iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141968.7	ENST00000304076.6	ENSP00000302269.2
ENSG00000141968.7	ENST00000602142.5	ENSP00000472929.1
ENSG00000141968.7	ENST00000596764.5	ENSP00000469450.1
ENSG00000141968.7	ENST00000599806.5	ENSP00000472803.1
ENSG00000141968.7	ENST00000539284.2	ENSP00000443242.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-20	74.3	788	839

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 788  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRVGWFPANYVEE 839
           788**********************.89999******..9*************86 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with SHB (PubMed:12084069). Interacts with APS, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity).

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGTCGCT CCACAGGCGA GCAGGGCAGG CGTGCGGGCG GGTGGGTGGT GGAGGCTGCG 60
AGGGTGCACG GCCGGCCCTG GGCAGGCGGT AGCCATGGAG CTGTGGCGCC AATGCACCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0046934--F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0030168--P:platelet activation
GO:0043065--P:positive regulation of apoptotic process
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0043087--P:regulation of GTPase activity
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0031295--P:T cell costimulation
GO:0030217--P:T cell differentiation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:7409

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	80.99	0.00e+00	1247.00
IUUC-Cja-020009	Callithrix jacchus	98.22	0.00e+00	1692.00
IUUC-Cfa-020768	Canis familiaris	96.21	0.00e+00	1610.00
IUUC-Dno-029602	Dasypus novemcinctus	94.67	0.00e+00	1605.00
IUUC-Eca-033682	Equus caballus	95.62	0.00e+00	1610.00
IUUC-Fca-035629	Felis catus	95.27	0.00e+00	1669.00
IUUC-Gmo-039693	Gadus morhua	59.93	0.00e+00	975.00
IUUC-Gac-041567	Gasterosteus aculeatus	65.80	0.00e+00	1022.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	90.31	0.00e+00	1508.00
IUUC-Loc-051761	Lepisosteus oculatus	72.29	0.00e+00	1214.00
IUUC-Laf-054537	Loxodonta africana	94.44	0.00e+00	1611.00
IUUC-Mcc-054726	Macaca mulatta	98.93	0.00e+00	1704.00
IUUC-Mmr-060980	Microcebus murinus	94.20	0.00e+00	1617.00
IUUC-Mdo-061926	Monodelphis domestica	86.36	0.00e+00	1332.00
IUUC-Mmu-063942	Mus musculus	93.14	0.00e+00	1590.00
IUUC-Mpu-066000	Mustela putorius furo	96.21	0.00e+00	1612.00
IUUC-Mlu-067818	Myotis lucifugus	92.70	0.00e+00	1572.00
IUUC-Ont-072213	Oreochromis niloticus	67.45	0.00e+00	1125.00
IUUC-Ocu-074830	Oryctolagus cuniculus	78.47	0.00e+00	1180.00
IUUC-Ola-087345	Oryzias latipes	64.08	0.00e+00	1064.00
IUUC-Oga-089104	Otolemur garnettii	95.86	0.00e+00	1634.00
IUUC-Oar-089459	Ovis aries	94.67	0.00e+00	1619.00
IUUC-Ptr-090766	Pan troglodytes	100.00	0.00e+00	1596.00
IUUC-Pan-091994	Papio anubis	98.11	0.00e+00	1684.00
IUUC-Psi-093595	Pelodiscus sinensis	79.21	0.00e+00	1308.00
IUUC-Pfo-097210	Poecilia formosa	66.16	0.00e+00	1082.00
IUUC-Pab-098630	Pongo abelii	99.52	0.00e+00	1673.00
IUUC-Pva-102406	Pteropus vampyrus	94.32	0.00e+00	1557.00
IUUC-Rno-105763	Rattus norvegicus	90.06	0.00e+00	1521.00
IUUC-Sha-106683	Sarcophilus harrisii	86.41	0.00e+00	1528.00
IUUC-Sar-113457	Sorex araneus	79.73	0.00e+00	939.00
IUUC-Ssc-115338	Sus scrofa	95.76	0.00e+00	1534.00
IUUC-Tru-118199	Takifugu rubripes	64.46	0.00e+00	1021.00
IUUC-Tni-120548	Tetraodon nigroviridis	64.84	0.00e+00	1045.00
IUUC-Tbe-127235	Tupaia belangeri	71.23	9.00e-139	487.00
IUUC-Vpa-130066	Vicugna pacos	69.86	1.00e-82	301.00
IUUC-Xtr-132410	Xenopus tropicalis	72.27	0.00e+00	1240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence