUUC-Ete-033201	Echinops telfairi	76.80	7.00e-162	563.00
IUUC-Eca-033456	Equus caballus	88.31	0.00e+00	676.00
IUUC-Eeu-035157	Erinaceus europaeus	80.85	7.00e-172	596.00
IUUC-Fca-035403	Felis catus	86.77	0.00e+00	702.00
IUUC-Fal-036798	Ficedula albicollis	55.83	2.00e-137	482.00
IUUC-Gmo-039619	Gadus morhua	41.33	2.00e-48	186.00
IUUC-Gga-040137	Gallus gallus	55.86	3.00e-135	475.00
IUUC-Gac-042410	Gasterosteus aculeatus	46.90	5.00e-99	354.00
IUUC-Ggo-044690	Gorilla gorilla	90.05	0.00e+00	721.00
IUUC-Hsa-046390	Homo sapiens	89.14	0.00e+00	717.00
IUUC-Itr-048536	Ictidomys tridecemlineatus	91.63	0.00e+00	782.00
IUUC-Lch-049658	Latimeria chalumnae	47.90	1.00e-114	406.00
IUUC-Loc-052589	Lepisosteus oculatus	47.26	1.00e-111	396.00
IUUC-Laf-053746	Loxodonta africana	78.79	0.00e+00	627.00
IUUC-Mcc-055635	Macaca mulatta	88.46	0.00e+00	725.00
IUUC-Meu-056528	Macropus eugenii	52.99	2.00e-108	385.00
IUUC-Mga-059458	Meleagris gallopavo	58.09	6.00e-122	430.00
IUUC-Mvi-060347	Microbotryum violaceum	51.16	1.00e-07	52.40
IUUC-Mmr-061539	Microcebus murinus	84.33	3.00e-136	478.00
IUUC-Mdo-063083	Monodelphis domestica	63.82	9.00e-154	536.00
IUUC-Mpu-065727	Mustela putorius furo	86.86	2.00e-180	624.00
IUUC-Mlu-067026	Myotis lucifugus	85.41	0.00e+00	628.00
IUUC-Nle-069356	Nomascus leucogenys	63.18	3.00e-120	424.00
IUUC-Opr-071091	Ochotona princeps	69.68	7.00e-96	344.00
IUUC-Ont-071864	Oreochromis niloticus	48.53	2.00e-103	369.00
IUUC-Oan-073308	Ornithorhynchus anatinus	62.96	2.00e-145	508.00
IUUC-Ocu-074110	Oryctolagus cuniculus	87.10	0.00e+00	726.00
IUUC-Ola-086944	Oryzias latipes	45.74	1.00e-39	155.00
IUUC-Oga-088869	Otolemur garnettii	86.38	0.00e+00	733.00
IUUC-Oar-089857	Ovis aries	88.33	0.00e+00	649.00
IUUC-Ptr-091640	Pan troglodytes	90.05	0.00e+00	720.00
IUUC-Pan-092831	Papio anubis	88.17	0.00e+00	714.00
IUUC-Psi-093925	Pelodiscus sinensis	55.63	1.00e-129	456.00
IUUC-Pma-094576	Petromyzon marinus	31.68	3.00e-32	132.00
IUUC-Pfo-097297	Poecilia formosa	45.22	3.00e-93	335.00
IUUC-Pab-098725	Pongo abelii	81.45	0.00e+00	639.00
IUUC-Pca-101106	Procavia capensis	85.75	0.00e+00	700.00
IUUC-Pva-102710	Pteropus vampyrus	83.16	0.00e+00	639.00
IUUC-Rno-105539	Rattus norvegicus	96.15	0.00e+00	837.00
IUUC-Sha-107469	Sarcophilus harrisii	61.54	1.00e-127	449.00
IUUC-Ssc-115526	Sus scrofa	90.50	0.00e+00	730.00
IUUC-Tgu-117194	Taeniopygia guttata	58.84	3.00e-121	427.00
IUUC-Tru-117896	Takifugu rubripes	48.31	2.00e-104	372.00
IUUC-Tni-119943	Tetraodon nigroviridis	47.24	1.00e-91	330.00
IUUC-Ttr-128676	Tursiops truncatus	88.69	0.00e+00	748.00
IUUC-Vda-129812	Verticillium dahliae	51.02	2.00e-07	50.80
IUUC-Vpa-130319	Vicugna pacos	96.00	7.00e-57	213.00
IUUC-Xtr-132907	Xenopus tropicalis	54.15	4.00e-131	461.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence