Protein Structure - PDB UniProt ID PDB ID Strain Moleculel Fragment Q00987 3lbk A E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN Q00987 4zyf A E3 UBIQUITIN-PROTEIN LIGASE MDM2 N-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP RESIDUES 17-111 Q00987 4oba A, B, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-111 Q00987 5law A E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 2hdp A, B UBIQUITIN-PROTEIN LIGASE E3 MDM2 RING FINGER DOMAIN Q00987 4zfi A, B, C, D E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-113 Q00987 4mdn A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-110 Q00987 5lay A, B, C, D, E, F E3 UBIQUITIN-PROTEIN LIGASE MDM2 TRUNCATED N-TERMINAL DOMAIN Q00987 4qoc A, C, E, G, I, K E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4ere A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-111 Q00987 2ruh A E3 UBIQUITIN-PROTEIN LIGASE MDM2 MIP-MDM2 FUSION, UNP RESIDUES 6-120 Q00987 4hbm A, B, C, D, E, F, G, H E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4ogn A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 6-110 Q00987 2gv2 A UBIQUITIN-PROTEIN LIGASE E3 MDM2 P53 BINDING DOMAIN (RESIDUES: 17-125) Q00987 4zyc A, B, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 N-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP RESIDUES 17-111 Q00987 4jv9 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-111 Q00987 3lbl A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN Q00987 2m86 B E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-125 Q00987 3jzk A E3 UBIQUITIN-PROTEIN LIGASE MDM2 MDM2 N-TERMINAL DOMAIN, RESIDUES 17-111 Q00987 1t4f M OPTIMIZED P53 PEPTIDE Q00987 3eqs A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109 Q00987 4xxb B E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 293-334 Q00987 4erf A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-111 Q00987 4ue1 A, B, C, D E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN, RESIDUES 17-125 Q00987 3iwy A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109, SWIB DOMAIN Q00987 2vjf A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 RESIDUES 383-446 Q00987 3lnj A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109, P53 BINDING DOMAIN Q00987 4mdq A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-110 Q00987 4wt2 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 12-116 Q00987 5lav A E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 2fop B MDM2 PEPTIDE Q00987 4ogt A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUE 6-110 Q00987 3vzv A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 SWIB DOMAIN, UNP RESIDUES 25-109 Q00987 3jzs A PDIQ PEPTIDE (12MER) Q00987 2vje A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 RESIDUES 383-446 Q00987 4jwr A, B, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-111 Q00987 2axi A UBIQUITIN-PROTEIN LIGASE E3 MDM2 HDM2 Q00987 2c6a A UBIQUITIN-PROTEIN LIGASE E3 MDM2 Q00987 3v3b A, B SAH-P53-8 STAPLED-PEPTIDE Q00987 4qo4 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4hg7 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN (RESIDUES 17-125) Q00987 3jzr A PDI6W PEPTIDE (12MER) Q00987 4occ A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4oas A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 17-111 Q00987 4jv7 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-111 Q00987 4ogv A, B, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 7-111 Q00987 2mps A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 3-109 Q00987 1t4e A, B UBIQUITIN-PROTEIN LIGASE E3 MDM2 P53-BINDING DOMAIN Q00987 2lzg A E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4jvr A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-111 Q00987 4zyi A E3 UBIQUITIN-PROTEIN LIGASE MDM2 N-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP RESIDUES 17-111 Q00987 3g03 A, C HIGH AFFINITY SYNTHETIC PEPTIDE Q00987 5hmk