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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046698
Ensembl Protein ID ENSP00000329419.4
UniProt Accession P35606; B4DZI8; COPB2_HUMAN
Genbank Protein ID CAA49900.1; BAG64100.1; EAW79040.1; AAH00326.1
Protein Name Coatomer subunit beta'; Beta'-coat protein; p102
Genbank Nucleotide ID X70476; AK302943; AC024933; BC000326
Gene Name COPB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000184432.9 ENST00000503326.5 ENSP00000426682.1
ENSG00000184432.9 ENST00000333188.9 ENSP00000329419.4
ENSG00000184432.9 ENST00000512309.1 ENSP00000422917.1
ENSG00000184432.9 ENST00000515006.5 ENSP00000423271.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.60e-33 112.6 183 224
UBD/Beta-Prp 1.10e-71 243.2 13 292
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+   +++++
   Q: 183  GHEKGVNCIDYysgGDkPYLISGADDRLVKIWDYQNKTCVQT 224
           8*********9999778****************999988875 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           ++++++++v+ +p +++++++ ++g++ vw+ +t++l+++++ ++ +v+a kf  ++++ vtg++D+ i+v++++t + vh +++h+d++++
   Q: 13   ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRC 104
           67899*************************************************************************************** PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfds 190
           ++++p++ ++++ s+d  i++wd+++++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl+g h++ v+++++ s
   Q: 105  IAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSSPNFTLEG-HEKGVNCIDYYS 195
           ****************************9999**********************************************9.*********888 PP
   S: 191  ng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvl 280
            g  ++l+sg++d+ vk+wd+q+++cv+tl+gh +nv++  f+p+  ++++gs+Dg++riW + +  l +tl++  ++v++va l+ ++nv 
   Q: 196  GGdkPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVA 287
           7777********************************************************************************99999988 PP
   S: 281  vlgse 285
           +  +e
   Q: 288  LGYDE 292
           54444 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.
 This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.
Protein Sequence
(Fasta)
MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60
RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPFILTSSDD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046698|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAACGACG GCCCTGCGCG CAGTTTGCGC AGGCGCTCCG GCCCTGGCCT CTGACTATCG 60
CGAGAATCGG CTCCCGGAAG TTCCACGTCA GTCAGTCTGA CGGTCAGTGG ATCGGTGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046698|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0030133--C:transport vesicle
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
GO:1901998--P:toxin transport
