iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000042870.15	ENSMUST00000165630.2	ENSMUSP00000130854.1
ENSMUSG00000042870.15	ENSMUST00000212564.1	ENSMUSP00000148584.1
ENSMUSG00000042870.15	ENSMUST00000212299.1	ENSMUSP00000148670.1
ENSMUSG00000042870.15	ENSMUST00000078847.12	ENSMUSP00000077891.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/GAT	GAT	14563850
UBD/Alpha-Helix/VHS	VHS	14563850

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/VHS	2.70e-51	174.1	20	152
UBD/Alpha-Helix/GAT	3.10e-28	99.5	214	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkri.nnknphvalraLtlLdscvsnCgkkfhvevaskdllee..lrell.kne 85
           at+ +++sedw+l++eicd+i+et+eg+kda+ra++kri +nkn+h++++aLt+L++cv+nCg++fhv+va++d++e+  +r++l kn+
   Q: 20   ATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRImGNKNFHEVMLALTVLETCVKNCGHRFHVLVANQDFVENvlVRTILpKNN 108
           68999**********************************9**************************************999******** PP
   S: 86   nepkvieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           +++ v++K+++li+sWad+++++p+l+++va++++l+++Glefp
   Q: 109  PPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVYEDLRRKGLEFP 152
           *******************************************8 PP

UBD/Alpha-Helix/GAT

   S: 38   aekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykql 126
            e+i+kl+sele+v++nv++++eml+el+p++ ep+d ellqel++tc+a+++++l+li +  +n++l++ell++nD+ln+v+++++++
   Q: 214  PEQIGKLRSELEMVSGNVRVMSEMLTELVPTQVEPADLELLQELNRTCRAMQQRILELIPR-ISNEQLTEELLMINDNLNNVFLRHERF 301
           589**********************************************************.*************************99 PP
   S: 127  k 127
           +
   Q: 302  E 302
           7 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with ZFYVE16; interaction is required to target it to endosomes.

Protein Sequence
(Fasta)

MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA FRAVKKRIMG 60
NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV RTILPKNNPP TIVHDKVLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCGGGTC GGCGGCGCCG GCGGTTGCTG TCACCTGATT CTGGGAGCTG GTGGCAGCGG 60
TAGCCGCGGC AATGGACTTT CTCCTGGGAA ATCCGTTCAG CTCTCCGGTG GGACAACGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR002014--VHS_dom

PROSITE

PS50909--GAT
PS50179--VHS

Pfam

PF03127--GAT
PF00790--VHS

SMART

SM00288--VHS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0030276--F:clathrin binding
GO:0006886--P:intracellular protein transport

KEGG

mmu:21968

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001372	Ailuropoda melanoleuca	86.63	0.00e+00	862.00
IUUC-Apl-004197	Anas platyrhynchos	71.63	0.00e+00	664.00
IUUC-Aca-005277	Anolis carolinensis	71.31	0.00e+00	647.00
IUUC-Bta-013410	Bos taurus	89.23	0.00e+00	872.00
IUUC-Cel-018158	Caenorhabditis elegans	49.28	4.00e-89	322.00
IUUC-Cja-018944	Callithrix jacchus	83.77	0.00e+00	814.00
IUUC-Cfa-021024	Canis familiaris	87.80	0.00e+00	852.00
IUUC-Cpo-021418	Cavia porcellus	83.16	0.00e+00	803.00
IUUC-Csa-023653	Chlorocebus sabaeus	86.47	0.00e+00	862.00
IUUC-Cne-026931	Cryptococcus neoformans	26.97	1.00e-14	74.70
IUUC-Dno-029610	Dasypus novemcinctus	87.78	0.00e+00	701.00
IUUC-Dor-030925	Dipodomys ordii	78.66	0.00e+00	750.00
IUUC-Eca-034207	Equus caballus	90.24	0.00e+00	867.00
IUUC-Eeu-035025	Erinaceus europaeus	73.33	2.00e-122	432.00
IUUC-Fca-036407	Felis catus	87.58	0.00e+00	807.00
IUUC-Fal-036809	Ficedula albicollis	72.76	0.00e+00	677.00
IUUC-Gga-040357	Gallus gallus	72.69	0.00e+00	719.00
IUUC-Ggo-044454	Gorilla gorilla	88.20	0.00e+00	871.00
IUUC-Hsa-046652	Homo sapiens	89.43	0.00e+00	876.00
IUUC-Itr-049028	Ictidomys tridecemlineatus	84.50	0.00e+00	856.00
IUUC-Laf-054231	Loxodonta africana	86.74	0.00e+00	669.00
IUUC-Mcc-055475	Macaca mulatta	89.84	0.00e+00	876.00
IUUC-Meu-056002	Macropus eugenii	64.95	4.00e-152	530.00
IUUC-Mla-058817	Melampsora laricipopulina	24.85	4.00e-19	89.40
IUUC-Mga-059199	Meleagris gallopavo	70.11	0.00e+00	655.00
IUUC-Mmr-061193	Microcebus murinus	89.66	0.00e+00	817.00
IUUC-Mdo-062456	Monodelphis domestica	78.38	0.00e+00	701.00
IUUC-Mpu-066772	Mustela putorius furo	88.03	0.00e+00	885.00
IUUC-Mlu-067475	Myotis lucifugus	84.02	0.00e+00	684.00
IUUC-Nle-068998	Nomascus leucogenys	86.23	0.00e+00	843.00
IUUC-Oan-073103	Ornithorhynchus anatinus	73.19	0.00e+00	723.00
IUUC-Ocu-073922	Oryctolagus cuniculus	82.78	0.00e+00	767.00
IUUC-Oga-089050	Otolemur garnettii	80.12	0.00e+00	773.00
IUUC-Oar-090246	Ovis aries	84.91	0.00e+00	816.00
IUUC-Ptr-090714	Pan troglodytes	88.84	0.00e+00	867.00
IUUC-Pan-092875	Papio anubis	89.84	0.00e+00	876.00
IUUC-Psi-094051	Pelodiscus sinensis	71.62	0.00e+00	694.00
IUUC-Pab-098291	Pongo abelii	88.24	0.00e+00	801.00
IUUC-Pca-100907	Procavia capensis	80.69	0.00e+00	738.00
IUUC-Pva-102610	Pteropus vampyrus	80.49	0.00e+00	778.00
IUUC-Pgr-103677	Puccinia graminis	24.82	4.00e-20	92.80
IUUC-Rno-105809	Rattus norvegicus	96.14	0.00e+00	942.00
IUUC-Sce-106195	Saccharomyces cerevisiae	25.85	3.00e-17	83.60
IUUC-Sha-107255	Sarcophilus harrisii	80.04	0.00e+00	691.00
IUUC-Ssl-108413	Sclerotinia sclerotiorum	39.04	7.00e-22	96.30
IUUC-Sre-115232	Sporisorium reilianum	25.23	1.00e-17	84.70
IUUC-Tgu-117517	Taeniopygia guttata	73.85	0.00e+00	716.00
IUUC-Tni-120701	Tetraodon nigroviridis	51.31	2.00e-144	505.00
IUUC-Ttr-128710	Tursiops truncatus	81.54	0.00e+00	746.00
IUUC-Uma-129380	Ustilago maydis	25.73	2.00e-14	74.30
IUUC-Vpa-130381	Vicugna pacos	69.10	1.00e-104	373.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence