iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000091831.21	ENST00000338799.9	ENSP00000342630.5
ENSG00000091831.21	ENST00000406599.5	ENSP00000384064.1
ENSG00000091831.21	ENST00000427531.6	ENSP00000394721.2
ENSG00000091831.21	ENST00000415488.1	ENSP00000401995.1
ENSG00000091831.21	ENST00000456483.3	ENSP00000415934.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	JASPAR	circBase
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC	PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UMI	UMI	23591816

Organism

Homo sapiens

Functional Description
(View)

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY 60
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF 120

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Nucleotide Sequence
(Fasta)

GAGCCTCAAA TATCTCCAAA ATCTGATACC AATCCTTTTG ATTGTGAATT ATATTCTGTA 60
GCTACCAAAG AAGGTAAGTT TTTATTTTTT CTACTCTATT AACTTTCCCT TGGACAACTG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0051117--F:ATPase binding
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0019899--F:enzyme binding
GO:0030284--F:estrogen receptor activity
GO:0034056--F:estrogen response element binding
GO:0042802--F:identical protein binding
GO:0030235--F:nitric-oxide synthase regulator activity
GO:0019901--F:protein kinase binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0006338--P:chromatin remodeling
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0030518--P:intracellular steroid hormone receptor signaling pathway
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0016579--P:protein deubiquitination
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0032355--P:response to estradiol
GO:0043627--P:response to estrogen
GO:0007165--P:signal transduction
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0060065--P:uterus development
GO:0060068--P:vagina development

KEGG

hsa:2099

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	93.10	0.00e+00	798.00
IUUC-Apl-003688	Anas platyrhynchos	79.93	0.00e+00	802.00
IUUC-Aca-005222	Anolis carolinensis	77.63	0.00e+00	870.00
IUUC-Ame-010731	Astyanax mexicanus	57.42	3.00e-137	482.00
IUUC-Bta-013112	Bos taurus	89.26	0.00e+00	937.00
IUUC-Cja-019408	Callithrix jacchus	96.97	0.00e+00	1056.00
IUUC-Cfa-020694	Canis familiaris	89.09	0.00e+00	953.00
IUUC-Cpo-021426	Cavia porcellus	85.91	0.00e+00	919.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.80e+00	26.60
IUUC-Csa-023736	Chlorocebus sabaeus	98.36	0.00e+00	924.00
IUUC-Dre-027698	Danio rerio	56.84	1.00e-134	473.00
IUUC-Dno-029477	Dasypus novemcinctus	90.45	0.00e+00	767.00
IUUC-Dor-030572	Dipodomys ordii	89.19	0.00e+00	739.00
IUUC-Ete-032849	Echinops telfairi	71.66	0.00e+00	661.00
IUUC-Eca-033605	Equus caballus	87.39	0.00e+00	959.00
IUUC-Eeu-034683	Erinaceus europaeus	89.25	3.00e-106	378.00
IUUC-Fca-035928	Felis catus	92.17	0.00e+00	788.00
IUUC-Fal-036754	Ficedula albicollis	77.35	0.00e+00	880.00
IUUC-Gmo-038872	Gadus morhua	57.51	4.00e-112	398.00
IUUC-Gga-040988	Gallus gallus	78.78	0.00e+00	870.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.46	5.00e-127	448.00
IUUC-Ggo-044749	Gorilla gorilla	98.99	0.00e+00	1076.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	90.79	0.00e+00	979.00
IUUC-Loc-052414	Lepisosteus oculatus	59.21	0.00e+00	627.00
IUUC-Mcc-054781	Macaca mulatta	98.82	0.00e+00	1073.00
IUUC-Meu-056232	Macropus eugenii	85.38	0.00e+00	915.00
IUUC-Mga-059319	Meleagris gallopavo	79.29	0.00e+00	875.00
IUUC-Mmr-061636	Microcebus murinus	92.12	9.00e-174	603.00
IUUC-Mdo-062661	Monodelphis domestica	86.55	0.00e+00	930.00
IUUC-Mmu-063330	Mus musculus	88.98	0.00e+00	939.00
IUUC-Mpu-065757	Mustela putorius furo	91.79	0.00e+00	971.00
IUUC-Mlu-067712	Myotis lucifugus	90.16	0.00e+00	853.00
IUUC-Nle-069283	Nomascus leucogenys	98.32	0.00e+00	1021.00
IUUC-Opr-070391	Ochotona princeps	88.42	0.00e+00	991.00
IUUC-Ont-071369	Oreochromis niloticus	56.77	1.00e-119	423.00
IUUC-Oan-073734	Ornithorhynchus anatinus	73.18	7.00e-130	456.00
IUUC-Ocu-074292	Oryctolagus cuniculus	90.65	0.00e+00	977.00
IUUC-Oba-075103	Oryza barthii	28.21	9.00e-03	35.40
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.70
IUUC-Olo-080944	Oryza longistaminata	28.21	4.00e-03	34.70
IUUC-Oni-082560	Oryza nivara	28.21	7.00e-03	35.80
IUUC-Ola-087052	Oryzias latipes	51.31	3.00e-126	445.00
IUUC-Oga-088586	Otolemur garnettii	91.81	0.00e+00	994.00
IUUC-Oar-090156	Ovis aries	91.05	0.00e+00	814.00
IUUC-Ptr-091321	Pan troglodytes	99.16	0.00e+00	1076.00
IUUC-Pan-092851	Papio anubis	98.66	0.00e+00	1071.00
IUUC-Psi-093434	Pelodiscus sinensis	78.49	0.00e+00	913.00
IUUC-Pfo-097379	Poecilia formosa	56.75	4.00e-133	468.00
IUUC-Pab-097735	Pongo abelii	98.99	0.00e+00	1074.00
IUUC-Pva-102125	Pteropus vampyrus	88.57	0.00e+00	954.00
IUUC-Rno-106121	Rattus norvegicus	88.67	0.00e+00	936.00
IUUC-Sha-107547	Sarcophilus harrisii	86.55	0.00e+00	927.00
IUUC-Sar-113650	Sorex araneus	78.74	3.00e-177	614.00
IUUC-Tgu-117175	Taeniopygia guttata	78.27	0.00e+00	883.00
IUUC-Tru-117545	Takifugu rubripes	53.96	8.00e-135	474.00
IUUC-Tsy-119586	Tarsius syrichta	79.03	0.00e+00	850.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.64	8.00e-137	480.00
IUUC-Tbe-127548	Tupaia belangeri	81.08	0.00e+00	632.00
IUUC-Ttr-128374	Tursiops truncatus	86.72	0.00e+00	873.00
IUUC-Vpa-130464	Vicugna pacos	81.69	2.00e-154	538.00
IUUC-Xtr-132171	Xenopus tropicalis	69.41	0.00e+00	736.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence