iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000196358.10	ENST00000393229.3	ENSP00000376921.3
ENSG00000196358.10	ENST00000372179.7	ENSP00000361252.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	35.90	2.20e-01	31.60	IUUC-Sce-106452

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Protein Sequence
(Fasta)

MLHLLALFLH CLPLASGDYD ICKSWVTTDE GPTWEFYACQ PKVMRLKDYV KVKVEPSGIT 60
CGDPPERFCS HENPYLCSNE CDASNPDLAH PPRLMFDKEE EGLATYWQSI TWSRYPSPLE 120

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Nucleotide Sequence
(Fasta)

CGCAGCCCGG ATCAGACCGA GAGATAAAAG CCCCGATGGT GATCGTGAGT GATGGCAAGA 60
GGATTTAGCC TCGGCATTAA CTTGGAGCGG AGTGCAGGGG GGCAGTGAAG CGCCCGCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0424--Laminin EGF-like domain
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal

Interpro

IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR008979--Galactose-bd-like
IPR002049--Laminin_EGF
IPR008211--Laminin_N

PROSITE

PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01248--EGF_LAM_1
PS50027--EGF_LAM_2
PS51117--LAMININ_NTER

Pfam

PF00053--Laminin_EGF
PF00055--Laminin_N

SMART

SM00181--EGF
SM00180--EGF_Lam
SM00136--LamNT

Gene Ontology

GO:0046658--C:anchored component of plasma membrane
GO:0030424--C:axon
GO:0005576--C:extracellular region
GO:0005886--C:plasma membrane
GO:0007409--P:axonogenesis
GO:0006501--P:C-terminal protein lipidation

KEGG

hsa:84628

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Sce-106452	Saccharomyces cerevisiae	35.00	1.50e-01	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence