iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000022831.14	ENSMUST00000023531.14	ENSMUSP00000023531.8
ENSMUSG00000022831.14	ENSMUST00000164050.7	ENSMUSP00000127186.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-12	47.1	435	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++lydy+++ +deL++   d+++ i  e  degW++g  + +g  GlfP+n+v+ 
   Q: 435  IALYDYQGEGSDELSFDPDDIITDI--EMVDEGWWRG--QCRGHFGLFPANYVKL 485
           79**********************9..9*********..7*************85 PP

Organism

Mus musculus

Functional Description
(View)

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity).

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDILKK KELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVADVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAGCTGC TCTGTTACTT ACCCTGAAGT GGCAGCCGCT GGAGGGGGCG CCTGGTGTAG 60
ATGTGAAAAG CCGTAACCAG GAACCAGTAA AGGTGGGTGC TCTGAGCTGG GGGTTTTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0017124--F:SH3 domain binding
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

mmu:15163

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	80.20	0.00e+00	660.00
IUUC-Bta-012591	Bos taurus	88.55	2.00e-162	565.00
IUUC-Cja-019982	Callithrix jacchus	78.86	0.00e+00	647.00
IUUC-Cfa-020262	Canis familiaris	82.72	3.00e-176	611.00
IUUC-Cpo-021362	Cavia porcellus	83.16	0.00e+00	653.00
IUUC-Csa-023911	Chlorocebus sabaeus	88.52	3.00e-166	578.00
IUUC-Dor-030437	Dipodomys ordii	74.64	1.00e-166	579.00
IUUC-Ete-033160	Echinops telfairi	70.50	3.00e-138	484.00
IUUC-Eca-033269	Equus caballus	82.93	0.00e+00	688.00
IUUC-Eeu-035032	Erinaceus europaeus	68.62	8.00e-112	397.00
IUUC-Fca-035999	Felis catus	81.40	0.00e+00	712.00
IUUC-Gga-040335	Gallus gallus	68.20	8.00e-107	380.00
IUUC-Ggo-044505	Gorilla gorilla	87.99	4.00e-164	571.00
IUUC-Hsa-046728	Homo sapiens	87.43	4.00e-163	567.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	73.40	3.00e-135	475.00
IUUC-Laf-054202	Loxodonta africana	81.56	0.00e+00	644.00
IUUC-Mcc-055824	Macaca mulatta	87.99	8.00e-165	573.00
IUUC-Mmr-061281	Microcebus murinus	72.24	1.00e-154	539.00
IUUC-Mdo-062515	Monodelphis domestica	68.42	7.00e-144	503.00
IUUC-Mpu-066565	Mustela putorius furo	79.39	0.00e+00	641.00
IUUC-Mlu-066942	Myotis lucifugus	81.04	0.00e+00	642.00
IUUC-Nle-069436	Nomascus leucogenys	88.27	2.00e-165	575.00
IUUC-Opr-070288	Ochotona princeps	76.22	5.00e-159	553.00
IUUC-Ocu-074686	Oryctolagus cuniculus	82.28	5.00e-175	607.00
IUUC-Ola-086894	Oryzias latipes	59.79	1.00e-93	337.00
IUUC-Oga-088585	Otolemur garnettii	74.30	7.00e-176	610.00
IUUC-Oar-089686	Ovis aries	81.85	0.00e+00	650.00
IUUC-Ptr-090461	Pan troglodytes	88.27	5.00e-165	573.00
IUUC-Pan-091887	Papio anubis	88.27	4.00e-166	577.00
IUUC-Psi-093785	Pelodiscus sinensis	70.67	1.00e-114	407.00
IUUC-Pab-098222	Pongo abelii	87.71	1.00e-163	569.00
IUUC-Pca-100668	Procavia capensis	83.62	2.00e-151	529.00
IUUC-Pva-102767	Pteropus vampyrus	69.59	2.00e-150	525.00
IUUC-Rno-106001	Rattus norvegicus	91.77	0.00e+00	766.00
IUUC-Sha-106912	Sarcophilus harrisii	56.28	5.00e-135	474.00
IUUC-Sar-113338	Sorex araneus	73.20	2.00e-162	565.00
IUUC-Ssc-116027	Sus scrofa	82.19	0.00e+00	681.00
IUUC-Tgu-117472	Taeniopygia guttata	55.90	3.00e-142	498.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence