iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135679.22	ENST00000258149.9	ENSP00000258149.6
ENSG00000135679.22	ENST00000311420.13	ENSP00000310742.9
ENSG00000135679.22	ENST00000393417.7	ENSP00000429021.2
ENSG00000135679.22	ENST00000258148.11	ENSP00000258148.7
ENSG00000135679.22	ENST00000393415.7	ENSP00000377067.3
ENSG00000135679.22	ENST00000543323.5	ENSP00000439238.1
ENSG00000135679.22	ENST00000393416.6	ENSP00000377068.2
ENSG00000135679.22	ENST00000544561.5	ENSP00000441841.1
ENSG00000135679.22	ENST00000393410.5	ENSP00000377062.1
ENSG00000135679.22	ENST00000496959.5	ENSP00000429692.1
ENSG00000135679.22	ENST00000299252.8	ENSP00000299252.4
ENSG00000135679.22	ENST00000481186.5	ENSP00000431110.1
ENSG00000135679.22	ENST00000360430.6	ENSP00000353611.2
ENSG00000135679.22	ENST00000517852.5	ENSP00000430257.1
ENSG00000135679.22	ENST00000545204.1	ENSP00000444597.1
ENSG00000135679.22	ENST00000540352.5	ENSP00000445030.1
ENSG00000135679.22	ENST00000542502.5	ENSP00000444566.1
ENSG00000135679.22	ENST00000393413.7	ENSP00000377065.3
ENSG00000135679.22	ENST00000350057.9	ENSP00000266624.9
ENSG00000135679.22	ENST00000348801.6	ENSP00000335096.3
ENSG00000135679.22	ENST00000478070.1	ENSP00000430906.1
ENSG00000135679.22	ENST00000428863.6	ENSP00000410694.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Drug and target
TTD	CARLSBAD	PDTD	Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17545634; 16866370; 18802403; 18981217; 19032150; 14642282; 19713960; 19703557; 19128510; 19683495; 18451149; 18665269; 18948082; 19372219; 19369353; 19363159; 18784257; 19448429; 19345326; 19176998; 19321440; 19247369; 19219073; 17377491; 11927554; 15975924; 15242646; 15456867; 14769800; 20592017; 16678796; 16170383; 17301054; 15577944; 21460856; 21093410; 20453884; 12145204; 15640443; 23246967

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.01	18.0	444	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv.lpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC+ ++k+g +v +  gH++ +++C +k+      ++++  CP+Cr
   Q: 444  CVICQGRPKNGCIVhGKTGHLMaCFTCAKKL------KKRNKPCPVCR 485
           ********998554266***888*****999......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity).

Protein Sequence
(Fasta)

MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVL 60
FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY RNLVVVNQQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGCGCA CCGAGGCACC GCGGCGAGCT TGGCTGCTTC TGGGGCCTGT GTGGCCCTGT 60
GTGTCGGAAA GATGGAGCAA GAAGCCGAGC CCGAGGGGCG GCCGCGACCC CTCTGACCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030666--C:endocytic vesicle membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0045202--C:synapse
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0016874--F:ligase activity
GO:0002039--F:p53 binding
GO:0019789--F:SUMO transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071312--P:cellular response to alkaloid
GO:0071236--P:cellular response to antibiotic
GO:0071391--P:cellular response to estrogen stimulus
GO:0071363--P:cellular response to growth factor stimulus
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071456--P:cellular response to hypoxia
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0071494--P:cellular response to UV-C
GO:0071301--P:cellular response to vitamin B1
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010977--P:negative regulation of neuron projection development
GO:0010955--P:negative regulation of protein processing
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018205--P:peptidyl-lysine modification
GO:0008284--P:positive regulation of cell proliferation
GO:0010628--P:positive regulation of gene expression
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046827--P:positive regulation of protein export from nucleus
GO:1904754--P:positive regulation of vascular associated smooth muscle cell migration
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0016579--P:protein deubiquitination
GO:0034504--P:protein localization to nucleus
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0042176--P:regulation of protein catabolic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0046677--P:response to antibiotic
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0045472--P:response to ether
GO:1904404--P:response to formaldehyde
GO:0010039--P:response to iron ion
GO:0032026--P:response to magnesium ion
GO:0043278--P:response to morphine
GO:0048545--P:response to steroid hormone
GO:0009636--P:response to toxic substance
GO:1990785--P:response to water-immersion restraint stress
GO:0036369--P:transcription factor catabolic process
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development
GO:0016032--P:viral process