KEGG hsa:9276
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000654 Aegilops tauschii 52.93 0.00e+00 942.00
IUUC-Aml-002154 Ailuropoda melanoleuca 98.45 0.00e+00 1826.00
IUUC-Atr-003090 Amborella trichopoda 58.66 0.00e+00 1076.00
IUUC-Apl-003976 Anas platyrhynchos 94.27 0.00e+00 1725.00
IUUC-Aca-004301 Anolis carolinensis 94.58 0.00e+00 1718.00
IUUC-Aly-006508 Arabidopsis lyrata 60.36 0.00e+00 1094.00
IUUC-Ath-007630 Arabidopsis thaliana 61.94 0.00e+00 1103.00
IUUC-Ago-007914 Ashbya gossypii 46.07 0.00e+00 756.00
IUUC-Acl-008237 Aspergillus clavatus 56.51 0.00e+00 969.00
IUUC-Afl-008535 Aspergillus flavus 55.96 0.00e+00 916.00
IUUC-Afu-008845 Aspergillus fumigatus 54.80 0.00e+00 946.00
IUUC-Ani-009135 Aspergillus nidulans 55.95 0.00e+00 920.00
IUUC-Ang-009654 Aspergillus niger 56.18 0.00e+00 862.00
IUUC-Aor-009939 Aspergillus oryzae 54.77 0.00e+00 972.00
IUUC-Ate-010355 Aspergillus terreus 54.21 0.00e+00 924.00
IUUC-Ame-010922 Astyanax mexicanus 84.34 0.00e+00 1489.00
IUUC-Bgr-012249 Blumeria graminis 53.49 0.00e+00 934.00
IUUC-Bta-013579 Bos taurus 98.74 0.00e+00 1481.00
IUUC-Bci-013866 Botrytis cinerea 56.03 0.00e+00 934.00
IUUC-Bdi-015046 Brachypodium distachyon 60.85 0.00e+00 1105.00
IUUC-Bol-016271 Brassica oleracea 60.59 0.00e+00 1111.00
IUUC-Bra-017758 Brassica rapa 60.55 0.00e+00 1109.00
IUUC-Cel-018387 Caenorhabditis elegans 65.44 0.00e+00 1180.00
IUUC-Cja-019145 Callithrix jacchus 99.45 0.00e+00 1843.00
IUUC-Cfa-020564 Canis familiaris 99.01 0.00e+00 1832.00
IUUC-Cpo-022201 Cavia porcellus 97.13 0.00e+00 1808.00
IUUC-Cre-022938 Chlamydomonas reinhardtii 58.42 0.00e+00 986.00
IUUC-Csa-023383 Chlorocebus sabaeus 98.41 0.00e+00 1181.00
IUUC-Cho-024454 Choloepus hoffmanni 92.24 0.00e+00 1409.00
IUUC-Cin-025681 Ciona intestinalis 75.69 0.00e+00 1362.00
IUUC-Csv-026012 Ciona savignyi 76.66 0.00e+00 1333.00
IUUC-Cgl-026649 Colletotrichum gloeosporioides 52.34 0.00e+00 849.00
IUUC-Cne-026986 Cryptococcus neoformans 51.81 0.00e+00 919.00
IUUC-Cme-027219 Cyanidioschyzon merolae 48.57 0.00e+00 850.00
IUUC-Dre-027846 Danio rerio 93.14 0.00e+00 1669.00
IUUC-Dor-030462 Dipodomys ordii 92.78 0.00e+00 1273.00
IUUC-Dse-031268 Dothistroma septosporum 54.91 0.00e+00 958.00
IUUC-Dme-031791 Drosophila melanogaster 70.28 0.00e+00 1272.00
IUUC-Ete-033166 Echinops telfairi 88.71 0.00e+00 1018.00
IUUC-Eca-034180 Equus caballus 96.12 0.00e+00 1755.00
IUUC-Eeu-035086 Erinaceus europaeus 87.80 0.00e+00 892.00
IUUC-Fca-036265 Felis catus 98.68 0.00e+00 1819.00
IUUC-Fal-037202 Ficedula albicollis 95.08 0.00e+00 1664.00
IUUC-Fox-037711 Fusarium oxysporum 56.83 0.00e+00 894.00
IUUC-Fso-038268 Fusarium solani 56.29 0.00e+00 891.00
IUUC-Gmo-039046 Gadus morhua 92.42 0.00e+00 1649.00
IUUC-Ggr-039863 Gaeumannomyces graminis 55.54 0.00e+00 911.00
IUUC-Gga-041112 Gallus gallus 94.28 0.00e+00 1727.00
IUUC-Gac-041733 Gasterosteus aculeatus 92.54 0.00e+00 1611.00
IUUC-Gma-042910 Glycine max 62.35 0.00e+00 1116.00
IUUC-Ggo-044984 Gorilla gorilla 99.67 0.00e+00 1848.00
IUUC-Hvu-047669 Hordeum vulgare 70.90 1.00e-168 585.00
IUUC-Itr-048212 Ictidomys tridecemlineatus 96.35 0.00e+00 1772.00
IUUC-Kpa-049265 Komagataella pastoris 49.19 0.00e+00 863.00
IUUC-Lch-050473 Latimeria chalumnae 90.64 0.00e+00 1710.00
IUUC-Lpe-051579 Leersia perrieri 60.81 0.00e+00 1097.00
IUUC-Loc-052675 Lepisosteus oculatus 94.02 0.00e+00 1694.00
IUUC-Lma-053218 Leptosphaeria maculans 54.66 0.00e+00 931.00
IUUC-Laf-053757 Loxodonta africana 98.46 0.00e+00 1818.00
IUUC-Mcc-054859 Macaca mulatta 99.56 0.00e+00 1845.00
IUUC-Meu-056174 Macropus eugenii 95.30 0.00e+00 750.00
IUUC-Mor-057264 Magnaporthe oryzae 56.06 0.00e+00 896.00
IUUC-Mpo-057538 Magnaporthe poae 55.79 0.00e+00 924.00
IUUC-Mtr-058310 Medicago truncatula 62.47 0.00e+00 1126.00
IUUC-Mla-058937 Melampsora laricipopulina 53.44 0.00e+00 917.00
IUUC-Mga-059875 Meleagris gallopavo 94.06 0.00e+00 1723.00
IUUC-Mvi-060240 Microbotryum violaceum 51.68 0.00e+00 917.00
IUUC-Mmr-061261 Microcebus murinus 98.90 0.00e+00 1834.00
IUUC-Mdo-062076 Monodelphis domestica 95.36 0.00e+00 1755.00
IUUC-Mmu-063324 Mus musculus 98.23 0.00e+00 1815.00
IUUC-Mac-064636 Musa acuminata 59.95 0.00e+00 1083.00
IUUC-Mpu-065961 Mustela putorius furo 98.79 0.00e+00 1822.00
IUUC-Mlu-067059 Myotis lucifugus 98.16 0.00e+00 1749.00
IUUC-Nfi-068277 Neosartorya fischeri 54.51 0.00e+00 935.00
IUUC-Ncr-068659 Neurospora crassa 52.83 0.00e+00 913.00
IUUC-Nle-069034 Nomascus leucogenys 99.56 0.00e+00 1843.00
IUUC-Opr-070334 Ochotona princeps 98.50 0.00e+00 1522.00
IUUC-Ont-071563 Oreochromis niloticus 87.46 0.00e+00 1668.00
IUUC-Oan-073416 Ornithorhynchus anatinus 97.45 0.00e+00 1655.00
IUUC-Ocu-074522 Oryctolagus cuniculus 98.45 0.00e+00 1826.00
IUUC-Oba-075760 Oryza barthii 60.05 0.00e+00 1076.00
IUUC-Obr-076163 Oryza brachyantha 61.88 0.00e+00 1097.00
IUUC-Ogl-077450 Oryza glaberrima 61.26 0.00e+00 1104.00
IUUC-Ogu-078994 Oryza glumaepatula 60.05 0.00e+00 1076.00
IUUC-Oin-079856 Oryza indica 57.57 0.00e+00 1078.00
IUUC-Olo-080731 Oryza longistaminata 59.35 0.00e+00 1061.00
IUUC-Ome-081554 Oryza meridionalis 57.37 0.00e+00 999.00
IUUC-Oni-082324 Oryza nivara 60.05 0.00e+00 1075.00
IUUC-Opu-083400 Oryza punctata 56.06 0.00e+00 1067.00
IUUC-Oru-084829 Oryza rufipogon 60.05 0.00e+00 1075.00
IUUC-Osa-086026 Oryza sativa 61.26 0.00e+00 1107.00
IUUC-Ola-087245 Oryzias latipes 87.82 0.00e+00 1671.00
IUUC-Olu-087655 Ostreococcus lucimarinus 59.85 0.00e+00 1058.00
IUUC-Oga-088163 Otolemur garnettii 95.48 0.00e+00 1750.00
IUUC-Oar-089842 Ovis aries 98.52 0.00e+00 1811.00
IUUC-Ptr-090501 Pan troglodytes 99.67 0.00e+00 1846.00
IUUC-Pan-092011 Papio anubis 99.45 0.00e+00 1843.00
IUUC-Psi-093308 Pelodiscus sinensis 97.40 0.00e+00 1729.00
IUUC-Pma-094695 Petromyzon marinus 80.77 0.00e+00 1436.00
IUUC-Pno-094785 Phaeosphaeria nodorum 62.41 2.00e-112 400.00
IUUC-Ppa-095911 Physcomitrella patens 62.95 0.00e+00 1128.00
IUUC-Pfo-096587 Poecilia formosa 86.04 0.00e+00 1670.00
IUUC-Pab-097926 Pongo abelii 96.93 0.00e+00 1745.00
IUUC-Pop-099634 Populus trichocarpa 62.11 0.00e+00 1103.00
IUUC-Pca-100965 Procavia capensis 96.80 0.00e+00 1772.00
IUUC-Ppe-101470 Prunus persica 62.71 0.00e+00 1118.00
IUUC-Pva-102451 Pteropus vampyrus 92.18 0.00e+00 1271.00
IUUC-Pgr-103453 Puccinia graminis 54.31 0.00e+00 927.00
IUUC-Ptt-103868 Puccinia triticina 54.55 0.00e+00 925.00
IUUC-Pte-104274 Pyrenophora teres 55.45 0.00e+00 963.00
IUUC-Pyt-104794 Pyrenophora triticirepentis 54.92 0.00e+00 912.00
IUUC-Rno-105979 Rattus norvegicus 84.12 0.00e+00 1262.00
IUUC-Sce-106269 Saccharomyces cerevisiae 47.30 0.00e+00 790.00
IUUC-Sha-106905 Sarcophilus harrisii 96.42 0.00e+00 1749.00
IUUC-Sja-107838 Schizosaccharomyces japonicus 47.59 0.00e+00 835.00
IUUC-Spo-108299 Schizosaccharomyces pombe 47.53 0.00e+00 837.00
IUUC-Smo-108695 Selaginella moellendorffii 61.48 0.00e+00 1071.00
IUUC-Sit-110692 Setaria italica 62.83 0.00e+00 1101.00
IUUC-Sly-111775 Solanum lycopersicum 62.25 0.00e+00 1093.00
IUUC-Stu-112906 Solanum tuberosum 62.10 0.00e+00 988.00
IUUC-Sar-113472 Sorex araneus 91.10 0.00e+00 1160.00
IUUC-Sbi-114052 Sorghum bicolor 63.04 0.00e+00 1114.00
IUUC-Sre-115040 Sporisorium reilianum 52.62 0.00e+00 918.00
IUUC-Ssc-115593 Sus scrofa 98.68 0.00e+00 1832.00
IUUC-Tgu-117239 Taeniopygia guttata 94.04 0.00e+00 1722.00
IUUC-Tru-118025 Takifugu rubripes 92.46 0.00e+00 1659.00
IUUC-Tsy-118824 Tarsius syrichta 90.45 0.00e+00 1169.00
IUUC-Tni-120142 Tetraodon nigroviridis 90.33 0.00e+00 1653.00
IUUC-Tca-121613 Theobroma cacao 59.03 0.00e+00 1113.00
IUUC-Tre-122072 Trichoderma reesei 55.12 0.00e+00 936.00
IUUC-Tvi-122546 Trichoderma virens 54.62 0.00e+00 921.00
IUUC-Tae-125292 Triticum aestivum 61.38 0.00e+00 1100.00
IUUC-Tur-126283 Triticum urartu 54.01 0.00e+00 942.00
IUUC-Tme-127041 Tuber melanosporum 56.54 0.00e+00 975.00
IUUC-Tbe-127770 Tupaia belangeri 92.02 0.00e+00 1269.00
IUUC-Ttr-129294 Tursiops truncatus 98.68 0.00e+00 1830.00
IUUC-Uma-129351 Ustilago maydis 51.16 0.00e+00 908.00
IUUC-Vda-129716 Verticillium dahliae 55.61 0.00e+00 958.00
IUUC-Vpa-130037 Vicugna pacos 89.34 0.00e+00 941.00
IUUC-Vvi-131689 Vitis vinifera 59.91 0.00e+00 1112.00
IUUC-Xtr-132633 Xenopus tropicalis 93.86 0.00e+00 1679.00
IUUC-Xma-133347 Xiphophorus maculatus 87.77 0.00e+00 1677.00
IUUC-Yli-134455 Yarrowia lipolytica 50.38 0.00e+00 837.00
IUUC-Zma-135706 Zea mays 61.66 0.00e+00 1120.00
Created Date 25-Jun-2017

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