A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 1ycr A MDM2 RESIDUES 17 - 125 Q00987 5laz A E3 UBIQUITIN-PROTEIN LIGASE MDM2 Q00987 4zgk A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-114 Q00987 4ud7 A, B, C, D MDM2 P53 BINDING DOMAIN, UNP RESIDUES 17-125 Q00987 3tpx A, C, E E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN (UNP RESIDUES 25-109) Q00987 4jve A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 18-111 Q00987 3vbg A, B, C, D E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109 Q00987 3iux A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109, P53 BINDING DOMAIN, SWIB DOMAIN Q00987 4ode A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 6-110 Q00987 3tj2 A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN (UNP RESIDUES 18-111) Q00987 1z1m A UBIQUITIN-PROTEIN LIGASE E3 MDM2 N-TERMINAL DOMAIN Q00987 4oq3 A, B, C, D E3 UBIQUITIN-PROTEIN LIGASE MDM2 N-TERMINAL DOMAIN, UNP RESIDUES 17-111 Q00987 4odf A E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 6-110 Q00987 2c6b A UBIQUITIN-PROTEIN LIGASE E3 MDM2 Q00987 4dij A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 N-TERMINAL DOMAIN, P53-BINDING DOMAIN, UNP RESIDUES 17-111 Q00987 4umn A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN, RESIDUES 6-125 Q00987 3lnz A, C, E, G, I, K, M, O E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109, P53 BINDING DOMAIN Q00987 4hfz A, C E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN (RESIDUES 17-125) Q00987 1rv1 A, B, C UBIQUITIN-PROTEIN LIGASE E3 MDM2 RESIDUES 25-109 Q00987 3w69 A, B E3 UBIQUITIN-PROTEIN LIGASE MDM2 UNP RESIDUES 25-109 Q00987 3tu1 A E3 UBIQUITIN-PROTEIN LIGASE MDM2 P53 BINDING DOMAIN (UNP RESIDUES 18-105) Q00987 3mqs D HDM2 PEPTIDE

Protein Structure - MMDB UniProt ID PDB code Chain ID MMDB ID Resolution Method Acceptable Q00987 4XXB A 131682 2.40 X-ray Acceptable Q00987 4MDN A 115137 1.91 X-ray Acceptable Q00987 3LNZ A 80705 1.95 X-ray Acceptable Q00987 1RV1 A 26209 2.30 X-ray Acceptable Q00987 1RV1 B 26209 2.30 X-ray Acceptable Q00987 1RV1 C 26209 2.30 X-ray Acceptable Q00987 1T4E A 31804 2.60 X-ray Acceptable Q00987 1T4E B 31804 2.60 X-ray Acceptable Q00987 3VBG B 100845 2.80 X-ray Acceptable Q00987 3VBG D 100845 2.80 X-ray Acceptable Q00987 1Z1M A 33784 0.00 NMR Acceptable Q00987 4QOC K 129046 1.70 X-ray Acceptable Q00987 3EQS A 70242 1.65 X-ray Acceptable Q00987 3TPX A 100662 1.80 X-ray Acceptable Q00987 3TPX E 100662 1.80 X-ray Acceptable Q00987 3LNZ G 80705 1.95 X-ray Acceptable Q00987 3VBG A 100845 2.80 X-ray Acceptable Q00987 3VBG C 100845 2.80 X-ray Acceptable Q00987 4WT2 A 125314 1.42 X-ray Acceptable Q00987 3W69 A 110623 1.90 X-ray Acceptable Q00987 3W69 B 110623 1.90 X-ray Acceptable Q00987 3VZV A 107257 2.80 X-ray Acceptable Q00987 3VZV B 107257 2.80 X-ray Acceptable Q00987 3IUX A 77694 1.65 X-ray Acceptable Q00987 3TPX C 100662 1.80 X-ray Acceptable Q00987 3IWY C 81543 1.93 X-ray Acceptable Q00987 3LNZ I 80705 1.95 X-ray Acceptable Q00987 3LNZ K 80705 1.95 X-ray Acceptable Q00987 3LNZ M 80705 1.95 X-ray Acceptable Q00987 3LNZ O 80705 1.95 X-ray Acceptable Q00987 3LNJ A 80704 2.40 X-ray Acceptable Q00987 3LNJ C 80704 2.40 X-ray Acceptable Q00987 3LNJ E 80704 2.40 X-ray Acceptable Q00987 4QOC I 129046 1.70 X-ray Acceptable Q00987 4ZYF A 131322 1.80 X-ray Acceptable Q00987 4DIJ A 99242 1.90 X-ray Acceptable Q00987 4DIJ B 99242 1.90 X-ray Acceptable Q00987 4OQ3 A 119932 2.30 X-ray Acceptable Q00987 4OQ3 C 119932 2.30 X-ray Acceptable Q00987 3LBL A 80835 1.60 X-ray Acceptable Q00987 3JZS A 78048 1.78 X-ray Acceptable Q00987 3IUX C 77694 1.65 X-ray Acceptable Q00987 3IWY A 81543 1.93 X-ray Acceptable Q00987 3LNZ C 80705 1.95 X-ray Acceptable Q00987 3LNZ E 80705 1.95 X-ray Acceptable Q00987 4ODE A 118872 1.80 X-ray Acceptable Q00987 4JVE A 109726 2.30 X-ray Acceptable Q00987 4MDQ A 115138 2.12 X-ray Acceptable Q00987 4QOC E 129046 1.70 X-ray Acceptable Q00987 4QOC G 129046 1.70 X-ray Acceptable Q00987 4OCC A 118871 1.80 X-ray Acceptable Q00987 4QOC C 129046 1.70 X-ray Acceptable Q00987 4ERF A 99960 2.00 X-ray Acceptable Q00987 4OQ3 B 119932 2.30 X-ray Acceptable Q00987 3TJ2 C 102801 2.10 X-ray Acceptable Q00987 4HG7 A 112224 1.60 X-ray Acceptable Q00987 4OAS A 117731 1.70 X-ray Acceptable Q00987 3JZK A 78214 2.10 X-ray Acceptable Q00987 4QOC A 129046 1.70 X-ray Acceptable Q00987 4ZYI A 131323 1.67 X-ray Acceptable Q00987 4OQ3 D 119932 2.30 X-ray Acceptable Q00987 4OGN A 118874 1.38 X-ray Acceptable Q00987 4OCC E 118871 1.80 X-ray Acceptable Q00987 4ERF C 99960 2.00 X-ray Acceptable Q00987 4ERF E 99960 2.00 X-ray Acceptable Q00987 4OCC C 118871 1.80 X-ray Acceptable Q00987 4QO4 A 121592 1.70 X-ray Acceptable Q00987 3TJ2 A 102801 2.10 X-ray Acceptable Q00987 4OGT A 118875 1.54 X-ray Acceptable Q00987 4OAS E 117731 1.70 X-ray Acceptable Q00987 4ERE B 99959 1.80 X-ray Acceptable Q00987 4JVR C 109727 1.70 X-ray Acceptable Q00987 4OAS C 117731 1.70 X-ray Acceptable Q00987 4JWR A 109729 2.35 X-ray Acceptable Q00987 4JWR B 109729 2.35 X-ray Acceptable Q00987 4JWR C 109729 2.35 X-ray Acceptable Q00987 4ODF A 118873 2.20 X-ray Acceptable Q00987 4OBA A 118481 1.60 X-ray Acceptable Q00987 4OBA B 118481 1.60 X-ray Acceptable Q00987 4OBA C 118481 1.60 X-ray Acceptable Q00987 4ZYC B 131151 1.95 X-ray Acceptable Q00987 3V3B B 96570 2.00 X-ray Acceptable Q00987 4JVR E 109727 1.70 X-ray Acceptable Q00987 4ZYC C 131151 1.95 X-ray Acceptable Q00987 4JV7 A 109724 2.20 X-ray Acceptable Q00987 4JV9 A 109725 2.50 X-ray Acceptable Q00987 3LBL C 80835 1.60 X-ray Acceptable Q00987 4OGV A 118876 2.20 X-ray Acceptable Q00987 4OGV B 118876 2.20 X-ray Acceptable Q00987 4OGV C 118876 2.20 X-ray Acceptable Q00987 3JZR A 78047 2.10 X-ray Acceptable Q00987 4ERE A 99959 1.80 X-ray Acceptable Q00987 4HBM A 104160 1.90 X-ray Acceptable Q00987 4ZYC A 131151 1.95 X-ray Acceptable Q00987 4JVR A 109727 1.70 X-ray Acceptable Q00987 3V3B A 96570 2.00 X-ray Acceptable Q00987 3LBK A 80834 2.30 X-ray Acceptable Q00987 4HBM C 104160 1.90 X-ray Acceptable Q00987 4HFZ C 112221 2.69 X-ray Acceptable Q00987 4HBM E 104160 1.90 X-ray Acceptable Q00987 3LBL E 80835 1.60 X-ray Acceptable Q00987 4HBM B 104160 1.90 X-ray Acceptable Q00987 4HBM H 104160 1.90 X-ray Acceptable Q00987 4HBM F 104160 1.90 X-ray Acceptable Q00987 4HBM D 104160 1.90 X-ray Acceptable Q00987 4HBM G 104160 1.90 X-ray Acceptable Q00987 3TU1 A 94828 1.60 X-ray Acceptable Q00987 2AXI A 38008 1.40 X-ray Acceptable Q00987 2GV2 A 74659 1.80 X-ray Acceptable Q00987 1T4F M 31805 1.90 X-ray Acceptable Q00987 4UMN A 120391 1.99 X-ray Acceptable Q00987 1YCR A 52118 2.60 X-ray Acceptable Q00987 4UMN B 120391 1.99 X-ray Acceptable Q00987 4HFZ A 112221 2.69 X-ray Acceptable Q00987 3G03 A 70844 1.80 X-ray Acceptable Q00987 3G03 C 70844 1.80 X-ray Acceptable Q00987 2C6A A 37206 0.00 NMR Acceptable Q00987 2C6B A 37207 0.00 NMR Acceptable Q00987 4XXB B 131682 2.40 X-ray Acceptable Q00987 2FOP A 37788 2.10 X-ray Acceptable Q00987 3MQS C 84390 2.40 X-ray Acceptable Q00987 2VJF A 64405 2.30 X-ray Acceptable Q00987 2VJF C 64405 2.30 X-ray Acceptable Q00987 2VJF B 64405 2.30 X-ray Acceptable Q00987 2VJF D 64405 2.30 X-ray Acceptable Q00987 2HDP A 42837 0.00 NMR Acceptable Q00987 2HDP B 42837 0.00 NMR Acceptable Q00987 2VJE D 64404 2.20 X-ray Acceptable Q00987 2VJE B 64404 2.20 X-ray Acceptable Q00987 2VJE A 64404 2.20 X-ray Acceptable Q00987 2VJE C 64404 2.20 X-ray Acceptable Q00987 4UE1 A 135313 1.45 X-ray Acceptable Q00987 4UE1 B 135313 1.45 X-ray Acceptable Q00987 4UD7 A 135311 1.60 X-ray Acceptable Q00987 4UE1 C 135313 1.45 X-ray Acceptable Q00987 4UE1 D 135313 1.45 X-ray Acceptable Q00987 4UD7 B 135311 1.60 X-ray Acceptable Q00987 4UD7 C 135311 1.60 X-ray Acceptable Q00987 4UD7 D 135311 1.60 X-ray Acceptable Q00987 5HMK B 138186 2.17 X-ray Acceptable Q00987 5HMK A 138186 2.17 X-ray Acceptable