KEGG

hsa:4193

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	94.93	0.00e+00	827.00
IUUC-Apl-003193	Anas platyrhynchos	65.59	3.00e-159	555.00
IUUC-Aca-004305	Anolis carolinensis	59.57	1.00e-118	420.00
IUUC-Ame-010675	Astyanax mexicanus	45.33	4.00e-84	305.00
IUUC-Bta-013270	Bos taurus	93.90	0.00e+00	792.00
IUUC-Cja-019744	Callithrix jacchus	95.94	0.00e+00	819.00
IUUC-Cfa-020807	Canis familiaris	92.65	0.00e+00	757.00
IUUC-Cpo-022182	Cavia porcellus	89.63	0.00e+00	750.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	8.00e-06	41.60
IUUC-Csa-023541	Chlorocebus sabaeus	99.19	0.00e+00	856.00
IUUC-Cho-024831	Choloepus hoffmanni	74.64	3.00e-90	324.00
IUUC-Csv-026151	Ciona savignyi	31.17	4.00e-11	61.60
IUUC-Dre-028419	Danio rerio	43.54	7.00e-51	194.00
IUUC-Dno-028950	Dasypus novemcinctus	92.89	0.00e+00	817.00
IUUC-Dor-031048	Dipodomys ordii	72.18	1.00e-172	599.00
IUUC-Ete-032264	Echinops telfairi	68.97	2.00e-172	598.00
IUUC-Eca-033301	Equus caballus	83.77	0.00e+00	730.00
IUUC-Eeu-035005	Erinaceus europaeus	80.86	0.00e+00	644.00
IUUC-Fca-035454	Felis catus	94.70	0.00e+00	815.00
IUUC-Fal-036720	Ficedula albicollis	62.13	7.00e-75	273.00
IUUC-Gmo-039296	Gadus morhua	41.42	5.00e-45	174.00
IUUC-Gga-040251	Gallus gallus	66.73	3.00e-153	535.00
IUUC-Ggo-044948	Gorilla gorilla	90.43	0.00e+00	772.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	92.51	0.00e+00	764.00
IUUC-Lch-050037	Latimeria chalumnae	57.64	6.00e-116	410.00
IUUC-Loc-051837	Lepisosteus oculatus	50.91	2.00e-112	399.00
IUUC-Laf-053483	Loxodonta africana	85.57	0.00e+00	737.00
IUUC-Mcc-055294	Macaca mulatta	99.40	0.00e+00	872.00
IUUC-Mga-060007	Meleagris gallopavo	65.56	4.00e-145	508.00
IUUC-Mmr-060673	Microcebus murinus	94.50	0.00e+00	823.00
IUUC-Mdo-063057	Monodelphis domestica	74.59	0.00e+00	665.00
IUUC-Mmu-063207	Mus musculus	80.24	0.00e+00	640.00
IUUC-Mpu-065836	Mustela putorius furo	93.28	0.00e+00	819.00
IUUC-Mlu-068193	Myotis lucifugus	89.29	0.00e+00	784.00
IUUC-Nle-069927	Nomascus leucogenys	99.20	0.00e+00	871.00
IUUC-Opr-070590	Ochotona princeps	85.45	0.00e+00	709.00
IUUC-Ont-071984	Oreochromis niloticus	40.16	4.00e-73	268.00
IUUC-Oan-072744	Ornithorhynchus anatinus	72.85	5.00e-163	567.00
IUUC-Ocu-074071	Oryctolagus cuniculus	93.54	0.00e+00	790.00
IUUC-Ola-087329	Oryzias latipes	41.70	4.00e-72	265.00
IUUC-Oga-088135	Otolemur garnettii	84.85	0.00e+00	742.00
IUUC-Oar-089726	Ovis aries	93.33	0.00e+00	824.00
IUUC-Ptr-091399	Pan troglodytes	99.60	0.00e+00	874.00
IUUC-Pan-092720	Papio anubis	99.40	0.00e+00	872.00
IUUC-Psi-093591	Pelodiscus sinensis	66.96	5.00e-132	464.00
IUUC-Pma-094500	Petromyzon marinus	62.50	9.00e-19	86.70
IUUC-Pfo-096316	Poecilia formosa	41.41	2.00e-72	266.00
IUUC-Pab-097696	Pongo abelii	98.79	0.00e+00	862.00
IUUC-Pca-100974	Procavia capensis	83.53	0.00e+00	768.00
IUUC-Pva-102488	Pteropus vampyrus	87.93	0.00e+00	726.00
IUUC-Rno-105641	Rattus norvegicus	83.06	0.00e+00	671.00
IUUC-Sha-107314	Sarcophilus harrisii	74.14	0.00e+00	686.00
IUUC-Sar-112938	Sorex araneus	85.92	0.00e+00	748.00
IUUC-Ssc-115495	Sus scrofa	93.48	0.00e+00	780.00
IUUC-Tgu-116623	Taeniopygia guttata	64.89	4.00e-151	528.00
IUUC-Tru-117820	Takifugu rubripes	40.23	4.00e-72	265.00
IUUC-Tsy-119162	Tarsius syrichta	68.21	1.00e-90	326.00
IUUC-Tbe-127816	Tupaia belangeri	76.39	5.00e-125	441.00
IUUC-Ttr-129194	Tursiops truncatus	82.96	0.00e+00	672.00
IUUC-Vpa-130326	Vicugna pacos	88.10	0.00e+00	736.00
IUUC-Xtr-132216	Xenopus tropicalis	56.63	8.00e-120	424.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence