iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000179526.16	ENST00000398712.6	ENSP00000381698.2
ENSG00000179526.16	ENST00000359551.6	ENSP00000352551.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	21455181
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	21455181; 22549881

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	2.10e-12	47.9	349	377
ULD/UDP/UBQ/UBQ_Other	2.10e-11	45.2	239	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           ++ W+C++CTf+N+P++++CemCs++R+c
   Q: 349  QPSWSCPSCTFINAPDRPGCEMCSTQRPC 377
           578*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           +  l+v+p++tVa L+e+++++lg+pp+ qr+++ G++L  + ++La+yg++++
   Q: 239  HVALQVHPHCTVAALQEQVFSELGFPPAVQRWVI-GRCLcVPERSLASYGVRQD 291
           56678*****************************.**************99754 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Protein Sequence
(Fasta)

MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRRLQLSADP ERPGRFRLEL 60
LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTTGCCA CTGTTGGCTG CTGGTCAAAA AGGGCAGGAC CTGCGACGGC TCCGTGAAAG 60
TCAACTCTGC GGGCAGGAAC TGGAAGTTCT GCCACCTACA GCCTCAGGTC CTCGACCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0071797--C:LUBAC complex
GO:0014069--C:postsynaptic density
GO:0031593--F:polyubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0007420--P:brain development
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

KEGG

hsa:81858

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	38.24	2.60e-02	32.70
IUUC-Aml-001223	Ailuropoda melanoleuca	81.89	8.00e-131	459.00
IUUC-Apl-004151	Anas platyrhynchos	68.09	1.00e-17	80.90
IUUC-Ang-009713	Aspergillus niger	32.79	2.40e-02	33.50
IUUC-Bta-012948	Bos taurus	80.50	2.00e-136	478.00
IUUC-Cel-018155	Caenorhabditis elegans	36.54	7.30e-02	29.30
IUUC-Cja-019031	Callithrix jacchus	91.36	7.00e-145	506.00
IUUC-Cfa-020863	Canis familiaris	76.04	4.00e-106	378.00
IUUC-Cpo-022499	Cavia porcellus	77.44	1.00e-126	446.00
IUUC-Csa-023641	Chlorocebus sabaeus	93.07	2.00e-150	525.00
IUUC-Dno-029459	Dasypus novemcinctus	59.63	1.00e-57	216.00
IUUC-Dor-030914	Dipodomys ordii	66.22	4.00e-87	315.00
IUUC-Ete-032940	Echinops telfairi	71.04	2.00e-96	345.00
IUUC-Eca-033537	Equus caballus	80.85	8.00e-133	466.00
IUUC-Eeu-035176	Erinaceus europaeus	70.41	4.00e-62	231.00
IUUC-Fca-035971	Felis catus	80.12	5.00e-124	437.00
IUUC-Gmo-039219	Gadus morhua	38.31	4.00e-48	185.00
IUUC-Gga-040198	Gallus gallus	43.67	6.00e-29	121.00
IUUC-Gac-041562	Gasterosteus aculeatus	54.81	5.00e-29	122.00
IUUC-Ggo-044678	Gorilla gorilla	94.78	1.00e-158	552.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	76.16	9.00e-136	476.00
IUUC-Mcc-055686	Macaca mulatta	84.17	1.00e-147	516.00
IUUC-Meu-055912	Macropus eugenii	51.00	1.00e-58	220.00
IUUC-Mmr-060584	Microcebus murinus	81.06	2.00e-142	498.00
IUUC-Mdo-062191	Monodelphis domestica	55.29	1.00e-79	290.00
IUUC-Mmu-063740	Mus musculus	72.70	8.00e-111	393.00
IUUC-Mpu-066878	Mustela putorius furo	75.70	1.00e-113	403.00
IUUC-Mlu-067878	Myotis lucifugus	80.50	3.00e-131	461.00
IUUC-Nle-069748	Nomascus leucogenys	94.89	4.00e-148	517.00
IUUC-Ont-072270	Oreochromis niloticus	41.03	2.00e-54	206.00
IUUC-Oga-088300	Otolemur garnettii	82.17	3.00e-145	508.00
IUUC-Oar-089549	Ovis aries	79.94	3.00e-135	475.00
IUUC-Ptr-090961	Pan troglodytes	98.33	4.00e-152	530.00
IUUC-Pan-092687	Papio anubis	93.89	1.00e-154	539.00
IUUC-Pab-097872	Pongo abelii	91.52	4.00e-146	511.00
IUUC-Pca-100363	Procavia capensis	72.08	2.00e-63	236.00
IUUC-Pva-102595	Pteropus vampyrus	79.59	4.00e-117	414.00
IUUC-Rno-105856	Rattus norvegicus	72.60	4.00e-112	397.00
IUUC-Sha-106838	Sarcophilus harrisii	54.13	6.00e-68	251.00
IUUC-Sar-113611	Sorex araneus	65.18	2.00e-27	115.00
IUUC-Ssc-116263	Sus scrofa	77.16	2.00e-134	472.00
IUUC-Tru-118089	Takifugu rubripes	42.70	5.00e-56	211.00
IUUC-Tni-120004	Tetraodon nigroviridis	42.66	1.00e-46	180.00
IUUC-Tbe-127471	Tupaia belangeri	74.92	1.00e-103	369.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence