MDM2
Drug & target - TTD
NameType of TargetSynonymsDiseaseDrugsInhibitorAntibody
Ubiquitin-protein ligase E3 Mdm2Clinical trial targetMDM2;MDM2 protein;Oncoprotein Mdm2;P53-binding protein Mdm2;Double minute 2 protein;Hdm2Cancer;Osteosarcoma;Ovarian cancer;Lymphoma;Breast cancerAMG 232;AMG 232;SAR-405838;DS-3032;RG7388;RG7388;RG7388;JNJ-26854165;JNJ-26854165;JNJ-26854165;JNJ-26854165;SAR405838;RG7775;R7112;CGM097SAR-405838;DS-3032;RG7775;R7112;CGM097
mRNA of Human mdm2Research targetE3 ubiquitinprotein ligase Mdm2 (mRNA);Double minute 2 protein (mRNA);Hdm2 (mRNA);Oncoprotein Mdm2 (mRNA);p53binding protein Mdm2 (mRNA);MDM2 (mRNA)Under research;CancerPLSQETFSDLWKLLPEN-NH2;NU-8231;NSC-66811;NUTLIN-3
Drug & target - CARLSBAD
ID Name UniProt Species Type Activity
943 E3 ubiquitin-protein ligase Mdm2 Q00987 human protein 333 Activities; 232 Active Scaffolds; 43 Active MCESs
Drug & target - PDTD
Ensembl_gene_ID UniProt ID PDB Code
ENSG00000135679.22 Q00987 1RV1
Drug & target - Manually collected
Targeting AgentTargetStageReference PMID
Nutlins; RG7112; RO5503781; RO5045337MDM2phase I14704432; 25396320; 26459177
RG7388MDM2phase I25396320; 25844600
JNJ-26854165MDM2phase I21922647; 26919436
MI-77301; SAR405838MDM2phase I25145672; 25396320
AMG 232MDM2phase I24456472; 25145672
MK-8242; SCH 900242MDM2phase I18316739; 22407829; 28240971
CGM097; RG7112MDM2phase I23084521; 26181851
MI-63MDM2pre-clinical19707204
MEL23; MEL24MDM2pre-clinical22586610
HLI98MDM2pre-clinical15950904
TDP521252; TDP665759MDM2pre-clinical16432175